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Joleen Masschelein
Joleen Masschelein
Assistant Professor at KU Leuven & Group Leader at Flanders Institute for Biotechnology (VIB)
Verified email at kuleuven.be - Homepage
Title
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Cited by
Year
Minimum information about a biosynthetic gene cluster
MH Medema, R Kottmann, P Yilmaz, M Cummings, JB Biggins, K Blin, ...
Nature chemical biology 11 (9), 625-631, 2015
8332015
Antibiotics from Gram-negative bacteria: a comprehensive overview and selected biosynthetic highlights
J Masschelein, M Jenner, GL Challis
Natural product reports 34 (7), 712-783, 2017
1142017
Isolation and purification of a new kalimantacin/batumin-related polyketide antibiotic and elucidation of its biosynthesis gene cluster
W Mattheus, LJ Gao, P Herdewijn, B Landuyt, J Verhaegen, ...
Chemistry & biology 17 (2), 149-159, 2010
992010
Discovery and Biosynthesis of Gladiolin: A Burkholderia gladioli Antibiotic with Promising Activity against Mycobacterium tuberculosis
L Song, M Jenner, J Masschelein, C Jones, MJ Bull, SR Harris, ...
Journal of the American Chemical Society 139 (23), 7974-7981, 2017
942017
A PKS/NRPS/FAS hybrid gene cluster from Serratia plymuthica RVH1 encoding the biosynthesis of three broad spectrum, zeamine-related antibiotics
J Masschelein, W Mattheus, LJ Gao, P Moons, R Van Houdt, ...
PLoS One 8 (1), e54143, 2013
882013
A conserved motif flags acyl carrier proteins for β-branching in polyketide synthesis
AS Haines, X Dong, Z Song, R Farmer, C Williams, J Hothersall, ...
Nature chemical biology 9 (11), 685-692, 2013
742013
Thioester reduction and aldehyde transamination are universal steps in actinobacterial polyketide alkaloid biosynthesis
GLC Ufedo R. Awodi1, Jade L. Ronan1, Joleen Masschelein1, Emmanuel L.C. de ...
Chemical Science, 2016
52*2016
Structural basis for chain release from the enacyloxin polyketide synthase
S Kosol, A Gallo, D Griffiths, TR Valentic, J Masschelein, M Jenner, ...
Nature chemistry 11 (10), 913-923, 2019
432019
The kalimantacin/batumin biosynthesis operon encodes a self-resistance isoform of the FabI bacterial target
W Mattheus, J Masschelein, LJ Gao, P Herdewijn, B Landuyt, G Volckaert, ...
Chemistry & biology 17 (10), 1067-1071, 2010
422010
Beyond peptide bond formation: the versatile role of condensation domains in natural product biosynthesis
S Dekimpe, J Masschelein
Natural product reports 38 (10), 1910-1937, 2021
402021
An unusual Burkholderia gladioli double chain-initiating nonribosomal peptide synthetase assembles ‘fungal’ icosalide antibiotics
M Jenner, X Jian, Y Dashti, J Masschelein, C Hobson, D Roberts, C Jones, ...
Chemical Science 10 (DOI: 10.1039/C8SC04897E), 2019
402019
A combination of polyunsaturated fatty acid, nonribosomal peptide and polyketide biosynthetic machinery is used to assemble the zeamine antibiotics
J Masschelein, C Clauwers, UR Awodi, K Stalmans, W Vermaelen, ...
Chemical science 6 (2), 923-929, 2015
362015
The zeamine antibiotics affect the integrity of bacterial membranes
J Masschelein, C Clauwers, K Stalmans, K Nuyts, W De Borggraeve, ...
Applied and environmental microbiology 81 (3), 1139-1146, 2015
352015
A dual transacylation mechanism for polyketide synthase chain release in enacyloxin antibiotic biosynthesis
J Masschelein, PK Sydor, C Hobson, R Howe, C Jones, DM Roberts, ...
Nature chemistry 11 (10), 906-912, 2019
312019
Artificial intelligence for natural product drug discovery
MW Mullowney, KR Duncan, SS Elsayed, N Garg, JJJ van der Hooft, ...
Nature Reviews Drug Discovery 22 (11), 895-916, 2023
282023
The Kalimantacin Polyketide Antibiotics Inhibit Fatty Acid Biosynthesis in Staphylococcus aureus by Targeting the Enoyl‐Acyl Carrier Protein Binding Site of FabI
CD Fage, T Lathouwers, M Vanmeert, LJ Gao, K Vrancken, EM Lammens, ...
Angewandte Chemie International Edition 59 (26), 10549-10556, 2020
262020
Pentamycin Biosynthesis in Philippine Streptomyces sp. S816: Cytochrome P450-Catalyzed Installation of the C-14 Hydroxyl Group
S Zhou, L Song, J Masschelein, FAM Sumang, IA Papa, TO Zulaybar, ...
ACS Chemical Biology 14 (6), 1305-1309, 2019
212019
Elucidation of the relative and absolute stereochemistry of the kalimantacin/batumin antibiotics
IRG Thistlethwaite, FM Bull, C Cui, PD Walker, SS Gao, L Wang, Z Song, ...
Chemical Science 8 (9), 6196-6201, 2017
202017
Genomics‐Driven Discovery of a Novel Glutarimide Antibiotic from Burkholderia gladioli Reveals an Unusual Polyketide Synthase Chain Release Mechanism
IT Nakou, M Jenner, Y Dashti, I Romero‐Canelón, J Masschelein, ...
Angewandte Chemie 132 (51), 23345-23353, 2020
192020
Genome sequence of Serratia plymuthica RVH1, isolated from a raw vegetable-processing line
R Van Houdt, D Van der Lelie, JA Izquierdo, A Aertsen, J Masschelein, ...
Genome announcements 2 (1), 10.1128/genomea. 00021-14, 2014
102014
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