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Lena Ripa
Lena Ripa
RIA iMed, AstraZeneca
Verified email at astrazeneca.com
Title
Cited by
Cited by
Year
Intramolecular enantioselective palladium-catalyzed Heck arylation of cyclic enamides
L Ripa, A Hallberg
The Journal of Organic Chemistry 62 (3), 595-602, 1997
1281997
Controlled double-bond migration in palladium-catalyzed intramolecular arylation of enamidines
L Ripa, A Hallberg
The Journal of Organic Chemistry 61 (20), 7147-7155, 1996
781996
Explanation for main features of structure–genotoxicity relationships of aromatic amines by theoretical studies of their activation pathways in CYP1A2
I Shamovsky, L Ripa, L Borjesson, C Mee, B Nordén, P Hansen, ...
Journal of the American Chemical Society 133 (40), 16168-16185, 2011
752011
Discovery of a novel oral glucocorticoid receptor modulator (AZD9567) with improved side effect profile
L Ripa, K Edman, M Dearman, G Edenro, R Hendrickx, V Ullah, ...
Journal of Medicinal Chemistry 61 (5), 1785-1799, 2018
662018
Synthesis of two conformationally constrained analogues of the minor tobacco alkaloid anabasine
S Lindström, L Ripa, A Hallberg
Organic Letters 2 (15), 2291-2293, 2000
622000
Increasing selectivity of CC chemokine receptor 8 antagonists by engineering nondesolvation related interactions with the intended and off-target binding sites
I Shamovsky, C de Graaf, L Alderin, M Bengtsson, H Bladh, L Börjesson, ...
Journal of medicinal chemistry 52 (23), 7706-7723, 2009
372009
Theoretical studies of chemical reactivity of metabolically activated forms of aromatic amines toward DNA
I Shamovsky, L Ripa, N Blomberg, LA Eriksson, P Hansen, C Mee, ...
Chemical Research in Toxicology 25 (10), 2236-2252, 2012
352012
Aryl Radical Endo Cyclization of Enamidines. Selective Preparation of Trans and Cis Fused Octahydrobenzo[f]quinolines
L Ripa, A Hallberg
The Journal of Organic Chemistry 63 (1), 84-91, 1998
321998
Theoretical studies of the mechanism of N-hydroxylation of primary aromatic amines by cytochrome P450 1A2: radicaloid or anionic?
L Ripa, C Mee, P Sjo, I Shamovsky
Chemical Research in Toxicology 27 (2), 265-278, 2014
212014
Determination of Absolute Configurations of N-Formyl-3, 3 ‘, 4, 4 ‘-tetrahydrospiro [naphthalene-1 (2 H), 2 ‘(1 ‘H)-pyridine](2) and N-Formyl-3 ‘, 4 ‘-dihydrospiro [indan-1, 2 …
L Ripa, A Hallberg, J Sandström
Journal of the American Chemical Society 119 (24), 5701-5705, 1997
201997
Discovery of the Oral Leukotriene C4 Synthase Inhibitor (1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-fluoro-2-methylpropyl)amino]-3-methoxypyrazin-2-yl …
M Munck af Rosenschöld, P Johannesson, A Nikitidis, C Tyrchan, ...
Journal of Medicinal Chemistry 62 (17), 7769-7787, 2019
172019
Compounds
B Gabos, L Ripa, K Stenvall
US Patent App. 11/571,643, 2008
152008
A phenotypic screening approach using human treg cells identified regulators of forkhead Box p3 expression
M Ding, J Brengdahl, M Lindqvist, U Gehrmann, E Ericson, S von Berg, ...
ACS Chemical Biology 14 (3), 543-553, 2019
132019
Hydantoin derivatives for the treatment of obstructive airway diseases
B Gabos, L Ripa, K Stenvall
US Patent 7,648,992, 2010
132010
Fragment-based discovery of novel allosteric MEK1 binders
P Di Fruscia, F Edfeldt, I Shamovsky, GW Collie, A Aagaard, L Barlind, ...
ACS Medicinal Chemistry Letters 12 (2), 302-308, 2021
102021
Mechanism-based insights into removing the mutagenicity of aromatic amines by small structural alterations
I Shamovsky, L Ripa, F Narjes, B Bonn, S Schiesser, I Terstiege, ...
Journal of Medicinal Chemistry 64 (12), 8545-8563, 2021
92021
HDAC6 inhibitor ACY-1083 shows lung epithelial protective features in COPD
J Horndahl, R Svärd, P Berntsson, C Wingren, J Li, SM Abdillahi, B Ghosh, ...
PloS one 17 (10), e0266310, 2022
72022
Theoretical studies of the second step of the nitric oxide synthase reaction: Electron tunneling prevents uncoupling
I Shamovsky, G Belfield, R Lewis, F Narjes, L Ripa, C Tyrchan, L Öberg, ...
Journal of Inorganic Biochemistry 181, 28-40, 2018
72018
Hydantoin derivatives for the treatment of obstructive airway diseases
B Gabos, L Ripa, K Stenvall
US Patent 7,989,620, 2011
52011
Hydantoin derivatives for the treatment of obstructive airway diseases
B Gabos, L Ripa, K Stenvall
US Patent 7,989,620, 2011
52011
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