Dpt Cell Biology, Havard Medical School
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The BioPlex Network: A Systematic Exploration of the Human Interactome
EL Huttlin, L Ting, RJ Bruckner, F Gebreab, MP Gygi, J Szpyt, S Tam, ...
Cell 162 (2), 425-440, 2015
Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways
ET Cirulli, BN Lasseigne, S Petrovski, PC Sapp, PA Dion, CS Leblond, ...
Science 347 (6229), 1436-1441, 2015
The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy
JM Heo, A Ordureau, JA Paulo, J Rinehart, JW Harper
Molecular Cell 60 (1), 7-20, 2015
Quantitative proteomics reveal a feedforward mechanism for mitochondrial PARKIN translocation and ubiquitin chain synthesis
A Ordureau, SA Sarraf, DM Duda, JM Heo, MP Jedrychowski, ...
Molecular cell 56 (3), 360-375, 2014
14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization
RJ Nichols, N Dzamko, NA Morrice, DG Campbell, M Deak, A Ordureau, ...
Biochemical Journal 430 (3), 393-404, 2010
Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains
CH Emmerich, A Ordureau, S Strickson, JSC Arthur, PGA Pedrioli, ...
Proceedings of the National Academy of Sciences 110 (38), 15247-15252, 2013
Defining roles of PARKIN and ubiquitin phosphorylation by PINK1 in mitochondrial quality control using a ubiquitin replacement strategy
A Ordureau, JM Heo, DM Duda, JA Paulo, JL Olszewski, D Yanishevski, ...
Proceedings of the National Academy of Sciences 112 (21), 6637-6642, 2015
Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress
AM Pickrell, CH Huang, SR Kennedy, A Ordureau, DP Sideris, ...
Neuron 87 (2), 371-381, 2015
The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1
A Ordureau, H Smith, M Windheim, M Peggie, E Carrick, N Morrice, ...
Biochemical journal 409 (1), 43-52, 2008
Building and decoding ubiquitin chains for mitophagy
JW Harper, A Ordureau, JM Heo
Nature Reviews Molecular Cell Biology 19 (2), 93, 2018
Polyubiquitin binding to optineurin is required for optimal activation of TANK-binding kinase 1 and production of interferon β
CE Gleason, A Ordureau, R Gourlay, JSC Arthur, P Cohen
Journal of Biological Chemistry 286 (41), 35663-35674, 2011
Polyubiquitin binding to ABIN1 is required to prevent autoimmunity
SK Nanda, RKC Venigalla, A Ordureau, JC Patterson-Kane, DW Powell, ...
Journal of Experimental Medicine 208 (6), 1215-1228, 2011
Quantifying Ubiquitin Signaling
A Ordureau, C Münch, JW Harper
Molecular cell 58 (4), 660-676, 2015
System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes
W Zhang, KP Wu, MA Sartori, HB Kamadurai, A Ordureau, C Jiang, ...
Molecular cell 62 (1), 121-136, 2016
Cyclin C is a haploinsufficient tumor suppressor
N Li, A Fassl, J Chick, H Inuzuka, X Li, MR Mansour, L Liu, H Wang, ...
Nature cell biology 16 (11), 1080, 2014
Dual RING E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by APC/C
NG Brown, R VanderLinden, ER Watson, F Weissmann, A Ordureau, ...
Cell 165 (6), 1440-1453, 2016
Highly Multiplexed Quantitative Mass Spectrometry Analysis of Ubiquitylomes
CM Rose, M Isasa, A Ordureau, MA Prado, SA Beausoleil, ...
Cell Systems 3 (4), 395-403. e4, 2016
TRAF2 and OTUD7B govern a ubiquitin-dependent switch that regulates mTORC2 signalling
B Wang, Z Jie, D Joo, A Ordureau, P Liu, W Gan, J Guo, J Zhang, BJ North, ...
Nature 545 (7654), 365-369, 2017
G1 cyclins link proliferation, pluripotency and differentiation of embryonic stem cells
L Liu, W Michowski, H Inuzuka, K Shimizu, NT Nihira, JM Chick, N Li, ...
Nature Cell Biology 19 (3), 177-188, 2017
TEX264 is an endoplasmic reticulum-resident ATG8-interacting protein critical for ER remodeling during nutrient stress
H An, A Ordureau, JA Paulo, CJ Shoemaker, V Denic, JW Harper
Molecular cell 74 (5), 891-908. e10, 2019
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