Simon Cook
Simon Cook
Signalling Programme, The Babraham Institute
Verified email at babraham.ac.uk - Homepage
TitleCited byYear
Inhibition by cAMP of Ras-dependent activation of Raf
SJ Cook, F McCormick
Science 262 (5136), 1069-1072, 1993
10371993
Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim
R Ley, K Balmanno, K Hadfield, C Weston, SJ Cook
Journal of Biological Chemistry 278 (21), 18811-18816, 2003
6402003
Characterization of two alternately spliced forms of phospholipase D1 activation of the purified enzymes by phosphatidylinositol 4, 5-bisphosphate, ADP-ribosylation factor, and …
SM Hammond, JM Jenco, S Nakashima, K Cadwallader, Q Gu, S Cook, ...
Journal of Biological Chemistry 272 (6), 3860-3868, 1997
5481997
Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival
HL Roderick, SJ Cook
Nature Reviews Cancer 8 (5), 361, 2008
5452008
Rap1V12 antagonises Ras-dependent activation of ERK1 & ERK2 by LPA and EGF in Rat-1 fibroblasts
S Cook, B Rubinfeld, F Albert, I & McCormick
EMBO Journal 12, 3475-3485, 1993
4001993
Tumour cell survival signalling by the ERK1/2 pathway
K Balmanno, SJ Cook
Cell death and differentiation 16 (3), 368, 2009
3942009
Regulatory phosphorylation of Bim: sorting out the ERK from the JNK
R Ley, KE Ewings, K Hadfield, SJ Cook
Cell death and differentiation 12 (8), 1008, 2005
3272005
FGF signaling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency
G Ficz, TA Hore, F Santos, HJ Lee, W Dean, J Arand, F Krueger, D Oxley, ...
Cell stem cell 13 (3), 351-359, 2013
2962013
Sustained MAP kinase activation is required for the expression of cyclin D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cells
K Balmanno, SJ Cook
Oncogene 18 (20), 3085, 1999
2671999
Paclitaxel-induced nuclear translocation of FOXO3a in breast cancer cells is mediated by c-Jun NH2-terminal kinase and Akt
A Sunters, PA Madureira, KM Pomeranz, M Aubert, JJ Brosens, SJ Cook, ...
Cancer research 66 (1), 212-220, 2006
2472006
MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road
CJ Caunt, MJ Sale, PD Smith, SJ Cook
Nature Reviews Cancer 15, 577–592, 2015
2302015
Extracellular signal-regulated kinases 1/2 are serum-stimulated “BimEL kinases” that bind to the BH3-only protein BimEL causing its phosphorylation and turnover
R Ley, KE Ewings, K Hadfield, E Howes, K Balmanno, SJ Cook
Journal of Biological Chemistry 279 (10), 8837-8847, 2004
2282004
The repertoire of fos and jun proteins expressed during the G1 phase of the cell cycle is determined by the duration of mitogen-activated protein kinase activation
SJ Cook, N Aziz, M McMahon
Molecular and Cellular Biology 19 (1), 330-341, 1999
2201999
The selective protein kinase C inhibitor, Ro-31-8220, inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression, and activates Jun N …
J Beltman, F McCormick, SJ Cook
Journal of Biological Chemistry 271 (43), 27018-27024, 1996
2091996
Activation of ERK1/2 by ΔRaf-1: ER* represses Bim expression independently of the JNK or PI3K pathways
CR Weston, K Balmanno, C Chalmers, K Hadfield, SA Molton, R Ley, ...
Oncogene 22 (9), 1281, 2003
2042003
Analysis of the water-soluble products of phosphatidylcholine breakdown by ion-exchange chromatography. Bombesin and TPA (12-O-tetradecanoylphorbol 13-acetate) stimulate …
SJ Cook, MJO Wakelam
Biochemical Journal 263 (2), 581-587, 1989
2031989
Nucleotide-binding oligomerization domain-1 and epidermal growth factor receptor critical regulators of β-defensins during Helicobacter pylori infection
PK Boughan, RH Argent, M Body-Malapel, JH Park, KE Ewings, ...
Journal of Biological Chemistry 281 (17), 11637-11648, 2006
1942006
The role of MAPK signalling pathways in the response to endoplasmic reticulum stress
NJ Darling, SJ Cook
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1843 (10), 2150-2163, 2014
1862014
ERK1/2‐dependent phosphorylation of BimEL promotes its rapid dissociation from Mcl‐1 and Bcl‐xL
KE Ewings, K Hadfield‐Moorhouse, CM Wiggins, JA Wickenden, ...
The EMBO journal 26 (12), 2856-2867, 2007
1812007
De-regulated FGF receptors as therapeutic targets in cancer
V Knights, SJ Cook
Pharmacology & therapeutics 125 (1), 105-117, 2010
1742010
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Articles 1–20