yan yan
yan yan
Postdoctoral Fellow at Van Andel Institute
Verified email at vai.org
TitleCited byYear
EZH2: biology, disease, and structure-based drug discovery
J Tan, Y Yan, X Wang, Y Jiang, HE Xu
Acta Pharmacologica Sinica 35 (2), 161, 2014
1152014
Amyloid beta: structure, biology and structure-based therapeutic development
G Chen, T Xu, Y Yan, Y Zhou, Y Jiang, K Melcher, HE Xu
Acta Pharmacologica Sinica 38 (9), 1205, 2017
872017
Alzheimer’s disease-associated mutations increase amyloid precursor protein resistance to γ-secretase cleavage and the Aβ42/Aβ40 ratio
TH Xu, Y Yan, Y Kang, Y Jiang, K Melcher, HE Xu
Cell discovery 2, 16026, 2016
352016
Deconvoluting AMP-activated protein kinase (AMPK) adenine nucleotide binding and sensing
X Gu, Y Yan, SJ Novick, A Kovach, D Goswami, J Ke, MHE Tan, L Wang, ...
Journal of Biological Chemistry 292 (30), 12653-12666, 2017
212017
Dimerization of the transmembrane domain of amyloid precursor protein is determined by residues around the γ-secretase cleavage sites
Y Yan, TH Xu, KG Harikumar, LJ Miller, K Melcher, HE Xu
Journal of Biological Chemistry 292 (38), 15826-15837, 2017
162017
Structure and physiological regulation of AMPK
Y Yan, XE Zhou, HE Xu, K Melcher
International journal of molecular sciences 19 (11), 3534, 2018
92018
Defining the minimum substrate and charge recognition model of gamma-secretase
Y Yan, TH Xu, K Melcher, HE Xu
Acta Pharmacologica Sinica 38 (10), 1412, 2017
92017
A highly sensitive non-radioactive activity assay for AMP-activated protein kinase (AMPK)
Y Yan, X Gu, HE Xu, K Melcher
Methods and protocols 1 (1), 3, 2018
32018
Structures of AMP-activated protein kinase bound to novel pharmacological activators in phosphorylated, non-phosphorylated, and nucleotide-free states
Y Yan, XE Zhou, SJ Novick, SJ Shaw, Y Li, JS Brunzelle, Y Hitoshi, ...
Journal of Biological Chemistry 294 (3), 953-967, 2019
22019
Bioluminescence Resonance Energy Transfer (BRET) Assay for Determination of Molecular Interactions in Living Cells
KG Harikumar, Y Yan, TH Xu, K Melcher, HE Xu, LJ Miller
Bio-protocol 7 (22), 2017
22017
Conformational heterogeneity of the allosteric drug and metabolite (ADaM) site in AMP-activated protein kinase (AMPK)
X Gu, MD Bridges, Y Yan, PW de Waal, XE Zhou, KM Suino-Powell, ...
Journal of Biological Chemistry 293 (44), 16994-17007, 2018
12018
Detection of Membrane Protein Interactions by Cell-based Tango Assays
Y Yan, TH Xu, KG Harikumar, LJ Miller, K Melcher, HE Xu
Bio-protocol 7 (22), 2017
12017
Streptavidin Bead Pulldown Assay to Determine Protein Homooligomerization
TH Xu, Y Yan, KG Harikumar, LJ Miller, K Melcher, HE Xu
Bio-protocol 7 (22), 2017
12017
γ-Secretase Epsilon-cleavage Assay
TH Xu, Y Yan, KG Harikumar, LJ Miller, K Melcher, HE Xu
Bio-protocol 7 (22), 2017
2017
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