Gavin Whitlock
Gavin Whitlock
Sandexis
Verified email at sandexis.co.uk
TitleCited byYear
Intramolecular hydrogen bonding to improve membrane permeability and absorption in beyond rule of five chemical space
A Alex, DS Millan, M Perez, F Wakenhut, GA Whitlock
MedChemComm 2 (7), 669-674, 2011
1362011
Catalytic asymmetric hydroboration with heterotopic PN ligands: Trends in enantioselectivity with increased steric demand
JM Valk, GA Whitlock, TP Layzell, JM Brown
Tetrahedron: Asymmetry 6 (10), 2593-2596, 1995
1041995
Rapid discovery of a novel series of Abl kinase inhibitors by application of an integrated microfluidic synthesis and screening platform
B Desai, K Dixon, E Farrant, Q Feng, KR Gibson, WP van Hoorn, J Mills, ...
Journal of medicinal chemistry 56 (7), 3033-3047, 2013
642013
Enantioselective synthesis of ent-stellettamide A via a novel dipolar cycloaddition reaction of (Trimethylsilyl) diazomethane
GA Whitlock, EM Carreira
The Journal of organic chemistry 62 (23), 7916-7917, 1997
631997
A short synthesis of ()-decarestrictine L
JS Clark, GA Whitlock
Tetrahedron letters 35 (34), 6381-6382, 1994
611994
Asymmetric synthesis of cyclic ethers by rearrangement of oxonium ylides generated from chiral copper carbenoids
JS Clark, M Fretwell, GA Whitlock, CJ Burns, DNA Fox
Tetrahedron letters 39 (1-2), 97-100, 1998
601998
A concise enantioselective synthesis of the fungal metabolite (+)-decarestrictine L
JS Clark, TC Fessard, GA Whitlock
Tetrahedron 62 (1), 73-78, 2006
522006
Potent and selective nonpeptidic inhibitors of procollagen C-proteinase
PV Fish, GA Allan, S Bailey, J Blagg, R Butt, MG Collis, D Greiling, ...
Journal of medicinal chemistry 50 (15), 3442-3456, 2007
492007
Enantioselective Synthesis of ent‐Stellettamide A: Asymmetric Dipolar Cycloadditions with Me3SiCHN2
GA Whitlock, EM Carreira
Helvetica chimica acta 83 (8), 2007-2022, 2000
432000
Design and synthesis of morpholine derivatives. SAR for dual serotonin & noradrenaline reuptake inhibition
PV Fish, C Deur, X Gan, K Greene, D Hoople, M Mackenny, KS Para, ...
Bioorganic & medicinal chemistry letters 18 (8), 2562-2566, 2008
392008
Chloroquine–astemizole hybrids with potent in vitro and in vivo antiplasmodial activity
CC Musonda, GA Whitlock, MJ Witty, R Brun, M Kaiser
Bioorganic & medicinal chemistry letters 19 (2), 481-484, 2009
362009
Synthesis and evaluation of 2-pyridyl pyrimidines with in vitro antiplasmodial and antileishmanial activity
CC Musonda, GA Whitlock, MJ Witty, R Brun, M Kaiser
Bioorganic & medicinal chemistry letters 19 (2), 401-405, 2009
352009
Compounds
PV Fish, MJ Fray, A Stobie, F Wakenhut, GA Whitlock, MD Andrews, ...
US Patent 7,378,436, 2008
312008
Discovery of a novel azepine series of potent and selective 5-HT 2C agonists as potential treatments for urinary incontinence
PE Brennan, GA Whitlock, DKH Ho, K Conlon, G McMurray
Bioorganic & medicinal chemistry letters 19 (17), 4999-5003, 2009
292009
N-(1, 2-Diphenylethyl) piperazines: A new class of dual serotonin/noradrenaline reuptake inhibitor
MJ Fray, G Bish, AD Brown, PV Fish, A Stobie, F Wakenhut, GA Whitlock
Bioorganic & medicinal chemistry letters 16 (16), 4345-4348, 2006
292006
Novel amino-pyrazole ureas with potent in vitro and in vivo antileishmanial activity
CE Mowbray, S Braillard, W Speed, PA Glossop, GA Whitlock, KR Gibson, ...
Journal of medicinal chemistry 58 (24), 9615-9624, 2015
282015
Novel compounds
P Fish, M MacKenny, A Stobie, F Wakenhut, G Whitlock
US Patent App. 11/117,896, 2005
272005
Understanding CYP2D6 interactions
MJ de Groot, F Wakenhut, G Whitlock, R Hyland
Drug discovery today 14 (19-20), 964-972, 2009
262009
Pyridyl-phenyl ether monoamine reuptake inhibitors: impact of lipophilicity on dual SNRI pharmacology and off-target promiscuity
GA Whitlock, PV Fish, MJ Fray, A Stobie, F Wakenhut
Bioorganic & medicinal chemistry letters 18 (9), 2896-2899, 2008
262008
1-(2-Phenoxyphenyl) methanamines: SAR for dual serotonin/noradrenaline reuptake inhibition, metabolic stability and hERG affinity
GA Whitlock, J Blagg, PV Fish
Bioorganic & medicinal chemistry letters 18 (2), 596-599, 2008
262008
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