Follow
Tushar Shakya
Tushar Shakya
Verified email at mcmaster.ca
Title
Cited by
Cited by
Year
Synthesis and Structure−Activity Relationships of Truncated Bisubstrate Inhibitors of Aminoglycoside 6‘-N-Acetyltransferases
F Gao, X Yan, T Shakya, OM Baettig, S Ait-Mohand-Brunet, AM Berghuis, ...
Journal of medicinal chemistry 49 (17), 5273-5281, 2006
1142006
A small molecule discrimination map of the antibiotic resistance kinome
T Shakya, PJ Stogios, N Waglechner, E Evdokimova, L Ejim, ...
Chemistry & Biology 18 (12), 1591-1601, 2011
882011
Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance
PJ Stogios, P Spanogiannopoulos, E Evdokimova, O Egorova, T Shakya, ...
Biochemical Journal 454 (2), 191-200, 2013
572013
Inhibition of the ANT (2 ″)-Ia resistance enzyme and rescue of aminoglycoside antibiotic activity by synthetic α-hydroxytropolones
DR Hirsch, G Cox, MP D’Erasmo, T Shakya, C Meck, N Mohd, GD Wright, ...
Bioorganic & medicinal chemistry letters 24 (21), 4943-4947, 2014
512014
Nucleotide selectivity of antibiotic kinases
T Shakya, GD Wright
Antimicrobial agents and chemotherapy 54 (5), 1909-1913, 2010
432010
Structure and Function of APH (4)-Ia, a Hygromycin B Resistance Enzyme*♦
PJ Stogios, T Shakya, E Evdokimova, A Savchenko, GD Wright
Journal of biological chemistry 286 (3), 1966-1975, 2011
392011
Microwave-assisted synthesis of N1-and C3-substituted pyrazolo [3, 4-d] pyrimidine libraries
N Todorovic, E Awuah, T Shakya, GD Wright, A Capretta
Tetrahedron letters 52 (44), 5761-5763, 2011
362011
Mechanisms of aminoglycoside antibiotic resistance
T Shakya, GD Wright
Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery, 119-140, 2007
212007
Identification and characterization of new inhibitors of fungal homoserine kinase
G De Pascale, EJ Griffiths, T Shakya, I Nazi, GD Wright
ChemBioChem 12 (8), 1179-1182, 2011
82011
GD Wright in Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery
T Shakya
John Wiley & Sons, Hoboken, 2007
72007
A chemical biology approach to probing aminoglycoside phosphotransferase structure and function
T Shakya, GD Wright
BIOCHEMISTRY AND CELL BIOLOGY-BIOCHIMIE ET BIOLOGIE CELLULAIRE 86 (2), 193-193, 2008
2008
The system can't perform the operation now. Try again later.
Articles 1–11