Nathan Robertson
Nathan Robertson
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Structure of the adenosine A2A receptor in complex with ZM241385 and the xanthines XAC and caffeine
AS Doré, N Robertson, JC Errey, I Ng, K Hollenstein, B Tehan, E Hurrell, ...
Structure 19 (9), 1283-1293, 2011
Structures of human A1 and A2A adenosine receptors with xanthines reveal determinants of selectivity
RKY Cheng, E Segala, N Robertson, F Deflorian, AS Doré, JC Errey, ...
Structure 25 (8), 1275-1285. e4, 2017
Extra-helical binding site of a glucagon receptor antagonist
A Jazayeri, AS Doré, D Lamb, H Krishnamurthy, SM Southall, AH Baig, ...
Nature 533 (7602), 274-277, 2016
Crystal structure of the GLP-1 receptor bound to a peptide agonist
A Jazayeri, M Rappas, AJH Brown, J Kean, JC Errey, NJ Robertson, ...
Nature 546 (7657), 254-258, 2017
The properties of thermostabilised G protein-coupled receptors (StaRs) and their use in drug discovery
N Robertson, A Jazayeri, J Errey, A Baig, E Hurrell, A Zhukov, ...
Neuropharmacology 60 (1), 36-44, 2011
Identification of Novel Adenosine A2A Receptor Antagonists by Virtual Screening
CJ Langmead, SP Andrews, M Congreve, JC Errey, E Hurrell, ...
Journal of medicinal chemistry 55 (5), 1904-1909, 2012
Biophysical Mapping of the Adenosine A2A Receptor
A Zhukov, SP Andrews, JC Errey, N Robertson, B Tehan, JS Mason, ...
Journal of medicinal chemistry 54 (13), 4312-4323, 2011
Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727
N Robertson, M Rappas, AS Doré, J Brown, G Bottegoni, M Koglin, ...
Nature 553 (7686), 111-114, 2018
How do short chain nonionic detergents destabilize G-protein-coupled receptors?
S Lee, A Mao, S Bhattacharya, N Robertson, R Grisshammer, CG Tate, ...
Journal of the American Chemical Society 138 (47), 15425-15433, 2016
From structure to clinic: Design of a muscarinic M1 receptor agonist with the potential to treat Alzheimer’s disease
AJH Brown, SJ Bradley, FH Marshall, GA Brown, KA Bennett, J Brown, ...
Cell 184 (24), 5886-5901. e22, 2021
How do branched detergents stabilize GPCRs in micelles?
S Lee, S Ghosh, S Jana, N Robertson, CG Tate, N Vaidehi
Biochemistry 59 (23), 2125-2134, 2020
Mutant proteins and methods for producing them
SA Jazayeri-Dezfuly, GP Lebon, FH Marshall, CG Tate, N Robertson
US Patent 8,703,915, 2014
Development of a novel mammalian display system for selection of antibodies against membrane proteins
N Robertson, N Lopez-Anton, SA Gurjar, H Khalique, Z Khalaf, S Clerkin, ...
Journal of Biological Chemistry 295 (52), 18436-18448, 2020
Mutant g-protein coupled receptor proteins and methods for producing them
NJ Robertson, FH Marshall
US Patent App. 13/980,497, 2014
The role of ICL1 and H8 in class B1 GPCRs; implications for receptor activation
I Winfield, K Barkan, S Routledge, NJ Robertson, M Harris, A Jazayeri, ...
Frontiers in Endocrinology 12, 792912, 2022
Mutant g-protein coupled receptor proteins and methods for producing them
NJ Robertson, FH Marshall
US Patent App. 15/197,575, 2017
Antibody agonists trigger immune receptor signaling through local exclusion of receptor-type protein tyrosine phosphatases
AH Lippert, C Paluch, M Gaglioni, MT Vuong, J McColl, E Jenkins, ...
Immunity 57 (2), 256-270. e10, 2024
Large scale expression and purification of the rat 5-HT2c receptor
X He, N Robertson, A Jazayeri, AG Gasperina, G Schertler, X Li
Protein expression and purification 106, 1-9, 2015
Applications and challenges in designing VHH-based bispecific antibodies: leveraging machine learning solutions
M Mullin, J McClory, W Haynes, J Grace, N Robertson, G van Heeke
Mabs 16 (1), 2341443, 2024
Engineered cd200r antibodies and uses thereof
SJ Davis, RJ Cornall, CD Paluch, LA Murray, NJ Robertson, EM Scott, ...
US Patent App. 18/296,296, 2023
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