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| Structural basis of lenalidomide-induced CK1α degradation by the CRL4CRBN ubiquitin ligase G Petzold, ES Fischer, NH Thomä Nature 532 (7597), 127-130, 2016 | 487 | 2016 |
| The molecular basis of CRL4 DDB2/CSA ubiquitin ligase architecture, targeting, and activation ES Fischer, A Scrima, K Böhm, S Matsumoto, GM Lingaraju, M Faty, ... Cell 147 (5), 1024-1039, 2011 | 450 | 2011 |
| Plasticity in binding confers selectivity in ligand-induced protein degradation RP Nowak, SL DeAngelo, D Buckley, Z He, KA Donovan, J An, N Safaee, ... Nature chemical biology 14 (7), 706-714, 2018 | 440 | 2018 |
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| Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray Syndrome KA Donovan, J An, RP Nowak, JC Yuan, EC Fink, BC Berry, BL Ebert, ... Elife 7, e38430, 2018 | 347 | 2018 |
| Structure of the Human cGAS–DNA Complex Reveals Enhanced Control of Immune Surveillance W Zhou, AT Whiteley, CC de Oliveira Mann, BR Morehouse, RP Nowak, ... Cell 174 (2), 300-311. e11, 2018 | 277 | 2018 |
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| Targeted degradation of aberrant tau in frontotemporal dementia patient-derived neuronal cell models MC Silva, FM Ferguson, Q Cai, KA Donovan, G Nandi, D Patnaik, T Zhang, ... eLife 8, e45457, 2019 | 211 | 2019 |
| Exploring Targeted Degradation Strategy for Oncogenic KRASG12C M Zeng, Y Xiong, N Safaee, RP Nowak, KA Donovan, CJ Yuan, B Nabet, ... Cell Chemical Biology 27 (1), 19-31. e6, 2020 | 208 | 2020 |
| Development of dual and selective degraders of cyclin‐dependent kinases 4 and 6 B Jiang, ES Wang, KA Donovan, Y Liang, ES Fischer, T Zhang, NS Gray Angewandte Chemie International Edition 58 (19), 6321-6326, 2019 | 204 | 2019 |
| Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML M Brand, B Jiang, S Bauer, KA Donovan, Y Liang, ES Wang, RP Nowak, ... Cell chemical biology 26 (2), 300-306. e9, 2019 | 201 | 2019 |
| Cullin–RING ubiquitin E3 ligase regulation by the COP9 signalosome S Cavadini, ES Fischer, RD Bunker, A Potenza, GM Lingaraju, KN Goldie, ... Nature 531 (7596), 598-603, 2016 | 201 | 2016 |
| Chemically induced degradation of anaplastic lymphoma kinase (ALK) CE Powell, Y Gao, L Tan, KA Donovan, RP Nowak, A Loehr, M Bahcall, ... Journal of medicinal chemistry 61 (9), 4249-4255, 2018 | 181 | 2018 |
| Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development KA Donovan, FM Ferguson, JW Bushman, NA Eleuteri, D Bhunia, SS Ryu, ... Cell 183 (6), 1714-1731. e10, 2020 | 169 | 2020 |
| METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation EA Orellana, Q Liu, E Yankova, M Pirouz, E De Braekeleer, W Zhang, ... Molecular Cell 81 (16), 3323-3338. e14, 2021 | 168 | 2021 |
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| Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15 TB Faust, H Yoon, RP Nowak, KA Donovan, Z Li, Q Cai, NA Eleuteri, ... Nature chemical biology 16 (1), 7-14, 2020 | 155 | 2020 |
Michael B. StadlerHead of Computational Biology, Friedrich Miescher Institute for Biomedical Research, SwitzerlandVerified email at fmi.ch
