|Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease|
CT Guy, RD Cardiff, WJ Muller
Molecular and cellular biology 12 (3), 954-961, 1992
|Expression of the neu protooncogene in the mammary epithelium of transgenic mice induces metastatic disease|
CT Guy, MA Webster, M Schaller, TJ Parsons, RD Cardiff, WJ Muller
Proceedings of the National Academy of Sciences 89 (22), 10578-10582, 1992
|Single-step induction of mammary adenocarcinoma in transgenic mice bearing the activated c-neu oncogene|
WJ Muller, E Sinn, PK Pattengale, R Wallace, P Leder
Cell 54 (1), 105-115, 1988
|Progression to malignancy in the polyoma middle T oncoprotein mouse breast cancer model provides a reliable model for human diseases|
EY Lin, JG Jones, P Li, L Zhu, KD Whitney, WJ Muller, JW Pollard
The American journal of pathology 163 (5), 2113-2126, 2003
|Coexpression of MMTV/v-Ha-ras and MMTV/c-myc genes in transgenic mice: synergistic action of oncogenes in vivo|
E Sinn, W Muller, P Pattengale, I Tepler, R Wallace, P Leder
Cell 49 (4), 465-475, 1987
|ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation|
JY Yang, CS Zong, W Xia, H Yamaguchi, Q Ding, X Xie, JY Lang, CC Lai, ...
Nature cell biology 10 (2), 138-148, 2008
|Suppression of tumor growth and metastasis in Mgat5-deficient mice|
M Granovsky, J Fata, J Pawling, WJ Muller, R Khokha, JW Dennis
Nature medicine 6 (3), 306-312, 2000
|Elevated expression of activated forms of Neu/ErbB‐2 and ErbB‐3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer|
PM Siegel, ED Ryan, RD Cardiff, WJ Muller
The EMBO journal 18 (8), 2149-2164, 1999
|Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer|
KC Patra, Q Wang, PT Bhaskar, L Miller, Z Wang, W Wheaton, N Chandel, ...
Cancer cell 24 (2), 213-228, 2013
|β4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis|
W Guo, Y Pylayeva, A Pepe, T Yoshioka, WJ Muller, G Inghirami, ...
Cell 126 (3), 489-502, 2006
|Transforming growth factor β signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis|
PM Siegel, W Shu, RD Cardiff, WJ Muller, J Massagué
Proceedings of the National Academy of Sciences 100 (14), 8430-8435, 2003
|Targeted disruption of β1-integrin in a transgenic mouse model of human breast cancer reveals an essential role in mammary tumor induction|
DE White, NA Kurpios, D Zuo, JA Hassell, S Blaess, U Mueller, WJ Muller
Cancer cell 6 (2), 159-170, 2004
|Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation|
AM Cheng, TM Saxton, R Sakai, S Kulkarni, G Mbamalu, W Vogel, ...
Cell 95 (6), 793-803, 1998
|Cyclin D1 is required for transformation by activated Neu and is induced through an E2F-dependent signaling pathway|
RJ Lee, C Albanese, M Fu, M D'Amico, B Lin, G Watanabe, GK Haines III, ...
Molecular and cellular biology 20 (2), 672-683, 2000
|Oncogenes and tumor suppressor genes|
EYHP Lee, WJ Muller
Cold Spring Harbor perspectives in biology 2 (10), a003236, 2010
|Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases|
S Liu, M Umezu-Goto, M Murph, Y Lu, W Liu, F Zhang, S Yu, LC Stephens, ...
Cancer cell 15 (6), 539-550, 2009
|The phosphatidyl inositol 3-kinase signaling network: implications for human breast cancer|
RL Dillon, DE White, WJ Muller
Oncogene 26 (9), 1338-1345, 2007
|Caveolin-1 gene disruption promotes mammary tumorigenesis and dramatically enhances lung metastasis in vivo: role of Cav-1 in cell invasiveness and matrix metalloproteinase …|
TM Williams, F Medina, I Badano, RB Hazan, J Hutchinson, WJ Muller, ...
Journal of Biological Chemistry 279 (49), 51630-51646, 2004
|Activation of Akt (protein kinase B) in mammary epithelium provides a critical cell survival signal required for tumor progression|
J Hutchinson, J Jin, RD Cardiff, JR Woodgett, WJ Muller
Molecular and cellular biology 21 (6), 2203-2212, 2001
|Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis|
SG Julien, N Dubé, M Read, J Penney, M Paquet, Y Han, BP Kennedy, ...
Nature genetics 39 (3), 338-346, 2007