Hazel M Girvan
Hazel M Girvan
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Variations on a (t) heme—novel mechanisms, redox partners and catalytic functions in the cytochrome P450 superfamily
AW Munro, HM Girvan, KJ McLean
Natural product reports 24 (3), 585-609, 2007
Applications of microbial cytochrome P450 enzymes in biotechnology and synthetic biology
HM Girvan, AW Munro
Current opinion in chemical biology 31, 136-145, 2016
Cytochrome P450–redox partner fusion enzymes
AW Munro, HM Girvan, KJ McLean
Biochimica et Biophysica Acta (BBA)-General Subjects 1770 (3), 345-359, 2007
What makes a P450 tick?
AW Munro, HM Girvan, AE Mason, AJ Dunford, KJ McLean
Trends in biochemical sciences 38 (3), 140-150, 2013
The dimeric form of flavocytochrome P450 BM3 is catalytically functional as a fatty acid hydroxylase
R Neeli, HM Girvan, A Lawrence, MJ Warren, D Leys, NS Scrutton, ...
FEBS letters 579 (25), 5582-5588, 2005
Heme sensor proteins
HM Girvan, AW Munro
Journal of Biological Chemistry 288 (19), 13194-13203, 2013
Flavocytochrome P450 BM3: an update on structure and mechanism of a biotechnologically important enzyme
AJ Warman, O Roitel, R Neeli, HM Girvan, HE Seward, SA Murray, ...
Biochemical Society Transactions 33 (4), 747-753, 2005
Biophysical Characterization of the Sterol Demethylase P450 from Mycobacterium tuberculosis, Its Cognate Ferredoxin, and Their Interactions
KJ McLean, AJ Warman, HE Seward, KR Marshall, HM Girvan, ...
Biochemistry 45 (27), 8427-8443, 2006
Flavocytochrome P450 BM3 mutant A264E undergoes substrate-dependent formation of a novel heme iron ligand set
HM Girvan, KR Marshall, RJ Lawson, D Leys, MG Joyce, J Clarkson, ...
Journal of Biological Chemistry 279 (22), 23274-23286, 2004
Structural and spectroscopic characterization of P450 BM3 mutants with unprecedented P450 heme iron ligand sets: new heme ligation states influence conformational equilibria in …
HM Girvan, HE Seward, HS Toogood, MR Cheesman, D Leys, AW Munro
Journal of Biological Chemistry 282 (1), 564-572, 2007
A single mutation in cytochrome P450 BM3 induces the conformational rearrangement seen upon substrate binding in the wild-type enzyme
MG Joyce, HM Girvan, AW Munro, D Leys
Journal of Biological Chemistry 279 (22), 23287-23293, 2004
Catalytic determinants of alkene production by the cytochrome P450 peroxygenase OleTJE
S Matthews, JD Belcher, KL Tee, HM Girvan, KJ McLean, SEJ Rigby, ...
Journal of Biological Chemistry 292 (12), 5128-5143, 2017
The crystal structure of the FAD/NADPH‐binding domain of flavocytochrome P450 BM3
MG Joyce, IS Ekanem, O Roitel, AJ Dunford, R Neeli, HM Girvan, ...
The FEBS journal 279 (9), 1694-1706, 2012
Flavocytochrome P450 BM3 and the origin of CYP102 fusion species
HM Girvan, TN Waltham, R Neeli, HF Collins, KJ McLean, NS Scrutton, ...
Biochemical Society Transactions 34 (6), 1173-1177, 2006
Flavocytochrome P450 BM3 mutant W1046A is a NADH-dependent fatty acid hydroxylase: implications for the mechanism of electron transfer in the P450 BM3 dimer
HM Girvan, AJ Dunford, R Neeli, IS Ekanem, TN Waltham, MG Joyce, ...
Archives of biochemistry and biophysics 507 (1), 75-85, 2011
Interaction of nitric oxide with cytochrome P450 BM3
LG Quaroni, HE Seward, KJ McLean, HM Girvan, TWB Ost, MA Noble, ...
Biochemistry 43 (51), 16416-16431, 2004
Cytochrome P450/redox partner fusion enzymes: biotechnological and toxicological prospects
KJ McLean, HM Girvan, AW Munro
Expert opinion on drug metabolism & toxicology 3 (6), 847-863, 2007
Novel haem co-ordination variants of flavocytochrome P450 BM3
HM Girvan, HS Toogood, RE Littleford, HE Seward, WE Smith, IS Ekanem, ...
Biochemical Journal 417 (1), 65-80, 2009
Heme and hemoproteins
AW Munro, HM Girvan, KJ McLean, MR Cheesman, D Leys
Tetrapyrroles: Birth, Life and Death, 160-183, 2009
Clobetasol propionate is a heme-mediated selective inhibitor of human cytochrome P450 3A5
WC Wright, J Chenge, J Wang, HM Girvan, L Yang, SC Chai, AD Huber, ...
Journal of medicinal chemistry 63 (3), 1415-1433, 2020
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