Demonstrating in-cell target engagement using a pirin protein degradation probe (CCT367766) NEA Chessum, SY Sharp, JJ Caldwell, AE Pasqua, B Wilding, ... Journal of medicinal chemistry 61 (3), 918-933, 2018 | 48 | 2018 |
Nitrile reductase from Geobacillus kaustophilus: a potential catalyst for a new nitrile biotransformation reaction B Wilding, M Winkler, B Petschacher, R Kratzer, A Glieder, N Klempier Advanced Synthesis & Catalysis 354 (11‐12), 2191-2198, 2012 | 31 | 2012 |
Discovery of a Chemical Probe Bisamide (CCT251236): An Orally Bioavailable Efficacious Pirin Ligand from a Heat Shock Transcription Factor 1 (HSF1) Phenotypic Screen Journal of Medicinal Chemistry 60 (1), 180-201, 2017 | 27 | 2017 |
Targeting the Substrate Binding Site of E. coli Nitrile Reductase QueF by Modeling, Substrate and Enzyme Engineering B Wilding, M Winkler, B Petschacher, R Kratzer, S Egger, G Steinkellner, ... Chemistry–A European Journal 19 (22), 7007-7012, 2013 | 23 | 2013 |
An investigation of nitrile transforming enzymes in the chemo-enzymatic synthesis of the taxol sidechain B Wilding, AB Veselá, JJB Perry, GW Black, M Zhang, L Martínková, ... Organic & biomolecular chemistry 13 (28), 7803-7812, 2015 | 15 | 2015 |
Newest Developments in the Preparation of Thieno[2,3-d]pyrimidines B Wilding, N Klempier Organic Preparations and Procedures International 49 (3), 183-215, 2017 | 14 | 2017 |
A practical synthesis of 5-functionalized thieno [2, 3-d] pyrimidines B Wilding, S Faschauner, N Klempier Tetrahedron letters 56 (30), 4486-4489, 2015 | 12 | 2015 |
A convenient synthetic route to substituted pyrrolo [2, 3-b] pyridines via a novel ethylene-bridged compound B Wilding, C Vidovic, N Klempier Tetrahedron letters 56 (47), 6606-6609, 2015 | 7 | 2015 |
Privileged structures and polypharmacology within and between protein families J Meyers, NEA Chessum, S Ali, NY Mok, B Wilding, AE Pasqua, ... ACS medicinal chemistry letters 9 (12), 1199-1204, 2018 | 6 | 2018 |
Kinetic analysis and probing with substrate analogues of the reaction pathway of the nitrile reductase QueF from Escherichia coli J Jung, T Czabany, B Wilding, N Klempier, B Nidetzky Journal of Biological Chemistry 291 (49), 25411-25426, 2016 | 5 | 2016 |
The Nitrile‐Forming Enzyme 7‐Cyano‐7‐Deazaguanine Synthase from Geobacillus kaustophilus: A Reverse Nitrilase? M Winkler, K Dokulil, H Weber, T Pavkov‐Keller, B Wilding ChemBioChem 16 (16), 2373-2378, 2015 | 3 | 2015 |
Quinoline derivatives as inhibitors of heat shock factor 1 pathway activity K Jones, M Cheeseman, N Chessum, E Pasqua, L Evans, M Tucker, ... US Patent 10,647,678, 2020 | | 2020 |
Confirmation of in-cell target engagement using the proteolysis targeting chimeras (PROTACs) against pirin SY Sharp, NE Chessum, JJ Caldwell, MV Powers, AE Pasqua, B Wilding, ... Cancer Research 78 (13 Supplement), 2976-2976, 2018 | | 2018 |
Discovery of CCT251236 from an HSF1 phenotypic screen: A pirin ligand with efficacy in an ovarian adenocarcinoma model E Pasqua, M Cheeseman, N Chessum, C Rye, M Tucker, B Wilding, ... ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 253, 2017 | | 2017 |
Targeting Protein Synthesis, Folding, and Degradation Pathways in Cancer AE Pasqua, B Wilding, MD Cheeseman, K Jones Elsevier, 2017 | | 2017 |
Enzymatic Reductions of unconventioal substrates: Carboxylates and Nitriles M Winkler, K Napora-Wijata, B Wilding, N Klempier | | 2014 |
Unconventional Enzymatic Reductions: Nitriles and Carboxylates as Substrates M Winkler, K Napora-Wijata, B Wilding, N Klempier | | 2014 |
In Vitro Reconstruction of Queuosine biosynthesis in Geobacillus kaustophilus: two step cascade from 7-carboxy-7-deazaguanin to PreQ1 K Dokulil, B Wilding, G Offenmüller, N Klempier, M Winkler | | 2014 |
Book Review: The Weirdness of Being R Winkler Indo-Pacific Journal of Phenomenology 14 (2), 2014 | | 2014 |
Biological nitrile reduction–exploring a remarkable reaction B Wilding, B Petschacher, M Winkler, R Kratzer, G Steinkellner, ... 15th Austrian Chemistry Days 2013, 2013 | | 2013 |