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Mark Rackham
Mark Rackham
Distinguished Researcher, Isomorphic Labs
Verified email at isomorphiclabs.com
Title
Cited by
Cited by
Year
Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach
MH Wright, B Clough, MD Rackham, K Rangachari, JA Brannigan, ...
Nature chemistry 6 (2), 112-121, 2014
2122014
Extended pharmacodynamic responses observed upon PROTAC-mediated degradation of RIPK2
A Mares, AH Miah, IED Smith, M Rackham, AR Thawani, J Cryan, ...
Communications biology 3 (1), 140, 2020
1422020
A caged E3 ligase ligand for PROTAC-mediated protein degradation with light
CS Kounde, MM Shchepinova, CN Saunders, M Muelbaier, MD Rackham, ...
Chemical communications 56 (41), 5532-5535, 2020
872020
N-Myristoyltransferase as a potential drug target in malaria and leishmaniasis
EW Tate, AS Bell, MD Rackham, MH Wright
Parasitology 141 (1), 37-49, 2014
782014
Design and Synthesis of High Affinity Inhibitors of Plasmodium falciparum and Plasmodium vivax N-Myristoyltransferases Directed by Ligand Efficiency Dependent …
MD Rackham, JA Brannigan, K Rangachari, S Meister, AJ Wilkinson, ...
Journal of Medicinal Chemistry 57 (6), 2773-2788, 2014
742014
Discovery of Novel and Ligand-Efficient Inhibitors of Plasmodium falciparum and Plasmodium vivaxN-Myristoyltransferase
MD Rackham, JA Brannigan, DK Moss, Z Yu, AJ Wilkinson, AA Holder, ...
Journal of Medicinal Chemistry 56 (1), 371-375, 2013
732013
Discovery of high affinity inhibitors of Leishmania donovani N-myristoyltransferase
MD Rackham, Z Yu, JA Brannigan, WP Heal, D Paape, KV Barker, ...
MedChemComm 6 (10), 1761-1766, 2015
332015
Optimization of a series of RIPK2 PROTACs
AH Miah, IED Smith, M Rackham, A Mares, AR Thawani, R Nagilla, ...
Journal of Medicinal Chemistry 64 (17), 12978-13003, 2021
322021
Compounds
LN Casillas, JD Harling, AH Miah, MD Rackham, IED Smith
US Patent 10,435,391, 2019
62019
Conjugates comprising RIPK2 inhibitors
LN Casillas, JD Harling, AH Miah, MD Rackham, IED Smith
US Patent 10,781,205, 2020
42020
Novel compounds and their use in therapy
R Leatherbarrow, E Tate, Z Yu, M Racklam
London Patent WO 83991, 13, 2013
42013
The medicinal chemistry of mitochondrial dysfunction: a critical overview of efforts to modulate mitochondrial health
MTW Lee, W Mahy, MD Rackham
RSC Medicinal Chemistry 12 (8), 1281-1311, 2021
12021
Conjugates comprising ripk2 inhibitors
LN Casillas, JD Harling, AH MIAH, IED Smith, MD RACKHAM
12017
Novel compounds
LN Casillas, JD Harling, AH Miah, MD Rackham, IED Smith
US Patent App. 16/547,734, 2019
2019
Conjugates comprising ripk2 inhibitors
LN Casillas, JD Harling, AH MIAH, IED Smith, MD RACKHAM
2019
Design and synthesis of N-Myristoyltransferase inhibitors: a promising treatment for malaria
M Rackham
Imperial College London, 2012
2012
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