Ewan J McGhee
Ewan J McGhee
Beatson Institute for Cancer Research
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Actomyosin-mediated cellular tension drives increased tissue stiffness and β-catenin activation to induce epidermal hyperplasia and tumor growth
MS Samuel, JI Lopez, EJ McGhee, DR Croft, D Strachan, P Timpson, ...
Cancer cell 19 (6), 776-791, 2011
ROS production and NF-κB activation triggered by RAC1 facilitate WNT-driven intestinal stem cell proliferation and colorectal cancer initiation
KB Myant, P Cammareri, EJ McGhee, RA Ridgway, DJ Huels, JB Cordero, ...
Cell stem cell 12 (6), 761-773, 2013
Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy
BW Miller, JP Morton, M Pinese, G Saturno, NB Jamieson, E McGhee, ...
EMBO molecular medicine 7 (8), 1063-1076, 2015
Talin tension sensor reveals novel features of focal adhesion force transmission and mechanosensitivity
A Kumar, M Ouyang, K Van den Dries, EJ McGhee, K Tanaka, ...
Journal of Cell Biology 213 (3), 371-383, 2016
Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis
C Vennin, VT Chin, SC Warren, MC Lucas, D Herrmann, A Magenau, ...
Science translational medicine 9 (384), eaai8504, 2017
Hybridization of electronic states in quantum dots through photon emission
K Karrai, RJ Warburton, C Schulhauser, A H÷gele, B Urbaszek, ...
Nature 427 (6970), 135-138, 2004
Spatial Regulation of RhoA Activity during Pancreatic Cancer Cell Invasion Driven by Mutant p53RhoA Activity In Vivo
P Timpson, EJ McGhee, JP Morton, A Von Kriegsheim, JP Schwarz, ...
Cancer research 71 (3), 747-757, 2011
High mammographic density is associated with an increase in stromal collagen and immune cells within the mammary epithelium
CW Huo, G Chew, P Hill, D Huang, W Ingman, L Hodson, KA Brown, ...
Breast Cancer Research 17 (1), 1-20, 2015
Tumor matrix stiffness promotes metastatic cancer cell interaction with the endothelium
SE Reid, EJ Kay, LJ Neilson, AT Henze, J Serneels, EJ McGhee, ...
The EMBO journal 36 (16), 2373-2389, 2017
CSF1R+ Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype
JB Candido, JP Morton, P Bailey, AD Campbell, SA Karim, T Jamieson, ...
Cell reports 23 (5), 1448-1460, 2018
Multiplexed FRET to image multiple signaling events in live cells
DM Grant, W Zhang, EJ McGhee, TD Bunney, CB Talbot, S Kumar, ...
Biophysical journal 95 (10), L69-L71, 2008
Intravital FLIM-FRET Imaging Reveals Dasatinib-Induced Spatial Control of Src in Pancreatic CancerImaging Drug Targeting in Live Tumors
M Nobis, EJ McGhee, JP Morton, JP Schwarz, SA Karim, J Quinn, ...
Cancer research 73 (15), 4674-4686, 2013
Luminal Iron Levels Govern Intestinal Tumorigenesis after Apc Loss InáVivo
S Radulescu, MJ Brookes, P Salgueiro, RA Ridgway, E McGhee, ...
Cell reports 2 (2), 270-282, 2012
Organotypic collagen I assay: a malleable platform to assess cell behaviour in a 3-dimensional context
P Timpson, EJ Mcghee, Z Erami, M Nobis, JA Quinn, M Edward, ...
JoVE (Journal of Visualized Experiments), e3089, 2011
ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth
N Rath, JP Morton, L Julian, L Helbig, S Kadir, EJ McGhee, KI Anderson, ...
EMBO molecular medicine 9 (2), 198-218, 2017
High speed optically sectioned fluorescence lifetime imaging permits study of live cell signaling events
DM Grant, J McGinty, EJ McGhee, TD Bunney, DM Owen, CB Talbot, ...
Optics express 15 (24), 15656-15673, 2007
The Rac-FRET mouse reveals tight spatiotemporal control of Rac activity in primary cells and tissues
AKE Johnsson, Y Dai, M Nobis, MJ Baker, EJ McGhee, S Walker, ...
Cell reports 6 (6), 1153-1164, 2014
A RhoA-FRET biosensor mouse for intravital imaging in normal tissue homeostasis and disease contexts
M Nobis, D Herrmann, SC Warren, S Kadir, W Leung, M Killen, ...
Cell reports 21 (1), 274-288, 2017
Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels
D Novo, N Heath, L Mitchell, G Caligiuri, A MacFarlane, D Reijmer, ...
Nature communications 9 (1), 1-17, 2018
Imaging molecular dynamics in vivo–from cell biology to animal models
P Timpson, EJ McGhee, KI Anderson
Journal of cell science 124 (17), 2877-2890, 2011
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