Targeting the IGF-1R: the tale of the tortoise and the hare C Crudden, A Girnita, L Girnita Frontiers in endocrinology 6, 139855, 2015 | 87 | 2015 |
The forces driving cancer extracellular vesicle secretion MP Bebelman, E Janssen, DM Pegtel, C Crudden Neoplasia 23 (1), 149-157, 2021 | 51 | 2021 |
The dichotomy of the Insulin-like growth factor 1 receptor: RTK and GPCR: friend or foe for cancer treatment? C Crudden, M Ilic, N Suleymanova, C Worrall, A Girnita, L Girnita Growth Hormone & IGF Research 25 (1), 2-12, 2015 | 42 | 2015 |
Unbalancing p53/Mdm2/IGF-1R axis by Mdm2 activation restrains the IGF-1-dependent invasive phenotype of skin melanoma C Worrall, N Suleymanova, C Crudden, I Trocoli Drakensjö, E Candrea, ... Oncogene 36 (23), 3274-3286, 2017 | 39 | 2017 |
Functional antagonism of β-arrestin isoforms balance IGF-1R expression and signalling with distinct cancer-related biological outcomes N Suleymanova, C Crudden, T Shibano, C Worrall, I Oprea, A Tica, ... Oncogene 36 (41), 5734-5744, 2017 | 38 | 2017 |
Below the surface: IGF-1R therapeutic targeting and its endocytic journey C Crudden, D Song, S Cismas, E Trocmé, S Pasca, GA Calin, A Girnita, ... Cells 8 (10), 1223, 2019 | 35 | 2019 |
Genome-wide screen for microRNAs reveals a role for miR-203 in melanoma metastasis W Lohcharoenkal, KD Mahapatra, L Pasquali, C Crudden, L Kular, ... Journal of Investigative Dermatology 138 (4), 882-892, 2018 | 35 | 2018 |
Blurring boundaries: receptor tyrosine kinases as functional G protein-coupled receptors C Crudden, T Shibano, D Song, N Suleymanova, A Girnita, L Girnita International review of cell and molecular biology 339, 1-40, 2018 | 33 | 2018 |
Chapter seven-when phosphorylation encounters ubiquitination: a balanced perspective on IGF-1R signaling L Girnita, SI Takahashi, C Crudden, T Fukushima, C Worrall, H Furuta, ... Progress in molecular biology and translational science 141, 277-311, 2016 | 24 | 2016 |
The convergence of extracellular vesicle and GPCR biology MP Bebelman, C Crudden, DM Pegtel, MJ Smit Trends in pharmacological sciences 41 (9), 627-640, 2020 | 22 | 2020 |
Enhanced response of melanoma cells to MEK inhibitors following unbiased IGF-1R down-regulation N Suleymanova, C Crudden, C Worrall, A Dricu, A Girnita, L Girnita Oncotarget 8 (47), 82256, 2017 | 20 | 2017 |
Inhibition of G Protein–Coupled Receptor Kinase 2 Promotes Unbiased Downregulation of IGF1 Receptor and Restrains Malignant Cell Growth C Crudden, T Shibano, D Song, MP Dragomir, S Cismas, J Serly, ... Cancer research 81 (2), 501-514, 2021 | 17 | 2021 |
IGF-1R is a molecular determinant for response to p53 reactivation therapy in conjunctival melanoma D Song, S Cismas, C Crudden, E Trocme, C Worrall, N Suleymanova, ... Oncogene 41 (4), 600-611, 2022 | 10 | 2022 |
The tale of a tail: The secret behind IGF-1R’s oncogenic power C Crudden, L Girnita Science signaling 13 (633), eabb7887, 2020 | 7 | 2020 |
Exosomal release of the virus-encoded chemokine receptor US28 contributes to chemokine scavenging MP Bebelman, IM Setiawan, ND Bergkamp, JR van Senten, C Crudden, ... iScience 26 (8), 2023 | 1 | 2023 |
Differential Regulation of IGF-1 and Insulin Signaling by GRKs L Girnita, A Girnita, C Crudden G Protein-Coupled Receptor Kinases, 151-171, 2016 | 1 | 2016 |
Competing engagement of β-arrestin isoforms balances IGF1R/p53 signaling and controls melanoma cell chemotherapeutic responsiveness S Cismas, S Pasca, C Crudden, I Trocoli Drakensjo, N Suleymanova, ... Molecular cancer research 21 (12), 1288-1302, 2023 | | 2023 |
Correction: IGF-1R is a molecular determinant for response to p53 reactivation therapy in conjunctival melanoma D Song, S Cismas, C Crudden, E Trocme, C Worrall, N Suleymanova, ... Oncogene 42 (11), 858-858, 2023 | | 2023 |
Luminescence-based screening for extracellular vesicle release modulators reveals a role for PI4KIIIβ in exosome biogenesis upon lysosome inhibition MP Bebelman, C Crudden, B Snieder, E Thanou, CJM Langedijk, M Viola, ... bioRxiv, 2023.02. 23.529257, 2023 | | 2023 |
26653 Can β-arrestin isoforms control response of melanoma cells to chemotherapy? A Girnita, C Crudden, N Suleymanova, L Girnita Journal of the American Academy of Dermatology 85 (3), AB111, 2021 | | 2021 |