Giuseppina De Simone
Giuseppina De Simone
Istituto di Biostrutture e Bioimmagini-CNR
Verified email at unina.it
TitleCited byYear
Multiple binding modes of inhibitors to carbonic anhydrases: how to design specific drugs targeting 15 different isoforms?
V Alterio, A Di Fiore, K D’Ambrosio, CT Supuran, G De Simone
Chemical reviews 112 (8), 4421-4468, 2012
6832012
Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX
V Alterio, M Hilvo, A Di Fiore, CT Supuran, P Pan, S Parkkila, A Scaloni, ...
Proceedings of the National Academy of Sciences 106 (38), 16233-16238, 2009
3672009
Histone deacetylase and Cullin3–RENKCTD11 ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation
G Canettieri, L Di Marcotullio, A Greco, S Coni, L Antonucci, P Infante, ...
Nature cell biology 12 (2), 132, 2010
2462010
Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes
M Hilvo, L Baranauskiene, AM Salzano, A Scaloni, D Matulis, A Innocenti, ...
Journal of Biological Chemistry 283 (41), 27799-27809, 2008
2432008
Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX
V Alterio, RM Vitale, SM Monti, C Pedone, A Scozzafava, A Cecchi, ...
Journal of the American Chemical Society 128 (25), 8329-8335, 2006
1952006
Anticancer carbonic anhydrase inhibitors: a patent review (2008–2013)
SM Monti, CT Supuran, G De Simone
Expert opinion on therapeutic patents 23 (6), 737-749, 2013
1862013
Exploiting the hydrophobic and hydrophilic binding sites for designing carbonic anhydrase inhibitors
G De Simone, V Alterio, CT Supuran
Expert opinion on drug discovery 8 (7), 793-810, 2013
1762013
Carbonic anhydrase IX: Biochemical and crystallographic characterization of a novel antitumor target
G De Simone, CT Supuran
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1804 (2), 404-409, 2010
1662010
Insights into peptide nucleic acid (PNA) structural features: The crystal structure of a d-lysine-based chiral PNA–DNA duplex
V Menchise, G De Simone, T Tedeschi, R Corradini, S Sforza, R Marchelli, ...
Proceedings of the National Academy of Sciences 100 (21), 12021-12026, 2003
1572003
Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies
G De Simone, A Di Fiore, V Menchise, C Pedone, J Antel, A Casini, ...
Bioorganic & medicinal chemistry letters 15 (9), 2315-2320, 2005
1562005
Carbonic anhydrase inhibitors as emerging drugs for the treatment of obesity
CT Supuran, AD Fiore, GD Simone
Expert opinion on emerging drugs 13 (2), 383-392, 2008
1522008
Carbonic anhydrase inhibitors: stacking with Phe131 determines active site binding region of inhibitors as exemplified by the X-ray crystal structure of a membrane-impermeant …
V Menchise, G De Simone, V Alterio, A Di Fiore, C Pedone, A Scozzafava, ...
Journal of medicinal chemistry 48 (18), 5721-5727, 2005
1522005
The crystal structure of a hyper-thermophilic carboxylesterase from the archaeon Archaeoglobus fulgidus
G De Simone, V Menchise, G Manco, L Mandrich, N Sorrentino, D Lang, ...
Journal of molecular biology 314 (3), 507-518, 2001
1482001
Are carbonic anhydrase inhibitors suitable for obtaining antiobesity drugs?
GD Simone, AD Fiore, CT Supuran
Current pharmaceutical design 14 (7), 655-660, 2008
1402008
A snapshot of a transition state analogue of a novel thermophilic esterase belonging to the subfamily of mammalian hormone-sensitive lipase
G De Simone, S Galdiero, G Manco, D Lang, M Rossi, C Pedone
Journal of molecular biology 303 (5), 761-771, 2000
1352000
(In) organic anions as carbonic anhydrase inhibitors
G De Simone, CT Supuran
Journal of inorganic biochemistry 111, 117-129, 2012
1132012
2-substituted estradiol bis-sulfamates, multitargeted antitumor agents: synthesis, in vitro SAR, protein crystallography, and in vivo activity
MP Leese, B Leblond, A Smith, SP Newman, A Di Fiore, G De Simone, ...
Journal of medicinal chemistry 49 (26), 7683-7696, 2006
1002006
Investigations of the esterase, phosphatase, and sulfatase activities of the cytosolic mammalian carbonic anhydrase isoforms I, II, and XIII with 4-nitrophenyl esters as substrates
A Innocenti, A Scozzafava, S Parkkila, L Puccetti, G De Simone, ...
Bioorganic & medicinal chemistry letters 18 (7), 2267-2271, 2008
942008
Carbonic anhydrase inhibitors: hypoxia-activatable sulfonamides incorporating disulfide bonds that target the tumor-associated isoform IX
G De Simone, RM Vitale, A Di Fiore, C Pedone, A Scozzafava, JL Montero, ...
Journal of medicinal chemistry 49 (18), 5544-5551, 2006
932006
Carbonic anhydrase inhibitors: valdecoxib binds to a different active site region of the human isoform II as compared to the structurally related cyclooxygenase II ‘selective …
A Di Fiore, C Pedone, K D’Ambrosio, A Scozzafava, G De Simone, ...
Bioorganic & medicinal chemistry letters 16 (2), 437-442, 2006
922006
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