Mode of action of kanglemycin A, an ansamycin natural product that is active against rifampicin-resistant Mycobacterium tuberculosis H Mosaei, V Molodtsov, B Kepplinger, J Harbottle, CW Moon, RE Jeeves, ... Molecular cell 72 (2), 263-274. e5, 2018 | 57 | 2018 |
Mode of action and heterologous expression of the natural product antibiotic vancoresmycin B Kepplinger, S Morton-Laing, KH Seistrup, ECL Marrs, AP Hopkins, ... ACS chemical biology 13 (1), 207-214, 2017 | 55 | 2017 |
Structure and mechanism of an inverting alkylsulfatase from Pseudomonas sp. DSM6611 specific for secondary alkyl sulfates T Knaus, M Schober, B Kepplinger, M Faccinelli, J Pitzer, K Faber, ... The FEBS journal 279 (23), 4374-4384, 2012 | 29 | 2012 |
Production of 17-O-demethyl-geldanamycin, a cytotoxic ansamycin polyketide, by Streptomyces hygroscopicus DEM20745 A Baksh, B Kepplinger, HA Isah, MR Probert, W Clegg, C Wills, ... Natural product research 31 (16), 1895-1900, 2017 | 8 | 2017 |
Systematic whole-genome sequencing reveals an unexpected diversity among actinomycetoma pathogens and provides insights into their antibacterial susceptibilities AK Watson, B Kepplinger, SM Bakhiet, NA Mhmoud, J Chapman, ... PLOS Neglected Tropical Diseases 16 (7), e0010128, 2022 | 4 | 2022 |
Mirubactin C rescues the lethal effect of cell wall biosynthesis mutations in Bacillus subtilis B Kepplinger, X Wen, AR Tyler, BY Kim, J Brown, P Banks, Y Dashti, ... Frontiers in Microbiology 13, 1004737, 2022 | 3 | 2022 |
Discovery, isolation, heterologous expression and mode-of-action studies of the antibiotic polyketide tatiomicin from Amycolatopsis sp. DEM30355 B Kepplinger, L Mardiana, J Cowell, S Morton-Laing, Y Dashti, C Wills, ... Scientific reports 12 (1), 15579, 2022 | 3 | 2022 |
On the mechanisms of lysis triggered by perturbations of bacterial cell wall biosynthesis Y Kawai, M Kawai, ES Mackenzie, Y Dashti, B Kepplinger, KJ Waldron, ... Nature Communications 14 (1), 4123, 2023 | 1 | 2023 |
The Discovery and Characterisation of Novel Antibiotics from Amycolatopsis Isolate DEM30355 B Kepplinger Newcastle University, 2016 | 1 | 2016 |
The interplay between the polar growth determinant DivIVA, the segregation protein ParA, and their novel interaction partner PapM controls the Mycobacterium smegmatis cell … I Matusiak, A Strzałka, P Wadach, M Gongerowska-Jac, E Szwajczak, ... Microbiology Spectrum 11 (6), e01752-23, 2023 | | 2023 |
Discovery of the Antibiotic Polyketide Tatiomicin via a Genomics Guided Analysis of Amycolatopsis sp. DEM30355 B Kepplinger, J Cowell, S Morton-Laing, C Wills, E Marrs, J Perry, J Grey, ... | | 2020 |
Compounds for Treating Infections Caused by Rifampicin-resistant Bacteria B Kepplinger, H Sejzi, N Zenkin, M Hall, N Allenby, J Errington Newcastle University, 2018 | | 2018 |