| SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist SN Haydar, C Ghiron, L Bettinetti, H Bothmann, TA Comery, J Dunlop, ... Bioorganic & medicinal chemistry 17 (14), 5247-5258, 2009 | 66 | 2009 |
| Creating a data resource: what will it take to build a medical information commons? PA Deverka, MA Majumder, AG Villanueva, M Anderson, AC Bakker, ... Genome Medicine 9, 1-5, 2017 | 51 | 2017 |
| Cutaneous neurofibromas in the genomics era: current understanding and open questions RJ Allaway, SJC Gosline, S La Rosa, P Knight, A Bakker, J Guinney, ... British journal of cancer 118 (12), 1539-1548, 2018 | 49 | 2018 |
| The synthesis of 7-deazaguanines as potential inhibitors of guanosine triphosphate cyclohydrolase I CL Gibson, S La Rosa, K Ohta, PH Boyle, F Leurquin, A Lemaçon, ... Tetrahedron 60 (4), 943-959, 2004 | 45 | 2004 |
| Novel alpha-7 nicotinic acetylcholine receptor agonists containing a urea moiety: identification and characterization of the potent, selective, and orally efficacious agonist 1 … C Ghiron, SN Haydar, S Aschmies, H Bothmann, C Castaldo, ... Journal of medicinal chemistry 53 (11), 4379-4389, 2010 | 37 | 2010 |
| A prototype solid phase synthesis of pteridines and related heterocyclic compounds CL Gibson, S La Rosa, CJ Suckling Organic & biomolecular chemistry 1 (11), 1909-1918, 2003 | 31 | 2003 |
| A high-throughput molecular data resource for cutaneous neurofibromas SJC Gosline, H Weinberg, P Knight, T Yu, X Guo, N Prasad, A Jones, ... Scientific data 4 (1), 1-9, 2017 | 26 | 2017 |
| Brigatinib causes tumor shrinkage in both NF2-deficient meningioma and schwannoma through inhibition of multiple tyrosine kinases but not ALK LS Chang, JL Oblinger, AE Smith, M Ferrer, SP Angus, E Hawley, ... PLoS One 16 (7), e0252048, 2021 | 25 | 2021 |
| A traceless solid-phase synthesis of pteridines CL Gibson, S La Rosa, CJ Suckling Tetrahedron letters 44 (6), 1267-1270, 2003 | 24 | 2003 |
| Traditional and systems biology based drug discovery for the rare tumor syndrome neurofibromatosis type 2 Synodos for NF2 Consortium, R Allaway, SP Angus, RL Beauchamp, ... PLoS One 13 (6), e0197350, 2018 | 22 | 2018 |
| Novel hits in the correction of ΔF508-cystic fibrosis transmembrane conductance regulator (CFTR) protein: synthesis, pharmacological, and ADME evaluation of tetrahydropyrido [4 … E Pesci, L Bettinetti, P Fanti, LJV Galietta, S La Rosa, L Magnoni, ... Journal of Medicinal Chemistry 58 (24), 9697-9711, 2015 | 17 | 2015 |
| Neurofibromatosis as a gateway to better treatment for a variety of malignancies AC Bakker, S La Rosa, LS Sherman, P Knight, H Lee, P Pancza, M Nievo Progress in neurobiology 152, 149-165, 2017 | 15 | 2017 |
| Recombinant Adeno Associated Viral (AAV) vector type 9 delivery of Ex1-Q138-mutant huntingtin in the rat striatum as a short-time model for in vivo studies in drug discovery I Ceccarelli, P Fiengo, R Remelli, V Miragliotta, L Rossini, I Biotti, ... Neurobiology of disease 86, 41-51, 2016 | 12 | 2016 |
| Fused 3-hydroxy-3-trifluoromethylpyrazoles inhibit mutant huntingtin toxicity S La Rosa, T Benicchi, L Bettinetti, I Ceccarelli, E Diodato, C Federico, ... ACS medicinal chemistry letters 4 (10), 979-984, 2013 | 12 | 2013 |
| Probing the chemical–biological relationship space with the Drug Target Explorer RJ Allaway, S La Rosa, J Guinney, SJC Gosline Journal of Cheminformatics 10, 1-14, 2018 | 11 | 2018 |
| Drug discovery and development for Huntington’s disease-an orphan indication with high medical need F Heitz, S La Rosa, E Gonzalez-Couto, G Gaviraghi, GC Terstappen IDrugs 11 (9), 653-660, 2008 | 11 | 2008 |
| Engaging a community to enable disease-centric data sharing with the NF Data Portal RJ Allaway, S La Rosa, S Verma, L Mangravite, J Guinney, J Blakeley, ... Scientific data 6 (1), 319, 2019 | 9 | 2019 |
| A phenotypic screening assay for modulators of Huntingtin-induced transcriptional dysregulation G Lazzeroni, T Benicchi, F Heitz, L Magnoni, D Diamanti, L Rossini, ... Journal of Biomolecular Screening 18 (9), 984-996, 2013 | 9 | 2013 |
| Synthesis of 3‐imidazolylazole derivatives from a new nitrile oxide F Foti, G Grassi, F Risitano, S La Rosa Journal of Heterocyclic Chemistry 38 (2), 539-540, 2001 | 6 | 2001 |
| Rethinking the nonprofit foundation: an emerging niche in the rare disease ecosystem AC Bakker, S La Rosa EMBO Molecular Medicine 9 (9), 1179-1182, 2017 | 4 | 2017 |
