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John Steele
John Steele
Independent
Verified email at steele5.com
Title
Cited by
Cited by
Year
Combinatorial synthesis—the design of compound libraries and their application to drug discovery
NK Terrett, M Gardner, DW Gordon, RJ Kobylecki, J Steele
Tetrahedron 51 (30), 8135-8173, 1995
9511995
Reductive alkylation on a solid phase: Synthesis of a piperazinedione combinatorial library
DW Gordon, J Steele
Bioorganic & Medicinal Chemistry Letters 5 (1), 47-50, 1995
2311995
1, 4-Dihydropyridines as antagonists of platelet activating factor. 1. Synthesis and structure-activity relationships of 2-(4-heterocyclyl) phenyl derivatives
K Cooper, MJ Fray, MJ Parry, K Richardson, J Steele
Journal of medicinal chemistry 35 (17), 3115-3129, 1992
1471992
Components of successful lead generation
AM Davis, DJ Keeling, J Steele, NP Tomkinson, AC Tinker
Current topics in medicinal chemistry 5 (4), 421-439, 2005
1342005
Drug-like properties: guiding principles for design–or chemical prejudice?
PD Leeson, AM Davis, J Steele
Drug Discovery Today: Technologies 1 (3), 189-195, 2004
1062004
Rate enhancement of biomimetic polyene cyclizations by a cation-stabilizing auxiliary
WS Johnson, SD Lindell, J Steele
Journal of the American Chemical Society 109 (19), 5852-5853, 1987
1001987
New Lewis-Acidic Molybdenum (II) and Tungsten (II) Catalysts for Intramolecular Carbonyl Ene and Prins Reactions. Reversal of the Stereoselectivity of Cyclization of Citronellal
P Kočovskı, G Ahmed, J Šrogl, AV Malkov, J Steele
The Journal of organic chemistry 64 (8), 2765-2775, 1999
941999
Asymmetric synthesis via acetal templates. 12. Highly diastereoselective coupling reactions with a ketene acetal. An efficient, asymmetric synthesis of R-(+)-α-lipoic acid
JD Elliott, J Steele, WS Johnson
Tetrahedron letters 26 (21), 2535-2538, 1985
741985
A mild and selective C-3 reductive alkylation of indoles
JE Appleton, KN Dack, AD Green, J Steele
Tetrahedron letters 34 (9), 1529-1532, 1993
651993
The combinatorial synthesis of a 30,752-compound library: discovery of SAR around the endothelin antagonist, FR-139,317
NK Terrett, D Bojanic, D Brown, PJ Bungay, M Gardner, DW Gordon, ...
Bioorganic & Medicinal Chemistry Letters 5 (9), 917-922, 1995
601995
Selective Non-steroidal Glucocorticoid Receptor Modulators for the Inhaled Treatment of Pulmonary Diseases
M Hemmerling, S Nilsson, K Edman, S Eirefelt, W Russell, R Hendrickx, ...
Journal of Medicinal Chemistry, 2017
542017
Discovery of potent & selective inhibitors of activated thrombin-activatable fibrinolysis inhibitor for the treatment of thrombosis
ME Bunnage, J Blagg, J Steele, DR Owen, C Allerton, AB McElroy, ...
Journal of medicinal chemistry 50 (24), 6095-6103, 2007
532007
Novel antagonists of platelet-activating factor. 1. Synthesis and structure-activity relationships of benzodiazepine and benzazepine derivatives of 2-methyl-1-phenylimidazo [4 …
MJ Fray, K Cooper, MJ Parry, K Richardson, J Steele
Journal of medicinal chemistry 38 (18), 3514-3523, 1995
511995
A Practical Method for Targeted Library Design Balancing Lead‐like Properties with Diversity
MJ Stocks, GRH Wilden, G Pairaudeau, MWD Perry, J Steele, ...
ChemMedChem: Chemistry Enabling Drug Discovery 4 (5), 800-808, 2009
452009
Thromboxane modulating agents. 3. 1 H-Imidazol-1-ylalkyl-and 3-pyridinylalkyl-substituted 3-[2-[(arylsulfonyl) amino] ethyl] benzenepropanoic acid derivatives as dual …
RP Dickinson, KN Dack, CJ Long, J Steele
Journal of medicinal chemistry 40 (21), 3442-3452, 1997
331997
Indole derivatives thromboxane A2 antagonists
PE Cross, KN Dack, RP Dickinson, J Steele
US Patent 5,744,488, 1998
311998
Drug discovery by combinatorial chemistry—the development of a novel method for the rapid synthesis of single compounds
NK Terrett, M Gardner, DW Gordon, RJ Kobylecki, J Steele
Chemistry-A European Journal 3 (12), 1917-1920, 1997
291997
Pyrimidine derivatives as modulators of chemokine receptor activity
MR Ebden, P Meghani, AR Cook, J Steele, LLS Cheema
US Patent 7,482,355, 2009
262009
Discovery of AZD-2098 and AZD-1678, two potent and bioavailable CCR4 receptor antagonists
N Kindon, G Andrews, A Baxter, D Cheshire, P Hemsley, T Johnson, ...
ACS Medicinal Chemistry Letters 8 (9), 981-986, 2017
202017
Discovery and evaluation of a novel monocyclic series of CXCR2 antagonists
RP Austin, C Bennion, RV Bonnert, L Cheema, AR Cook, RJ Cox, ...
Bioorganic & medicinal chemistry letters 25 (7), 1616-1620, 2015
142015
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