Konstantinos Tzelepis
Konstantinos Tzelepis
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Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control
I Barbieri, K Tzelepis, L Pandolfini, J Shi, G Millán-Zambrano, SC Robson, ...
Nature 552 (7683), 126-131, 2017
A CRISPR dropout screen identifies genetic vulnerabilities and therapeutic targets in acute myeloid leukemia
K Tzelepis, H Koike-Yusa, E De Braekeleer, Y Li, E Metzakopian, ...
Cell reports 17 (4), 1193-1205, 2016
Small-molecule inhibition of METTL3 as a strategy against myeloid leukaemia
E Yankova, W Blackaby, M Albertella, J Rak, E De Braekeleer, ...
Nature 593 (7860), 597-601, 2021
RNA modifications detection by comparative Nanopore direct RNA sequencing
A Leger, PP Amaral, L Pandolfini, C Capitanchik, F Capraro, V Miano, ...
Nature communications 12 (1), 7198, 2021
METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation
EA Orellana, Q Liu, E Yankova, M Pirouz, E De Braekeleer, W Zhang, ...
Molecular cell 81 (16), 3323-3338. e14, 2021
Glutaminolysis is a metabolic dependency in FLT3ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition
P Gallipoli, G Giotopoulos, K Tzelepis, ASH Costa, S Vohra, ...
Blood, The Journal of the American Society of Hematology 131 (15), 1639-1653, 2018
Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia without ring sideroblasts
A Mupo, M Seiler, V Sathiaseelan, A Pance, Y Yang, AA Agrawal, F Iorio, ...
Leukemia 31 (3), 720-727, 2017
UTX-mediated enhancer and chromatin remodeling suppresses myeloid leukemogenesis through noncatalytic inverse regulation of ETS and GATA programs
M Gozdecka, E Meduri, M Mazan, K Tzelepis, M Dudek, AJ Knights, ...
Nature genetics 50 (6), 883-894, 2018
Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia
OM Dovey, JL Cooper, A Mupo, CS Grove, C Lynn, N Conte, RM Andrews, ...
Blood, The Journal of the American Society of Hematology 130 (17), 1911-1922, 2017
SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4
K Tzelepis, E De Braekeleer, D Aspris, I Barbieri, MS Vijayabaskar, ...
Nature communications 9 (1), 5378, 2018
Premature activation of Cdk1 leads to mitotic events in S phase and embryonic lethality
R Szmyd, J Niska-Blakie, MK Diril, P Renck Nunes, K Tzelepis, A Lacroix, ...
Oncogene 38 (7), 998-1018, 2019
Enhancing the genome editing toolbox: genome wide CRISPR arrayed libraries
E Metzakopian, A Strong, V Iyer, A Hodgkins, K Tzelepis, L Antunes, ...
Scientific reports 7 (1), 2244, 2017
Identification of SARS-CoV-2–induced pathways reveals drug repurposing strategies
N Han, W Hwang, K Tzelepis, P Schmerer, E Yankova, M MacMahon, ...
Science Advances 7 (27), eabh3032, 2021
meCLICK-Seq, a substrate-hijacking and RNA degradation strategy for the study of RNA methylation
S Mikutis, M Gu, E Sendinc, ME Hazemi, H Kiely-Collins, D Aspris, ...
ACS central science 6 (12), 2196-2208, 2020
Cyclin D1 in invasive breast carcinoma: favourable prognostic significance in unselected patients and within subgroups with an aggressive phenotype
E Mylona, K Tzelepis, I Theohari, I Giannopoulou, C Papadimitriou, ...
Histopathology 62 (3), 472-480, 2013
KAT7 is a genetic vulnerability of acute myeloid leukemias driven by MLL rearrangements
YZ Au, M Gu, E De Braekeleer, M Gozdecka, D Aspris, Y Tarumoto, ...
Leukemia 35 (4), 1012-1022, 2021
RNA-modifying enzymes and their function in a chromatin context
K Tzelepis, O Rausch, T Kouzarides
Nature structural & molecular biology 26 (10), 858-862, 2019
Effect of BRCA1 immunohistochemical localizations on prognosis of patients with sporadic breast carcinomas
E Mylona, S Melissaris, A Nomikos, I Theohari, I Giannopoulou, ...
Pathology-Research and Practice 210 (8), 533-540, 2014
Methylation of histone H3 at lysine 37 by Set1 and Set2 prevents spurious DNA replication
H Santos-Rosa, G Millan-Zambrano, N Han, T Leonardi, M Klimontova, ...
Molecular cell 81 (13), 2793-2807. e8, 2021
Dissecting the early steps of MLL induced leukaemogenic transformation using a mouse model of AML
S Basilico, X Wang, A Kennedy, K Tzelepis, G Giotopoulos, SJ Kinston, ...
Nature Communications 11 (1), 1407, 2020
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