Roderick Hubbard
Roderick Hubbard
University of York and Vernalis (R&D) Ltd
Verified email at
Cited by
Cited by
Molecular basis of agonism and antagonism in the oestrogen receptor
AM Brzozowski, ACW Pike, Z Dauter, RE Hubbard, T Bonn, O Engström, ...
Nature 389 (6652), 753-758, 1997
Hydrogen bonding in globular proteins
EN Baker, RE Hubbard
Progress in biophysics and molecular biology 44 (2), 97-179, 1984
Structural model of ATP-binding proteing associated with cystic fibrosis, multidrug resistance and bacterial transport
SC Hyde, P Emsley, MJ Hartshorn, MM Mimmack, U Gileadi, SR Pearce, ...
Nature 346 (6282), 362-365, 1990
Structure of the ligand‐binding domain of oestrogen receptor beta in the presence of a partial agonist and a full antagonist
ACW Pike, AM Brzozowski, RE Hubbard, T Bonn, AG Thorsell, ...
The EMBO journal, 1999
Twenty years on: the impact of fragments on drug discovery
DA Erlanson, SW Fesik, RE Hubbard, W Jahnke, H Jhoti
Nature reviews Drug discovery 15 (9), 605-619, 2016
The structure of 2Zn pig insulin crystals at 1.5 Å resolution
EN Baker, TL Blundell, JF Cutfield, EJ Dodson, GG Dodson, ...
Philosophical Transactions of the Royal Society of London. B, Biological …, 1988
Glycosaminoglycans interact selectively with chemokines and modulate receptor binding and cellular responses
GSV Kuschert, F Coulin, CA Power, AEI Proudfoot, RE Hubbard, ...
Biochemistry 38 (39), 12959-12968, 1999
NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis
SA Eccles, A Massey, FI Raynaud, SY Sharp, G Box, M Valenti, ...
Cancer research 68 (8), 2850-2860, 2008
rDock: a fast, versatile and open source program for docking ligands to proteins and nucleic acids
S Ruiz-Carmona, D Alvarez-Garcia, N Foloppe, AB Garmendia-Doval, ...
PLoS computational biology 10 (4), e1003571, 2014
4, 5-diarylisoxazole Hsp90 chaperone inhibitors: potential therapeutic agents for the treatment of cancer
PA Brough, W Aherne, X Barril, J Borgognoni, K Boxall, JE Cansfield, ...
Journal of medicinal chemistry 51 (2), 196-218, 2008
Structural insights into the mode of action of a pure antiestrogen
ACW Pike, AM Brzozowski, J Walton, RE Hubbard, AG Thorsell, YL Li, ...
Structure 9 (2), 145-153, 2001
Hydrogen bonds in proteins: role and strength
RE Hubbard, MK Haider
eLS, 2010
Biophysics in drug discovery: impact, challenges and opportunities
JP Renaud, C Chung, UH Danielson, U Egner, M Hennig, RE Hubbard, ...
Nature reviews Drug discovery 15 (10), 679-698, 2016
Heat-stable antifreeze protein from grass
C Sidebottom, S Buckley, P Pudney, S Twigg, C Jarman, C Holt, J Telford, ...
Nature 406 (6793), 256-256, 2000
HOOK: a program for finding novel molecular architectures that satisfy the chemical and steric requirements of a macromolecule binding site
MB Eisen, DC Wiley, M Karplus, RE Hubbard
Proteins: Structure, Function, and Bioinformatics 19 (3), 199-221, 1994
Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms
L Wright, X Barril, B Dymock, L Sheridan, A Surgenor, M Beswick, ...
Chemistry & biology 11 (6), 775-785, 2004
Novel, potent small-molecule inhibitors of the molecular chaperone Hsp90 discovered through structure-based design
BW Dymock, X Barril, PA Brough, JE Cansfield, A Massey, E McDonald, ...
Journal of medicinal chemistry 48 (13), 4212-4215, 2005
Towards predictive ligand design with free-energy based computational methods?
N Foloppe, R Hubbard
Current medicinal chemistry 13 (29), 3583-3608, 2006
Identification of a glycosaminoglycan binding surface on human interleukin-8
GSV Kuschert, AJ Hoogewerf, AEI Proudfoot, C Chung, RM Cooke, ...
Biochemistry 37 (32), 11193-11201, 1998
A structural biologist's view of the oestrogen receptor
ACW Pike, AM Brzozowski, RE Hubbard
The Journal of steroid biochemistry and molecular biology 74 (5), 261-268, 2000
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