Simon Cook
Simon Cook
Signalling Laboratory, The Babraham Institute
Verified email at - Homepage
Cited by
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Inhibition by cAMP of Ras-dependent activation of Raf
SJ Cook, F McCormick
Science 262 (5136), 1069-1072, 1993
Activation of the ERK1/2 signaling pathway promotes phosphorylation and proteasome-dependent degradation of the BH3-only protein, Bim
R Ley, K Balmanno, K Hadfield, C Weston, SJ Cook
Journal of Biological Chemistry 278 (21), 18811-18816, 2003
Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival
HL Roderick, SJ Cook
Nature Reviews Cancer 8 (5), 361-375, 2008
Characterization of two alternately spliced forms of phospholipase D1: activation of the purified enzymes by phosphatidylinositol 4, 5-bisphosphate, ADP-ribosylation factor …
SM Hammond, JM Jenco, S Nakashima, K Cadwallader, Q Gu, S Cook, ...
Journal of Biological Chemistry 272 (6), 3860-3868, 1997
Tumour cell survival signalling by the ERK1/2 pathway
K Balmanno, SJ Cook
Cell Death & Differentiation 16 (3), 368-377, 2009
Rap1V12 antagonises Ras-dependent activation of ERK1 & ERK2 by LPA and EGF in Rat-1 fibroblasts
S Cook, B Rubinfeld, F Albert, I & McCormick
EMBO Journal 12, 3475-3485, 1993
FGF signaling inhibition in ESCs drives rapid genome-wide demethylation to the epigenetic ground state of pluripotency
G Ficz, TA Hore, F Santos, HJ Lee, W Dean, J Arand, F Krueger, D Oxley, ...
Cell stem cell 13 (3), 351-359, 2013
Regulatory phosphorylation of Bim: sorting out the ERK from the JNK.
R Ley, KE Ewings, K Hadfield, SJ Cook
Cell death and differentiation 12 (8), 1008-1014, 2005
MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road
CJ Caunt, MJ Sale, PD Smith, SJ Cook
Nature Reviews Cancer 15, 577–592, 2015
Sustained MAP kinase activation is required for the expression of cyclin D1, p21 Cip1 and a subset of AP-1 proteins in CCL39 cells
K Balmanno, SJ Cook
Oncogene 18 (20), 3085-3097, 1999
Paclitaxel-induced nuclear translocation of FOXO3a in breast cancer cells is mediated by c-Jun NH2-terminal kinase and Akt
A Sunters, PA Madureira, KM Pomeranz, M Aubert, JJ Brosens, SJ Cook, ...
Cancer research 66 (1), 212-220, 2006
The role of MAPK signalling pathways in the response to endoplasmic reticulum stress
NJ Darling, SJ Cook
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1843 (10), 2150-2163, 2014
The repertoire of fos and jun proteins expressed during the G1 phase of the cell cycle is determined by the duration of mitogen-activated protein kinase activation
SJ Cook, N Aziz, M McMahon
Molecular and Cellular Biology 19 (1), 330-341, 1999
Extracellular signal-regulated kinases 1/2 are serum-stimulated “BimEL kinases” that bind to the BH3-only protein BimEL causing its phosphorylation and turnover
R Ley, KE Ewings, K Hadfield, E Howes, K Balmanno, SJ Cook
Journal of Biological Chemistry 279 (10), 8837-8847, 2004
Analysis of the water-soluble products of phosphatidylcholine breakdown by ion-exchange chromatography. Bombesin and TPA (12-O-tetradecanoylphorbol 13 …
SJ Cook, MJO Wakelam
Biochemical Journal 263 (2), 581-587, 1989
Activation of ERK1/2 by ΔRaf-1: ER* represses Bim expression independently of the JNK or PI3K pathways
CR Weston, K Balmanno, C Chalmers, K Hadfield, SA Molton, R Ley, ...
Oncogene 22 (9), 1281-1293, 2003
The selective protein kinase C inhibitor, Ro-31-8220, inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) expression, induces c-Jun expression, and activates Jun N …
J Beltman, F McCormick, SJ Cook
Journal of Biological Chemistry 271 (43), 27018-27024, 1996
Nucleotide-binding oligomerization domain-1 and epidermal growth factor receptor: critical regulators of β-defensins during Helicobacter pylori infection
PK Boughan, RH Argent, M Body-Malapel, JH Park, KE Ewings, ...
Journal of Biological Chemistry 281 (17), 11637-11648, 2006
Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells
AS Little, K Balmanno, MJ Sale, S Newman, JR Dry, M Hampson, ...
Science signaling 4 (166), ra17-ra17, 2011
De-regulated FGF receptors as therapeutic targets in cancer
V Knights, SJ Cook
Pharmacology & therapeutics 125 (1), 105-117, 2010
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