Kieran Smallbone
Kieran Smallbone
MCISB / Mathematics / Computer Science, University of Manchester
Verified email at - Homepage
Cited by
Cited by
A community-driven global reconstruction of human metabolism
I Thiele, N Swainston, RMT Fleming, A Hoppe, S Sahoo, MK Aurich, ...
Nature biotechnology 31 (5), 419-425, 2013
A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology
MJ Herrgård, N Swainston, P Dobson, WB Dunn, KY Arga, M Arvas, ...
Nature biotechnology 26 (10), 1155-1160, 2008
Cellular adaptations to hypoxia and acidosis during somatic evolution of breast cancer
RA Gatenby, K Smallbone, PK Maini, F Rose, J Averill, RB Nagle, ...
British journal of cancer 97 (5), 646-653, 2007
An assessment of sustainable housing affordability using a multiple criteria decision making method
E Mulliner, K Smallbone, V Maliene
Omega 41 (2), 270-279, 2013
Recon 2.2: from reconstruction to model of human metabolism
N Swainston, K Smallbone, H Hefzi, PD Dobson, J Brewer, M Hanscho, ...
Metabolomics 12 (7), 1-7, 2016
Metabolic changes during carcinogenesis: potential impact on invasiveness
K Smallbone, RA Gatenby, RJ Gillies, PK Maini, DJ Gavaghan
Journal of theoretical biology 244 (4), 703-713, 2007
The role of acidity in solid tumour growth and invasion
K Smallbone, DJ Gavaghan, RA Gatenby, PK Maini
Journal of theoretical biology 235 (4), 476-484, 2005
Towards a genome-scale kinetic model of cellular metabolism
K Smallbone, E Simeonidis, N Swainston, P Mendes
BMC systems biology 4 (1), 6, 2010
Yeast 5 – an expanded reconstruction of the Saccharomyces cerevisiae metabolic network
BD Heavner, K Smallbone, B Barker, P Mendes, LP Walker
BMC Systems Biology 6, 55, 2012
Improving metabolic flux predictions using absolute gene expression data
K Smallbone, D Lee, WB Dunn, E Murabito, CL Winder, DB Kell, ...
BMC Systems Biology 6, 73, 2012
Further developments towards a genome-scale metabolic model of yeast
K Smallbone, P Dobson, D Jameson, E Simeonidis, K Lanthaler, P Pir, ...
BMC Systems Biology 4, 145, 2010
Systematic construction of kinetic models from genome-scale metabolic networks
NJ Stanford, T Lubitz, K Smallbone, E Klipp, P Mendes, W Liebermeister
PloS one 8 (11), e79195, 2013
Something from nothing − bridging the gap between constraint‐based and kinetic modelling
K Smallbone, E Simeonidis, DS Broomhead, DB Kell
FEBS Journal 274 (21), 5576-5585, 2007
A model of yeast glycolysis based on a consistent kinetic characterisation of all its enzymes
K Smallbone, HL Messiha, KM Carroll, CL Winder, N Malys, WB Dunn, ...
FEBS letters 587 (17), 2832-2841, 2013
Version 6 of the consensus yeast metabolic network refines biochemical coverage and improves model performance
BD Heavner, K Smallbone, ND Price, LP Walker
Database 2013, 2013
The SuBliMinaL toolbox: automating steps in the reconstruction of metabolic networks
N Swainston, K Smallbone, P Mendes, D Kell, N Paton
Journal of Integrative Bioinformatics 8 (2), 186, 2011
Flux balance analysis: A geometric perspective
K Smallbone, E Simeonidis
Journal of theoretical biology 258 (2), 311-315, 2009
BioPreDyn-bench: a suite of benchmark problems for dynamic modelling in systems biology
AF Villaverde, D Henriques, K Smallbone, S Bongard, J Schmid, ...
BMC systems biology 9 (1), 1-15, 2015
Metabolic regulation is sufficient for global and robust coordination of glucose uptake, catabolism, energy production and growth in Escherichia coli
P Millard, K Smallbone, P Mendes
PLoS computational biology 13 (2), e1005396, 2017
Large-scale metabolic models: From reconstruction to differential equations
K Smallbone, P Mendes
Industrial Biotechnology 9 (4), 179-184, 2013
Toward community standards and software for whole-cell modeling
D Waltemath, JR Karr, FT Bergmann, V Chelliah, M Hucka, M Krantz, ...
IEEE Transactions on Biomedical Engineering 63 (10), 2007-2014, 2016
Why are (the best) women so good at chess? Participation rates and gender differences in intellectual domains
M Bilalić, K Smallbone, P McLeod, F Gobet
Proceedings of the Royal Society B: Biological Sciences 276 (1659), 1161, 2009
Mathematical modelling of tumour acidity
K Smallbone, RA Gatenby, PK Maini
Journal of theoretical biology 255 (1), 106-112, 2008
SBML Level 3: an extensible format for the exchange and reuse of biological models
SM Keating, D Waltemath, M König, F Zhang, A Dräger, C Chaouiya, ...
Molecular systems biology 16 (8), e9110, 2020
A probabilistic approach to identify putative drug targets in biochemical networks
E Murabito, K Smallbone, J Swinton, HV Westerhoff, R Steuer
Journal of The Royal Society Interface 8 (59), 880-895, 2011
Capturing the essence of a metabolic network: a flux balance analysis approach
E Murabito, E Simeonidis, K Smallbone, J Swinton
Journal of theoretical biology 260 (3), 445-452, 2009
Why does yeast ferment? A flux balance analysis study
E Simeonidis, E Murabito, K Smallbone, HV Westerhoff
Biochemical Society Transactions 38 (5), 1225-1229, 2010
Enzyme kinetics informatics: from instrument to browser
N Swainston, M Golebiewski, HL Messiha, N Malys, R Kania, S Kengne, ...
FEBS Journal 277 (18), 3769-3779, 2010
Episodic, transient systemic acidosis delays evolution of the malignant phenotype: Possible mechanism for cancer prevention by increased physical activity
K Smallbone, PK Maini, RA Gatenby
Biology Direct 5 (22), 2010
A robust and efficient method for estimating enzyme complex abundance and metabolic flux from expression data
BE Barker, N Sadagopan, Y Wang, K Smallbone, CR Myers, H Xi, ...
Computational biology and chemistry 59, 98-112, 2015
Tumour glycolysis: the many faces of HIF
C Kelly, K Smallbone, JM Brady
Journal of theoretical biology 254 (2), 508-513, 2008
Characterisation of multiple substrate-specific (d)ITP/(d)XTPase and modelling of deaminated purine nucleotide metabolism
O Davies, P Mendes, K Smallbone, N Malys
BMB Reports 45 (4), 295-264, 2012
Playing off the curve-testing quantitative predictions of skill acquisition theories in development of chess performance
R Gaschler, J Progscha, K Smallbone, N Ram, M Bilalić
Frontiers in psychology 5, 923, 2014
A mathematical model of the colon crypt capturing compositional dynamic interactions between cell types
K Smallbone, BM Corfe
International journal of experimental pathology 95 (1), 1-7, 2014
Bicarbonate‐rich fluid secretion predicted by a computational model of guinea‐pig pancreatic duct epithelium
M Yamaguchi, MC Steward, K Smallbone, Y Sohma, A Yamamoto, ...
The Journal of physiology 595 (6), 1947-1972, 2017
Enzyme characterisation and kinetic modelling of the pentose phosphate pathway in yeast
HL Messiha, E Kent, N Malys, KM Carroll, N Swainston, P Mendes, ...
PeerJ PrePrints, 2014
Computational Methods in Systems Biology: International Conference CMSB 2007, Edinburgh, Scotland, September 20-21, 2007, Proceedings
M Calder, S Gilmore
Springer, 2007
Building a kinetic model of trehalose biosynthesis in Saccharomyces cerevisiae.
K Smallbone, N Malys, HL Messiha, JA Wishart, E Simeonidis
Methods in Enzymology: Methods in Systems Biology 500, 355, 2011
Striking a balance with Recon 2.1
K Smallbone
arXiv preprint arXiv:1311.5696, 2013
Modelling acidosis and the cell cycle in multicellular tumour spheroids
MJ Tindall, L Dyson, K Smallbone, PK Maini
Journal of Theoretical Biology 298, 107-115, 2012
Quiescence as a mechanism for cyclical hypoxia and acidosis
K Smallbone, DJ Gavaghan, PK Maini, JM Brady
Journal of mathematical biology 55 (5), 767-779, 2007
Computational Methods in Systems Biology
P Mendes, JO Dada, K Smallbone
Springer, 2014
Kinetic modelling of metabolic pathways: application to serine biosynthesis
K Smallbone, NJ Stanford
Systems Metabolic Engineering : Methods and Protocols 985, 113-121, 2013
Kinetic modelling of large-scale metabolic networks
P Mendes, NJ Stanford, K Smallbone
Proceedings of the 9th International Conference on Computational Methods in …, 2011
Multi-scale modelling of E. coli metabolism
P Millard, K Smallbone
PeerJ 3, e1128, 2015
Modelling aspects of tumour metabolism
PK Maini, RA Gatenby, K Smallbone
International Congress of Mathematicians, 2010
A model to investigate the feasibility of FDG as a surrogate marker of hypoxia
CJ Kelly, K Smallbone, T Roose, JM Brady
Biomedical Imaging: From Nano to Macro, 2007. ISBI 2007. 4th IEEE …, 2007
Standardized network reconstruction of E. coli metabolism
K Smallbone
arXiv preprint arXiv:1304.2960, 2013
Size dependent growth in metabolic networks
H Dorrian, J Borresen, K Smallbone
arXiv preprint arXiv:1210.2550, 2012
Kinetic modelling of metabolic pathways
NJ Stanford, K Smallbone
The Bioinformatics Knowledgeblog, 2011
Constraint-based optimisation tools for semi-automated refinement of genome-scale yeast metabolic models
P Pir, PD Dobson, K Smallbone, P Mendes, RD King, C Lu, SG Oliver, ...
The role of acidity in tumour development
K Smallbone
Mathematising biology
K Smallbone, Y Wang
Manchester Institute for Mathematical Sciences, University of Manchester, 2015
BioPreDyn-bench: a suite of benchmark problems for dynamic modelling in systems biology
JR Banga, J Jaeger, P Mendes, E Balsa-Canto, K Mauch, ...
BioPreDyn-bench: a suite of benchmark problems for dynamic modelling in systems biology–Supplementary Information
AF Villaverde, D Henriques, K Smallbone, S Bongard, J Schmid, ...
Metabolic Control Analysis: Rereading Reder
K Smallbone
arXiv preprint arXiv:1305.6449, 2013
MIMS EPrint: 2015.57 Manchester Institute for Mathematical Sciences School of Mathematics
K Smallbone, HL Messiha, KM Carroll, CL Winder, N Malys, WB Dunn, ...
FEBS Letters 587, 2832-2841, 2013
Modelling of metabolic control by Short Chain Fatty Acids at the level of the functional proteome – II: systems biology model of SCFA metabolism
BM Corfe, CA Evans, E Murabito, K Smallbone
Proceedings of the Nutrition Society 72 (OCE4), 2013
Mechanistic modelling of cancer: some reflections from software engineering and philosophy of science
JM Cañete-Valdeón, R Wieringa, K Smallbone
Naturwissenschaften 99 (12), 973-983, 2012
Why do Patients get Metachronous Colorectal Adenomas?
JP Bury, S Riley, CA Evans, EA Williams, CA Staton, E Murabito, ...
Journal of Pathology 228, S3, 2012
Dave Broomhead's 60th Birthday
M Muldoon, J Huke, K Smallbone
Mathematics Today 47 (2), 68-69, 2011
One lump or two?
K Smallbone
Nature Publishing Group, 2009
Perfect numbers over simple algebraic number fields
K Smallbone
SPORTING NEWS 223 (37), 39, 1999
M Bilalic, K Smallbone, P McLeod, F Gobet
This painting by Dutch artist Lucas van Leyden (1494–1533) very aptly illustrates our subject
M Bilalic, K Smallbone, P McLeod, F Gobet
Towards the digital Escherichia coli
P Millard, K Smallbone, M Manca, P Mendes
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