Roger S. Lo, MD., PhD
Roger S. Lo, MD., PhD
Professor of Medicine, Molecular and Medical Pharmacology
Verified email at
Cited by
Cited by
TGFβ signaling in growth control, cancer, and heritable disorders
J Massagué, SW Blain, RS Lo
Cell 103 (2), 295-309, 2000
Melanomas acquire resistance to B-RAF (V600E) inhibition by RTK or N-RAS upregulation
R Nazarian, H Shi, Q Wang, X Kong, RC Koya, H Lee, Z Chen, MK Lee, ...
Nature 468 (7326), 973-977, 2010
Mutations associated with acquired resistance to PD-1 blockade in melanoma
JM Zaretsky, A Garcia-Diaz, DS Shin, H Escuin-Ordinas, W Hugo, ...
New England Journal of Medicine 375 (9), 819-829, 2016
Genomic and transcriptomic features of response to anti-PD-1 therapy in metastatic melanoma
W Hugo, JM Zaretsky, LU Sun, C Song, BH Moreno, S Hu-Lieskovan, ...
Cell 165 (1), 35-44, 2016
Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
R Straussman, T Morikawa, K Shee, M Barzily-Rokni, ZR Qian, J Du, ...
Nature 487 (7408), 500-504, 2012
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF (V600E)
PI Poulikakos, Y Persaud, M Janakiraman, X Kong, C Ng, G Moriceau, ...
Nature 480 (7377), 387-390, 2011
Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
M Krauthammer, Y Kong, BH Ha, P Evans, A Bacchiocchi, JP McCusker, ...
Nature genetics 44 (9), 1006-1014, 2012
RAS Mutations in Cutaneous Squamous-Cell Carcinomas in Patients Treated with BRAF Inhibitors
F Su, A Viros, C Milagre, K Trunzer, G Bollag, O Spleiss, JS Reis-Filho, ...
New England Journal of Medicine 366 (3), 207-215, 2012
Acquired resistance and clonal evolution in melanoma during BRAF inhibitor therapy
H Shi, W Hugo, X Kong, A Hong, RC Koya, G Moriceau, T Chodon, R Guo, ...
Cancer discovery 4 (1), 80-93, 2014
Interferon receptor signaling pathways regulating PD-L1 and PD-L2 expression
A Garcia-Diaz, DS Shin, BH Moreno, J Saco, H Escuin-Ordinas, ...
Cell reports 19 (6), 1189-1201, 2017
Primary resistance to PD-1 blockade mediated by JAK1/2 mutations
DS Shin, JM Zaretsky, H Escuin-Ordinas, A Garcia-Diaz, S Hu-Lieskovan, ...
Cancer discovery 7 (2), 188-201, 2017
Melanoma whole-exome sequencing identifies V600E B-RAF amplification-mediated acquired B-RAF inhibitor resistance
H Shi, G Moriceau, X Kong, MK Lee, H Lee, RC Koya, C Ng, T Chodon, ...
Nature communications 3 (1), 1-8, 2012
A Smad transcriptional corepressor
D Wotton, RS Lo, S Lee, J Massagué
Cell 97 (1), 29-39, 1999
A structural basis for mutational inactivation of the tumour suppressor Smad4
Y Shi, A Hata, RS Lo, J Massague, NP Pavletich
Nature 388 (6637), 87-93, 1997
Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4
A Hata, RS Lo, D Wotton, G Lagna, J Massague
Nature 388 (6637), 82-87, 1997
Determinants of specificity in TGF-β signal transduction
YG Chen, A Hata, RS Lo, D Wotton, Y Shi, N Pavletich, J Massagué
Genes & development 12 (14), 2144-2152, 1998
Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma
J Müller, O Krijgsman, J Tsoi, L Robert, W Hugo, C Song, X Kong, ...
Nature communications 5 (1), 1-15, 2014
Non-genomic and immune evolution of melanoma acquiring MAPKi resistance
W Hugo, H Shi, L Sun, M Piva, C Song, X Kong, G Moriceau, A Hong, ...
Cell 162 (6), 1271-1285, 2015
Ubiquitin-dependent degradation of TGF-β-activated Smad2
RS Lo, J Massagué
Nature cell biology 1 (8), 472-478, 1999
Pharmacodynamic effects and mechanisms of resistance to vemurafenib in patients with metastatic melanoma
K Trunzer, AC Pavlick, L Schuchter, R Gonzalez, GA McArthur, TE Hutson, ...
Journal of clinical oncology 31 (14), 1767-1774, 2013
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