jan paul medema
jan paul medema
Hoogleraar Exp Oncology and Radiobiology
Geverifieerd e-mailadres voor amc.nl - Homepage
TitelGeciteerd doorJaar
Guidelines for the use and interpretation of assays for monitoring autophagy
DJ Klionsky, FC Abdalla, H Abeliovich, RT Abraham, A Acevedo-Arozena, ...
Autophagy 8 (4), 445-544, 2012
Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
L Vermeulen, EM Felipe De Sousa, M Van Der Heijden, K Cameron, ...
Nature cell biology 12 (5), 468, 2010
The consensus molecular subtypes of colorectal cancer
J Guinney, R Dienstmann, X Wang, A De Reyniès, A Schlicker, ...
Nature medicine 21 (11), 1350, 2015
FLICE is activated by association with the CD95 death‐inducing signaling complex (DISC)
JP Medema, C Scaffidi, FC Kischkel, A Shevchenko, M Mann, ...
The EMBO journal 16 (10), 2794-2804, 1997
Colon cancer stem cells dictate tumor growth and resist cell death by production of interleukin-4
M Todaro, MP Alea, AB Di Stefano, P Cammareri, L Vermeulen, F Iovino, ...
Cell stem cell 1 (4), 389-402, 2007
Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity
L Vermeulen, M Todaro, F de Sousa Mello, MR Sprick, K Kemper, ...
Proceedings of the National Academy of Sciences 105 (36), 13427-13432, 2008
Essential versus accessory aspects of cell death: recommendations of the NCCD 2015
L Galluzzi, JM Bravo-San Pedro, I Vitale, SA Aaronson, JM Abrams, ...
Cell death and differentiation 22 (1), 58, 2015
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
L Galluzzi, I Vitale, SA Aaronson, JM Abrams, D Adam, P Agostinis, ...
Cell Death & Differentiation 25 (3), 486-541, 2018
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes
L Galluzzi, SA Aaronson, J Abrams, ES Alnemri, DW Andrews, ...
Cell death and differentiation 16 (8), 1093, 2009
Cancer stem cells: the challenges ahead
JP Medema
Nature cell biology 15 (4), 338-344, 2013
Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions
EM Felipe De Sousa, X Wang, M Jansen, E Fessler, A Trinh, ...
Nature medicine 19 (5), 614, 2013
Cancer stem cell niche: the place to be
T Borovski, EM Felipe De Sousa, L Vermeulen, JP Medema
Cancer research 71 (3), 634-639, 2011
FLICE is predominantly expressed as two functionally active isoforms, caspase-8/a and caspase-8/b
C Scaffidi, JP Medema, PH Krammer, ME Peter
Journal of Biological Chemistry 272 (43), 26953-26958, 1997
Microenvironmental regulation of stem cells in intestinal homeostasis and cancer
JP Medema, L Vermeulen
Nature 474 (7351), 318, 2011
Colon cancer stem cells: promise of targeted therapy
M Todaro, MG Francipane, JP Medema, G Stassi
Gastroenterology 138 (6), 2151-2162, 2010
Sequential cancer mutations in cultured human intestinal stem cells
J Drost, RH Van Jaarsveld, B Ponsioen, C Zimberlin, R Van Boxtel, ...
Nature 521 (7550), 43, 2015
Immune escape of tumors in vivo by expression of cellular FLICE-inhibitory protein
JP Medema, J de Jong, T van Hall, CJM Melief, R Offringa
Journal of Experimental Medicine 190 (7), 1033-1038, 1999
Blockade of the granzyme B/perforin pathway through overexpression of the serine protease inhibitor PI-9/SPI-6 constitutes a mechanism for immune escape by tumors
JP Medema, J De Jong, LTC Peltenburg, EME Verdegaal, A Gorter, ...
Proceedings of the National Academy of Sciences 98 (20), 11515-11520, 2001
Cancer stem cells–old concepts, new insights
L Vermeulen, MR Sprick, K Kemper, G Stassi, JP Medema
Cell death and differentiation 15 (6), 947, 2008
The AC133 epitope, but not the CD133 protein, is lost upon cancer stem cell differentiation
K Kemper, MR Sprick, M de Bree, A Scopelliti, L Vermeulen, M Hoek, ...
Cancer research 70 (2), 719-729, 2010
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