| A novel genetic system to detect protein–protein interactions S Fields, O Song Nature 340 (6230), 245-246, 1989 | 9332 | 1989 |
| A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae P Uetz, L Giot, G Cagney, TA Mansfield, RS Judson, JR Knight, ... Nature 403 (6770), 623-627, 2000 | 6142 | 2000 |
| Comparative assessment of large-scale data sets of protein–protein interactions C Von Mering, R Krause, B Snel, M Cornell, SG Oliver, S Fields, P Bork Nature 417 (6887), 399-403, 2002 | 3003 | 2002 |
| The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest. CT Chien, PL Bartel, R Sternglanz, S Fields Proceedings of the National Academy of Sciences 88 (21), 9578-9582, 1991 | 2373 | 1991 |
| A network of protein–protein interactions in yeast B Schwikowski, P Uetz, S Fields Nature biotechnology 18 (12), 1257-1261, 2000 | 1766 | 2000 |
| Protein-protein interactions: methods for detection and analysis EM Phizicky, S Fields Microbiological reviews 59 (1), 94-123, 1995 | 1559 | 1995 |
| Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients M Kaeberlein, RW Powers III, KK Steffen, EA Westman, D Hu, N Dang, ... Science 310 (5751), 1193-1196, 2005 | 1537 | 2005 |
| Presence of a potent transcription activating sequence in the p53 protein S Fields, SK Jang Science 249 (4972), 1046-1049, 1990 | 1200 | 1990 |
| Extension of chronological life span in yeast by decreased TOR pathway signaling RW Powers, M Kaeberlein, SD Caldwell, BK Kennedy, S Fields Genes & development 20 (2), 174-184, 2006 | 1158 | 2006 |
| A three-dimensional model of the yeast genome Z Duan, M Andronescu, K Schutz, S McIlwain, YJ Kim, C Lee, J Shendure, ... Nature 465 (7296), 363-367, 2010 | 1106 | 2010 |
| The two-hybrid system: an assay for protein-protein interactions S Fields, R Sternglanz Trends in Genetics 10 (8), 286-292, 1994 | 1058 | 1994 |
| Deep mutational scanning: a new style of protein science DM Fowler, S Fields Nature methods 11 (8), 801-807, 2014 | 1055 | 2014 |
| Substrate-specific activation of sirtuins by resveratrol M Kaeberlein, T McDonagh, B Heltweg, J Hixon, EA Westman, ... Journal of Biological Chemistry 280 (17), 17038-17045, 2005 | 929 | 2005 |
| Protein analysis on a proteomic scale E Phizicky, PIH Bastiaens, H Zhu, M Snyder, S Fields Nature 422 (6928), 208-215, 2003 | 919 | 2003 |
| A combined experimental and computational strategy to define protein interaction networks for peptide recognition modules AHY Tong, B Drees, G Nardelli, GD Bader, B Brannetti, L Castagnoli, ... Science 295 (5553), 321-324, 2002 | 914 | 2002 |
| Elimination of false positives that arise in using the two-hybrid system. P Bartel, CT Chien, R Sternglanz, S Fields Biotechniques 14 (6), 920-924, 1993 | 786 | 1993 |
| A three-hybrid system to detect RNA-protein interactions in vivo. DJ SenGupta, B Zhang, B Kraemer, P Pochart, S Fields, M Wickens Proceedings of the national Academy of Sciences 93 (16), 8496-8501, 1996 | 732 | 1996 |
| Global mapping of protein-DNA interactions in vivo by digital genomic footprinting JR Hesselberth, X Chen, Z Zhang, PJ Sabo, R Sandstrom, AP Reynolds, ... Nature methods 6 (4), 283-289, 2009 | 722 | 2009 |
| Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation DL Swaney, P Beltrao, L Starita, A Guo, J Rush, S Fields, NJ Krogan, ... Nature methods 10 (7), 676-682, 2013 | 669 | 2013 |
| A conserved RNA-binding protein that regulates sexual fates in the C. elegans hermaphrodite germ line B Zhang, M Gallegos, A Puoti, E Durkin, S Fields, J Kimble, MP Wickens Nature 390 (6659), 477-484, 1997 | 647 | 1997 |
