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Attila Lehotzky
Attila Lehotzky
Institute of Enzymology, HUN-RES
Verified email at ttk.hu
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Cited by
Year
Chemically induced degradation of sirtuin 2 (Sirt2) by a proteolysis targeting chimera (PROTAC) based on sirtuin rearranging ligands (SirReals)
M Schiedel, D Herp, S Hammelmann, S Swyter, A Lehotzky, D Robaa, ...
Journal of medicinal chemistry 61 (2), 482-491, 2018
2662018
Selective Sirt2 inhibition by ligand-induced rearrangement of the active site
T Rumpf, M Schiedel, B Karaman, C Roessler, BJ North, A Lehotzky, ...
Nature communications 6 (1), 6263, 2015
2622015
Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies
GG Kovács, L László, J Kovács, PH Jensen, E Lindersson, G Botond, ...
Neurobiology of disease 17 (2), 155-162, 2004
1662004
Tubulin polymerization‐promoting protein (TPPP/p25) is critical for oligodendrocyte differentiation
A Lehotzky, P Lau, N Tőkési, N Muja, LD Hudson, J Ovádi
Glia 58 (2), 157-168, 2010
1362010
TPPP/p25 promotes tubulin acetylation by inhibiting histone deacetylase 6
N Tőkési, A Lehotzky, I Horváth, B Szabó, J Oláh, P Lau, J Ovádi
Journal of Biological Chemistry 285 (23), 17896-17906, 2010
1152010
Interaction of phosphofructokinase with tubulin and microtubules. Quantitative evaluation of the mutual effects
A Lehotzky, M Telegdi, K Liliom, J Ovadi
Journal of Biological Chemistry 268 (15), 10888-10894, 1993
1061993
Tubulin polymerization promoting proteins (TPPPs): members of a new family with distinct structures and functions
O Vincze, N Tökési, J Oláh, E Hlavanda, Á Zotter, I Horváth, A Lehotzky, ...
Biochemistry 45 (46), 13818-13826, 2006
942006
Aminothiazoles as potent and selective Sirt2 inhibitors: a structure–activity relationship study
M Schiedel, T Rumpf, B Karaman, A Lehotzky, J Oláh, S Gerhardt, J Ovádi, ...
Journal of medicinal chemistry 59 (4), 1599-1612, 2016
862016
Dynamic targeting of microtubules by TPPP/p25 affects cell survival
A Lehotzky, L Tirián, N Tokesi, P Lénárt, B Szabó, J Kovács, J Ovádi
Journal of cell science 117 (25), 6249-6259, 2004
852004
The brain-specific protein TPPP/p25 in pathological protein deposits of neurodegenerative diseases
GG Kovács, E Gelpi, A Lehotzky, R Höftberger, A Erdei, H Budka, J Ovádi
Acta Neuropathologica 113, 153-161, 2007
722007
TPPP/p25: from unfolded protein to misfolding disease: prediction and experiments
F Orosz, GG Kovács, A Lehotzky, J Oláh, O Vincze, J Ovádi
Biology of the Cell 96 (9), 701-711, 2004
682004
Structure‐Based Development of an Affinity Probe for Sirtuin 2
M Schiedel, T Rumpf, B Karaman, A Lehotzky, S Gerhardt, J Ovádi, ...
Angewandte Chemie International Edition 55 (6), 2252-2256, 2016
612016
Interaction of TPPP/p25 protein with glyceraldehyde‐3‐phosphate dehydrogenase and their co‐localization in Lewy bodies
J Oláh, N Tőkési, O Vincze, I Horváth, A Lehotzky, A Erdei, E Szájli, ...
FEBS letters 580 (25), 5807-5814, 2006
422006
Pyruvate Kinase as a Microtubule Destabilizing Factorin Vitro
BG Vértessy, D Bánkfalvi, J Kovács, P Löw, A Lehotzky, J Ovádi
Biochemical and biophysical research communications 254 (2), 430-435, 1999
391999
Characterization of microtubule− phosphofructokinase complex: specific effects of MgATP and vinblastine
BG Vértessy, J Kovács, P Löw, A Lehotzky, A Molnár, F Orosz, J Ovádi
Biochemistry 36 (8), 2051-2062, 1997
351997
TPPP/p25 in brain tumours: expression in non-neoplastic oligodendrocytes but not in oligodendroglioma cells
M Preusser, A Lehotzky, H Budka, J Ovádi, GG Kovács
Acta neuropathologica 113, 213-215, 2007
342007
Microtubule-associated proteins with regulatory functions by day and pathological potency at night
J Oláh, A Lehotzky, S Szunyogh, T Szénási, F Orosz, J Ovádi
Cells 9 (2), 357, 2020
312020
Ligand-modulated cross-bridging of microtubules by phosphofructokinase
A Lehotzky, Z Palfia, J Kovacs, A Molnar, J Ovadi
Biochemical and biophysical research communications 204 (2), 585-591, 1994
311994
New chemical tools for probing activity and inhibition of the NAD+-dependent lysine deacylase sirtuin 2
S Swyter, M Schiedel, D Monaldi, S Szunyogh, A Lehotzky, T Rumpf, ...
Philosophical Transactions of the Royal Society B: Biological Sciences 373 …, 2018
292018
Challenging drug target for Parkinson's disease: Pathological complex of the chameleon TPPP/p25 and alpha-synuclein proteins
T Szénási, J Oláh, A Szabó, S Szunyogh, A Láng, A Perczel, A Lehotzky, ...
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1863 (1), 310-323, 2017
282017
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