Inhibitors and Inactivators of Protein Arginine Deiminase 4: Functional and Structural Characterization, Y Luo, K Arita, M Bhatia, B Knuckley, YH Lee, MR Stallcup, M Sato, ... Biochemistry 45 (39), 11727-11736, 2006 | 327 | 2006 |
N-α-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis VC Willis, AM Gizinski, NK Banda, CP Causey, B Knuckley, KN Cordova, ... The Journal of Immunology 186 (7), 4396-4404, 2011 | 323 | 2011 |
Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential J Jones, C Causey, B Knuckley, JL Slack-Noyes, PR Thompson Current opinion in drug discovery & development 12 (5), 616, 2009 | 269 | 2009 |
Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor AA Chumanevich, CP Causey, BA Knuckley, JE Jones, D Poudyal, ... American Journal of Physiology-Gastrointestinal and Liver Physiology 300 (6 …, 2011 | 217 | 2011 |
Substrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3 B Knuckley, CP Causey, JE Jones, M Bhatia, CJ Dreyton, TC Osborne, ... Biochemistry 49 (23), 4852-4863, 2010 | 189 | 2010 |
A fluoroacetamidine-based inactivator of protein arginine deiminase 4: design, synthesis, and in vitro and in vivo evaluation Y Luo, B Knuckley, YH Lee, MR Stallcup, PR Thompson Journal of the American Chemical Society 128 (4), 1092-1093, 2006 | 172 | 2006 |
Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular chromatin traps N Dwivedi, J Upadhyay, I Neeli, S Khan, D Pattanaik, L Myers, KA Kirou, ... Arthritis & rheumatism 64 (4), 982-992, 2012 | 156 | 2012 |
Protein arginine deiminase 4: evidence for a reverse protonation mechanism B Knuckley, M Bhatia, PR Thompson Biochemistry 46 (22), 6578-6587, 2007 | 113 | 2007 |
Profiling Protein Arginine Deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors B Knuckley, Y Luo, PR Thompson Bioorganic & medicinal chemistry 16 (2), 739-745, 2008 | 106 | 2008 |
A fluopol-ABPP HTS assay to identify PAD inhibitors B Knuckley, JE Jones, DA Bachovchin, J Slack, CP Causey, SJ Brown, ... Chemical communications 46 (38), 7175-7177, 2010 | 102 | 2010 |
The development of N-α-(2-carboxyl) benzoyl-N 5-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl) benzoyl-N 5-(2-chloro-1-iminoethyl)-l-ornithine … CP Causey, JE Jones, JL Slack, D Kamei, LE Jones Jr, V Subramanian, ... Journal of medicinal chemistry 54 (19), 6919-6935, 2011 | 92 | 2011 |
Activity-based protein profiling reagents for protein arginine deiminase 4 (PAD4): synthesis and in vitro evaluation of a fluorescently labeled probe Y Luo, B Knuckley, M Bhatia, PJ Pellechia, PR Thompson Journal of the American Chemical Society 128 (45), 14468-14469, 2006 | 85 | 2006 |
Haloacetamidine‐based inactivators of protein arginine deiminase 4 (PAD4): evidence that general acid catalysis promotes efficient inactivation B Knuckley, CP Causey, PJ Pellechia, PF Cook, PR Thompson Chembiochem 11 (2), 161-165, 2010 | 66 | 2010 |
Post-training lesions of the medial prefrontal cortex interfere with subsequent performance of trace eyeblink conditioning B Simon, B Knuckley, J Churchwell, DA Powell Journal of Neuroscience 25 (46), 10740-10746, 2005 | 51 | 2005 |
Mechanistic studies of protein arginine deiminase 2: evidence for a substrate-assisted mechanism CJ Dreyton, B Knuckley, JE Jones, DM Lewallen, PR Thompson Biochemistry 53 (27), 4426-4433, 2014 | 43 | 2014 |
Prefrontal control of trace versus delay eyeblink conditioning: role of the unconditioned stimulus in rabbits (Oryctolagus cuniculus). B Oswald, B Knuckley, K Mahan, C Sanders, DA Powell Behavioral neuroscience 120 (5), 1033, 2006 | 42 | 2006 |
Two distinct cyclodipeptide synthases from a marine actinomycete catalyze biosynthesis of the same diketopiperazine natural product ED James, B Knuckley, N Alqahtani, S Porwal, J Ban, JA Karty, ... ACS Synthetic Biology 5 (7), 547-553, 2016 | 38 | 2016 |
Probing adenylation: using a fluorescently labelled ATP probe to directly label and immunoprecipitate VopS substrates DM Lewallen, CJ Steckler, B Knuckley, MJ Chalmers, PR Thompson Molecular BioSystems 8 (6), 1701-1706, 2012 | 37 | 2012 |
Characterization and inactivation of an agmatine deiminase from Helicobacter pylori JE Jones, CP Causey, L Lovelace, B Knuckley, H Flick, L Lebioda, ... Bioorganic chemistry 38 (2), 62-73, 2010 | 28 | 2010 |
Galantamine facilitates acquisition of a trace-conditioned eyeblink response in healthy, young rabbits BB Simon, B Knuckley, DA Powell Learning & Memory 11 (1), 116-122, 2004 | 27 | 2004 |