John D Hayes
John D Hayes
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The glut athione S-transferase supergene family: regulation of GST and the contribution of the lsoenzymes to cancer chemoprotection and drug resistance part I
JD Hayes, DJ Pulford
Critical reviews in biochemistry and molecular biology 30 (6), 445-520, 1995
Glutathione transferases
JD Hayes, JU Flanagan, IR Jowsey
Annu. Rev. Pharmacol. Toxicol. 45, 51-88, 2005
Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress
JD Hayes, LI McLellan
Free radical research 31 (4), 273-300, 1999
The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
JD Hayes, AT Dinkova-Kostova
Trends in biochemical sciences 39 (4), 199-218, 2014
p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription
A Jain, T Lamark, E Sjøttem, KB Larsen, JA Awuh, A Øvervatn, ...
Journal of biological chemistry 285 (29), 22576-22591, 2010
Glutathione S-transferase polymorphisms and their biological consequences
JD Hayes, RC Strange
Pharmacology 61 (3), 154-166, 2000
Oxidative stress in cancer
JD Hayes, AT Dinkova-Kostova, KD Tew
Cancer cell 38 (2), 167-197, 2020
Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression
M McMahon, K Itoh, M Yamamoto, JD Hayes
Journal of Biological Chemistry 278 (24), 21592-21600, 2003
NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer
JD Hayes, M McMahon
Trends in biochemical sciences 34 (4), 176-188, 2009
Nomenclature for human glutathione transferases.
B Mannervik, YC Awasthi, PG Board, JD Hayes, C Di Ilio, B Ketterer, ...
Biochemical Journal 282 (Pt 1), 305, 1992
Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases
A Cuadrado, AI Rojo, G Wells, JD Hayes, SP Cousin, WL Rumsey, ...
Nature reviews Drug discovery 18 (4), 295-317, 2019
The Cap ‘n’Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification …
M McMahon, K Itoh, M Yamamoto, SA Chanas, CJ Henderson, ...
Cancer research 61 (8), 3299-3307, 2001
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease
LE Tebay, H Robertson, ST Durant, SR Vitale, TM Penning, ...
Free Radical Biology and Medicine 88, 108-146, 2015
SCF/β-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner
P Rada, AI Rojo, S Chowdhry, M McMahon, JD Hayes, A Cuadrado
Molecular and cellular biology 31 (6), 1121-1133, 2011
Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines
C Bonnesen, IM Eggleston, JD Hayes
Cancer research 61 (16), 6120-6130, 2001
Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity
S Chowdhry, Y Zhang, M McMahon, C Sutherland, A Cuadrado, ...
Oncogene 32 (32), 3765-3781, 2013
Cancer chemoprevention mechanisms mediated through the Keap1–Nrf2 pathway
JD Hayes, M McMahon, S Chowdhry, AT Dinkova-Kostova
Antioxidants & redox signaling 13 (11), 1713-1748, 2010
Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD (P) H: quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence
P Nioi, M McMahon, K Itoh, M Yamamoto, JD Hayes
Biochemical Journal 374 (2), 337-348, 2003
Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a “tethering” mechanism: a two-site interaction model for the Nrf2-Keap1 complex
M McMahon, N Thomas, K Itoh, M Yamamoto, JD Hayes
Journal of Biological Chemistry 281 (34), 24756-24768, 2006
Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and …
SA Chanas, Q Jiang, M McMahon, GK McWalter, LI McLellan, ...
Biochemical Journal 365 (2), 405-416, 2002
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