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Mark Rackham
Mark Rackham
Distinguished Researcher, Isomorphic Labs
Verified email at isomorphiclabs.com
Title
Cited by
Cited by
Year
Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach
MH Wright, B Clough, MD Rackham, K Rangachari, JA Brannigan, ...
Nature chemistry 6 (2), 112-121, 2014
2412014
Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2
A Mares, AH Miah, IED Smith, M Rackham, AR Thawani, J Cryan, ...
Communications biology 3 (1), 140, 2020
1782020
A caged E3 ligase ligand for PROTAC-mediated protein degradation with light
CS Kounde, MM Shchepinova, CN Saunders, M Muelbaier, MD Rackham, ...
Chemical Communications 56 (41), 5532-5535, 2020
1082020
Discovery of Novel and Ligand-Efficient Inhibitors of Plasmodium falciparum and Plasmodium vivaxN-Myristoyltransferase
MD Rackham, JA Brannigan, DK Moss, Z Yu, AJ Wilkinson, AA Holder, ...
Journal of Medicinal Chemistry 56 (1), 371-375, 2013
832013
Design and Synthesis of High Affinity Inhibitors of Plasmodium falciparum and Plasmodium vivax N-Myristoyltransferases Directed by Ligand Efficiency Dependent …
MD Rackham, JA Brannigan, K Rangachari, S Meister, AJ Wilkinson, ...
Journal of Medicinal Chemistry 57 (6), 2773-2788, 2014
822014
N-Myristoyltransferase as a potential drug target in malaria and leishmaniasis
EW Tate, AS Bell, MD Rackham, MH Wright
Parasitology 141 (1), 37-49, 2014
822014
Optimization of a series of RIPK2 PROTACs
AH Miah, IED Smith, M Rackham, A Mares, AR Thawani, R Nagilla, ...
Journal of Medicinal Chemistry 64 (17), 12978-13003, 2021
542021
Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase
MD Rackham, Z Yu, JA Brannigan, WP Heal, D Paape, KV Barker, ...
MedChemComm 6 (10), 1761-1766, 2015
352015
Bicyclic AZA compounds as muscarinic M1 receptor and/or M4 receptor agonists
GA Brown, JE Cansfield, MS Congreve, MA O'brien, M Pickworth, ...
US Patent 9,670,183, 2017
292017
Muscarinic agonists
GA Brown, MS Congreve, M Pickworth, MD Rackham, BG Tehan
US Patent 10,548,884, 2020
132020
Bicyclic aza compounds as muscarinic M1 receptor and/or M4 receptor agonists
GA Brown, JE Cansfield, MS Congreve, MA O'brien, M Pickworth, ...
US Patent 10,196,380, 2019
132019
Bicyclic AZA compounds as muscarinic M1 receptor and/or M4 receptor agonists
GA Brown, JE Cansfield, MS Congreve, MA O'brien, M Pickworth, ...
US Patent 9,926,297, 2018
122018
Bicyclic aza compounds as muscarnic M1 receptor and/or M4 receptor antagonists
GA Brown, JE Cansfield, MS Congreve, MA O'brien, M Pickworth, ...
US Patent 10,385,039, 2019
92019
Bicyclic aza compounds as muscarinic M1 receptor and/or M4 receptor
GA Brown, JE Cansfield, MS Congreve, MA O'brien, M Pickworth, ...
US Patent 10,689,368, 2020
82020
Bicyclic AZA compounds as muscarinic M1 receptor and/or M4 receptor
GA Brown, JE Cansfield, MS Congreve, MA O'brien, M Pickworth, ...
US Patent 10,961,225, 2021
72021
Compounds
LN Casillas, JD Harling, AH Miah, MD Rackham, IED Smith
US Patent 10,435,391, 2019
72019
Muscarinic agonists
GA Brown, MS Congreve, M Pickworth, MD Rackham, BG Tehan
US Patent 11,324,738, 2022
62022
Conjugates comprising RIPK2 inhibitors
LN Casillas, JD Harling, AH Miah, MD Rackham, IED Smith
US Patent 10,781,205, 2020
42020
Novel compounds and their use in therapy
R Leatherbarrow, E Tate, Z Yu, M Racklam
London Patent WO 83991, 13, 2013
42013
Bicyclic aza compounds as muscarinic m1 receptor agonists.
GA Brown, JE Cansfield, MS Congreve, MA O'brien, M PICKWORTH, ...
22015
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