Klaus Okkenhaug
Klaus Okkenhaug
Professor of Immunology, Department of Pathology, University of Cambridge
Verified email at cam.ac.uk - Homepage
TitleCited byYear
Requirement of bic/microRNA-155 for normal immune function
A Rodriguez, E Vigorito, S Clare, MV Warren, P Couttet, DR Soond, ...
Science 316 (5824), 608, 2007
Cellular function of phosphoinositide 3-kinases: implications for development, immunity, homeostasis, and cancer
R Katso, K Okkenhaug, K Ahmadi, S White, J Timms, MD Waterfield
Annual review of cell and developmental biology 17 (1), 615-675, 2001
Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice
K Okkenhaug, A Bilancio, G Farjot, H Priddle, S Sancho, E Peskett, ...
Science 297 (5583), 1031, 2002
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span
C Selman, J Tullet, D Wieser, E Irvine, SJ Lingard, AI Choudhury, M Claret, ...
Science 326 (5949), 140, 2009
PI3K in lymphocyte development, differentiation and activation
K Okkenhaug, B Vanhaesebroeck
Nature Reviews Immunology 3 (4), 317-330, 2003
Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation
LC Foukas, M Claret, W Pearce, K Okkenhaug, S Meek, E Peskett, ...
Nature 441 (7091), 366-370, 2006
Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice
C Selman, S Lingard, AI Choudhury, RL Batterham, M Claret, M Clements, ...
The FASEB Journal 22 (3), 807-818, 2008
Essential role for the p110δ phosphoinositide 3-kinase in the allergic response
K Ali, A Bilancio, M Thomas, W Pearce, AM Gilfillan, C Tkaczyk, N Kuehn, ...
Nature 431 (7011), 1007-1011, 2004
Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking
LV Sinclair, D Finlay, C Feijoo, GH Cornish, A Gray, A Ager, K Okkenhaug, ...
Nature immunology 9 (5), 513-521, 2008
Phosphoinositide 3-Kinase δ Gene Mutation Predisposes to Respiratory Infection and Airway Damage
I Angulo, O Vadas, F Garšon, E Banham-Hall, V Plagnol, TR Leahy, ...
Cutting edge: the Foxp3 target miR-155 contributes to the development of regulatory T cells
S Kohlhaas, OA Garden, C Scudamore, M Turner, K Okkenhaug, ...
The Journal of Immunology 182 (5), 2578-2582, 2009
The p110β isoform of phosphoinositide 3-kinase signals downstream of G protein-coupled receptors and is functionally redundant with p110γ
J Guillermet-Guibert, K Bjorklof, A Salpekar, C Gonella, F Ramadani, ...
Proceedings of the National Academy of Sciences 105 (24), 8292-8297, 2008
PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells
DK Finlay, E Rosenzweig, LV Sinclair, C Feijoo-Carnero, JL Hukelmann, ...
The Journal of Experimental Medicine 209 (13), 2441-2453, 2012
Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils
AM Condliffe, K Davidson, KE Anderson, CD Ellson, T Crabbe, ...
Blood 106 (4), 1432-1440, 2005
Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer
K Ali, DR Soond, R Pi˝eiro, T Hagemann, W Pearce, EL Lim, H Bouabe, ...
Nature 510 (7505), 407-411, 2014
Cutting edge: the phosphoinositide 3-kinase p110δ is critical for the function of CD4+ CD25+ Foxp3+ regulatory T cells
DT Patton, OA Garden, WP Pearce, LE Clough, CR Monk, E Leung, ...
The Journal of Immunology 177 (10), 6598-6602, 2006
Signaling by the Phosphoinositide 3-Kinase Family in Immune Cells
K Okkenhaug
Annual review of immunology 31 (1), 2013
A point mutation in CD28 distinguishes proliferative signals from survival signals
K Okkenhaug, L Wu, KM Garza, J La Rose, W Khoo, B Odermatt, TW Mak, ...
Nature immunology 2 (4), 325-332, 2001
Key role of the p110δ isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110δ function in B cells
A Bilancio, K Okkenhaug, M Camps, JL Emery, T Ruckle, C Rommel, ...
Blood 107 (2), 642-650, 2006
Cutting edge: differential roles for phosphoinositide 3-kinases, p110γ and p110δ, in lymphocyte chemotaxis and homing
K Reif, K Okkenhaug, T Sasaki, JM Penninger, B Vanhaesebroeck, ...
The Journal of Immunology 173 (4), 2236-2240, 2004
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