Alfonso Bueno-Orovio
Alfonso Bueno-Orovio
Department of Computer Science, University of Oxford
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Minimal model for human ventricular action potentials in tissue
A Bueno-Orovio, EM Cherry, FH Fenton
Journal of Theoretical Biology 253 (3), 544-560, 2008
The ‘Digital Twin’ to enable the vision of precision cardiology
J Corral-Acero, F Margara, M Marciniak, C Rodero, F Loncaric, Y Feng, ...
European Heart Journal 41 (18), 4556-4564, 2020
Fourier spectral methods for fractional-in-space reaction-diffusion equations
A Bueno-Orovio, D Kay, K Burrage
BIT Numerical Mathematics 54 (4), 937-954, 2014
Experimentally calibrated population of models predicts and explains intersubject variability in cardiac cellular electrophysiology
OJ Britton, A Bueno-Orovio, K Van Ammel, H Rong Lu, R Towart, ...
Proceedings of the National Academy of Sciences of the United States of …, 2013
Human in silico drug trials demonstrate higher accuracy than animal models in predicting clinical pro-arrhythmic cardiotoxicity
E Passini, OJ Britton, HR Lu, J Rohrbacher, AN Hermans, DJ Gallacher, ...
Frontiers in Physiology 8, 668, 2017
Fractional diffusion models of cardiac electrical propagation: role of structural heterogeneity in dispersion of repolarization
A Bueno-Orovio, D Kay, V Grau, B Rodriguez, K Burrage
Journal of the Royal Society Interface 11 (97), 20140352, 2014
Variability in cardiac electrophysiology: Using experimentally-calibrated populations of models to move beyond the single virtual physiological human paradigm
A Muszkiewicz, OJ Britton, P Gemmell, E Passini, C Sánchez, X Zhou, ...
Progress in Biophysics and Molecular Biology 120 (1-3), 115-127, 2015
Spectral methods for partial differential equations in irregular domains: the spectral smoothed boundary method
A Bueno-Orovio, VM Pérez-García, FH Fenton
SIAM Journal of Scientific Computing 28 (3), 886-900, 2006
Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block
J Tomek, A Bueno-Orovio, E Passini, X Zhou, A Minchole, O Britton, ...
eLife 8, e48890, 2019
Mechanisms of pro-arrhythmic abnormalities in ventricular repolarisation and anti-arrhythmic therapies in human hypertrophic cardiomyopathy
E Passini, A Mincholé, R Coppini, E Cerbai, B Rodriguez, S Severi, ...
Journal of Molecular and Cellular Cardiology 96, 72-81, 2016
Inter-subject variability in human atrial action potential in sinus rhythm versus chronic atrial fibrillation
C Sánchez, A Bueno-Orovio, E Wettwer, S Loose, J Simon, U Ravens, ...
PLoS ONE 9 (8), e105897, 2014
Continuous adjoint approach for the Spalart-Allmaras model in aerodynamic optimization
A Bueno-Orovio, C Castro, F Palacios, E Zuazua
AIAA Journal 50 (3), 631-646, 2012
Na/K pump regulation of cardiac repolarization: insights from a systems biology approach
A Bueno-Orovio, C Sánchez, E Pueyo, B Rodriguez
Pflügers Archiv - European Journal of Physiology 466 (2), 183-193, 2014
Up-regulation of miR-31 in human atrial fibrillation begets the arrhythmia by depleting dystrophin and neuronal nitric oxide synthase
SN Reilly, X Liu, R Carnicer, A Recalde, A Muszkiewicz, R Jayaram, ...
Science Translational Medicine 8 (340), 340ra74, 2016
In vivo and in silico investigation into mechanisms of frequency dependence of repolarization alternans in human ventricular cardiomyocytes
X Zhou, A Bueno-Orovio, M Orini, B Hanson, MP Hayward, P Taggart, ...
Circulation Research 118, 266-278, 2016
Human ventricular activation sequence and the simulation of the electrocardiographic QRS complex and its variability in healthy and intraventricular block conditions
L Cardone-Noott, A Bueno-Orovio, A Minchole, N Zemzemi, B Rodriguez
Europace 18 (suppl_4), iv4-iv15, 2016
General principles for the validation of proarrhythmia risk prediction models: an extension of the CiPA in silico strategy
Z Li, GR Mirams, T Yoshinaga, BJ Ridder, X Han, JE Chen, ...
Clinical Pharmacology & Therapeutics 107 (1), 102-111, 2020
In-silico human electro-mechanical ventricular modelling and simulation for drug-induced pro-arrhythmia and inotropic risk assessment
F Margara, ZJ Wang, F Levrero-Florencio, A Santiago, M Vázquez, ...
Progress in Biophysics and Molecular Biology 159, 58-74, 2021
Toward a broader view of mechanisms of drug cardiotoxicity
P Mamoshina, B Rodriguez, A Bueno-Orovio
Cell Reports Medicine 2 (3), 100216, 2021
Spectral smoothed boundary methods: the role of external boundary conditions
A Bueno‐Orovio, VM Pérez‐García
Numerical Methods for Partial Differential Equations 22 (2), 435-448, 2006
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Artículos 1–20