T cell receptor signaling controls Foxp3 expression via PI3K, Akt, and mTOR S Sauer, L Bruno, A Hertweck, D Finlay, M Leleu, M Spivakov, ZA Knight, ... Proceedings of the National Academy of Sciences 105 (22), 7797-7802, 2008 | 894 | 2008 |
PDK1 regulation of mTOR and hypoxia-inducible factor 1 integrate metabolism and migration of CD8+ T cells DK Finlay, E Rosenzweig, LV Sinclair, C Feijoo-Carnero, JL Hukelmann, ... Journal of Experimental Medicine 209 (13), 2441-2453, 2012 | 513 | 2012 |
Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking LV Sinclair, D Finlay, C Feijoo, GH Cornish, A Gray, A Ager, K Okkenhaug, ... Nature immunology 9 (5), 513-521, 2008 | 417 | 2008 |
TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway S Viel, A Marçais, FSF Guimaraes, R Loftus, J Rabilloud, M Grau, ... Science signaling 9 (415), ra19-ra19, 2016 | 399 | 2016 |
Immunometabolism: cellular metabolism turns immune regulator RM Loftus, DK Finlay Journal of Biological Chemistry 291 (1), 1-10, 2016 | 331 | 2016 |
mTORC1-dependent metabolic reprogramming is a prerequisite for NK cell effector function RP Donnelly, RM Loftus, SE Keating, KT Liou, CA Biron, CM Gardiner, ... The Journal of Immunology 193 (9), 4477-4484, 2014 | 312 | 2014 |
Metabolic reprogramming of natural killer cells in obesity limits antitumor responses X Michelet, L Dyck, A Hogan, RM Loftus, D Duquette, K Wei, S Beyaz, ... Nature immunology 19 (12), 1330-1340, 2018 | 281 | 2018 |
Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism AN Macintyre, D Finlay, G Preston, LV Sinclair, CM Waugh, P Tamas, ... Immunity 34 (2), 224-236, 2011 | 253 | 2011 |
Metabolism, migration and memory in cytotoxic T cells D Finlay, DA Cantrell Nature Reviews Immunology 11 (2), 109-117, 2011 | 249 | 2011 |
AMPK α1: A glucose sensor that controls CD 8 T‐cell memory J Rolf, M Zarrouk, DK Finlay, M Foretz, B Viollet, DA Cantrell European journal of immunology 43 (4), 889-896, 2013 | 228 | 2013 |
Srebp-controlled glucose metabolism is essential for NK cell functional responses N Assmann, KL O'Brien, RP Donnelly, L Dyck, V Zaiatz-Bittencourt, ... Nature immunology 18 (11), 1197-1206, 2017 | 192 | 2017 |
Metabolic reprogramming supports IFN-γ production by CD56bright NK cells SE Keating, V Zaiatz-Bittencourt, RM Loftus, C Keane, K Brennan, ... The Journal of Immunology 196 (6), 2552-2560, 2016 | 190 | 2016 |
Immunometabolism and natural killer cell responses KL O’Brien, DK Finlay Nature Reviews Immunology 19 (5), 282-290, 2019 | 187 | 2019 |
Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice RM Loftus, N Assmann, N Kedia-Mehta, KL O’Brien, A Garcia, C Gillespie, ... Nature communications 9 (1), 1-15, 2018 | 160 | 2018 |
Notch‐induced T cell development requires phosphoinositide‐dependent kinase 1 AP Kelly, DK Finlay, HJ Hinton, RG Clarke, E Fiorini, F Radtke, ... The EMBO journal 26 (14), 3441-3450, 2007 | 135 | 2007 |
Glucose, glycolysis and lymphocyte responses RP Donnelly, DK Finlay Molecular immunology 68 (2), 513-519, 2015 | 134 | 2015 |
Competition for nutrients and its role in controlling immune responses N Kedia-Mehta, DK Finlay Nature Communications 10 (1), 1-8, 2019 | 122 | 2019 |
Phosphoinositide 3‐kinase and the mammalian target of rapamycin pathways control T cell migration D Finlay, D Cantrell Annals of the New York Academy of Sciences 1183 (1), 149-157, 2010 | 100 | 2010 |
Canonical TGF-β signaling pathway represses human NK cell metabolism V Zaiatz-Bittencourt, DK Finlay, CM Gardiner The Journal of Immunology 200 (12), 3934-3941, 2018 | 97 | 2018 |
Glucose represses dendritic cell-induced T cell responses SJ Lawless, N Kedia-Mehta, JF Walls, R McGarrigle, O Convery, ... Nature communications 8 (1), 1-14, 2017 | 93 | 2017 |