| The expanding family of interleukin-1 cytokines and their role in destructive inflammatory disorders HE Barksby, SR Lea, PM Preshaw, JJ Taylor Clinical & Experimental Immunology 149 (2), 217-225, 2007 | 508 | 2007 |
| Characterisation of lung macrophage subpopulations in COPD patients and controls JA Dewhurst, S Lea, E Hardaker, JV Dungwa, AK Ravi, D Singh Scientific reports 7 (1), 7143, 2017 | 115 | 2017 |
| Airway host-microbiome interactions in chronic obstructive pulmonary disease Z Wang, B Maschera, S Lea, U Kolsum, D Michalovich, S Van Horn, ... Respiratory research 20, 1-14, 2019 | 112 | 2019 |
| The effect of peroxisome proliferator-activated receptor-γ ligands on in vitro and in vivo models of COPD S Lea, J Plumb, H Metcalfe, D Spicer, P Woodman, JC Fox, D Singh European Respiratory Journal 43 (2), 409-420, 2014 | 111 | 2014 |
| Effects of cigarette smoke on Toll-like receptor (TLR) activation of chronic obstructive pulmonary disease (COPD) macrophages HJ Metcalfe, S Lea, D Hughes, R Khalaf, K Abbott-Banner, D Singh Clinical & Experimental Immunology 176 (3), 461-472, 2014 | 104 | 2014 |
| Synergistic effects of p38 mitogen-activated protein kinase inhibition with a corticosteroid in alveolar macrophages from patients with chronic obstructive pulmonary disease J Armstrong, C Harbron, S Lea, G Booth, P Cadden, KA Wreggett, ... Journal of Pharmacology and Experimental Therapeutics 338 (3), 732-740, 2011 | 98 | 2011 |
| Pivotal advance: vasoactive intestinal peptide inhibits up-regulation of human monocyte TLR2 and TLR4 by LPS and differentiation of monocytes to macrophages N Foster, SR Lea, PM Preshaw, JJ Taylor Journal of Leucocyte Biology 81 (4), 893-903, 2007 | 83 | 2007 |
| IFN‐γ synergistically enhances LPS signalling in alveolar macrophages from COPD patients and controls by corticosteroid‐resistant STAT1 activation T Southworth, A Metryka, S Lea, S Farrow, J Plumb, D Singh British journal of pharmacology 166 (7), 2070-2083, 2012 | 72 | 2012 |
| Down regulation of T cell receptor expression in COPD pulmonary CD8 cells S Grundy, J Plumb, S Lea, M Kaur, D Ray, D Singh PloS one 8 (8), e71629, 2013 | 49 | 2013 |
| Bacteria and sputum inflammatory cell counts; a COPD cohort analysis AS Beech, S Lea, U Kolsum, Z Wang, BE Miller, GC Donaldson, ... Respiratory research 21, 1-13, 2020 | 46 | 2020 |
| RV568, a narrow-spectrum kinase inhibitor with p38 MAPK-α and-γ selectivity, suppresses COPD inflammation CE Charron, P Russell, K Ito, S Lea, Y Kizawa, C Brindley, D Singh European Respiratory Journal 50 (4), 2017 | 46 | 2017 |
| The effects of corticosteroids on COPD lung macrophages: a pooled analysis A Higham, G Booth, S Lea, T Southworth, J Plumb, D Singh Respiratory research 16, 1-9, 2015 | 45 | 2015 |
| Mechanisms of corticosteroid insensitivity in COPD alveolar macrophages exposed to NTHi RM Khalaf, SR Lea, HJ Metcalfe, D Singh Respiratory research 18, 1-10, 2017 | 42 | 2017 |
| The role of the liver X receptor in chronic obstructive pulmonary disease A Higham, S Lea, J Plumb, B Maschera, K Simpson, D Ray, D Singh Respiratory research 14, 1-15, 2013 | 37 | 2013 |
| The effects of repeated Toll-like receptors 2 and 4 stimulation in COPD alveolar macrophages SR Lea, SL Reynolds, M Kaur, KD Simpson, SR Hall, EM Hessel, D Singh International journal of chronic obstructive pulmonary disease, 771-780, 2018 | 35 | 2018 |
| P38 MAPK and glucocorticoid receptor crosstalk in bronchial epithelial cells S Lea, J Li, J Plumb, K Gaffey, S Mason, R Gaskell, C Harbron, D Singh Journal of Molecular Medicine 98, 361-374, 2020 | 34 | 2020 |
| The modulatory effects of the PDE4 inhibitors CHF6001 and roflumilast in alveolar macrophages and lung tissue from COPD patients S Lea, A Metryka, J Li, A Higham, C Bridgewood, G Villetti, M Civelli, ... Cytokine 123, 154739, 2019 | 33 | 2019 |
| Diesel exhaust particle exposure in vitro alters monocyte differentiation and function N Chaudhuri, H Jary, S Lea, N Khan, KC Piddock, DH Dockrell, ... Plos one 7 (12), e51107, 2012 | 32 | 2012 |
| Leukotriene B4 levels in sputum from asthma patients A Higham, P Cadden, T Southworth, M Rossall, U Kolsum, S Lea, ... ERJ Open Research 2 (4), 2016 | 31 | 2016 |
| Corticosteroid insensitive alveolar macrophages from asthma patients; synergistic interaction with a p38 mitogen‐activated protein kinase (MAPK) inhibitor S Lea, C Harbron, N Khan, G Booth, J Armstrong, D Singh British journal of clinical pharmacology 79 (5), 756-766, 2015 | 31 | 2015 |
