Sam Alsford
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High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome
S Alsford, DJ Turner, SO Obado, A Sanchez-Flores, L Glover, M Berriman, ...
Genome research 21 (6), 915-924, 2011
High-throughput decoding of antitrypanosomal drug efficacy and resistance
S Alsford, S Eckert, N Baker, L Glover, A Sanchez-Flores, KF Leung, ...
Nature 482 (7384), 232-236, 2012
Tagging a T. brucei RRNA locus improves stable transfection efficiency and circumvents inducible expression position effects
S Alsford, T Kawahara, L Glover, D Horn
Molecular and biochemical parasitology 144 (2), 142-148, 2005
Single-locus targeting constructs for reliable regulated RNAi and transgene expression in Trypanosoma brucei
S Alsford, D Horn
Molecular and biochemical parasitology 161 (1), 76-79, 2008
A sirtuin in the African trypanosome is involved in both DNA repair and telomeric gene silencing but is not required for antigenic variation
S Alsford, T Kawahara, C Isamah, D Horn
Molecular microbiology 63 (3), 724-736, 2007
Genome-wide RNAi screens in African trypanosomes identify the nifurtimox activator NTR and the eflornithine transporter AAT6
N Baker, S Alsford, D Horn
Molecular and biochemical parasitology 176 (1), 55-57, 2011
NUP-1 Is a large coiled-coil nucleoskeletal protein in trypanosomes with lamin-like functions
KN DuBois, S Alsford, JM Holden, J Buisson, M Swiderski, JM Bart, ...
PLoS Biol 10 (3), e1001287, 2012
DNA break site at fragile subtelomeres determines probability and mechanism of antigenic variation in African trypanosomes
L Glover, S Alsford, D Horn
PLoS Pathog 9 (3), e1003260, 2013
Two essential MYST‐family proteins display distinct roles in histone H4K10 acetylation and telomeric silencing in trypanosomes
T Kawahara, TN Siegel, AK Ingram, S Alsford, GAM Cross, D Horn
Molecular microbiology 69 (4), 1054-1068, 2008
Trypanosomatid histones
S Alsford, D Horn
Molecular microbiology 53 (2), 365-372, 2004
VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes
L Glover, S Hutchinson, S Alsford, D Horn
Proceedings of the National Academy of Sciences 113 (26), 7225-7230, 2016
Genetic dissection of drug resistance in trypanosomes
SAM Alsford, JM Kelly, N Baker, D Horn
Parasitology 140 (12), 1478-1491, 2013
Antigenic variation in African trypanosomes: the importance of chromosomal and nuclear context in VSG expression control
L Glover, S Hutchinson, S Alsford, R McCulloch, MC Field, D Horn
Cellular microbiology 15 (12), 1984-1993, 2013
Cell-cycle-regulated control of VSG expression site silencing by histones and histone chaperones ASF1A and CAF-1b in Trypanosoma brucei
S Alsford, D Horn
Nucleic acids research 40 (20), 10150-10160, 2012
Segregation of minichromosomes in trypanosomes: implications for mitotic mechanisms
K Gull, S Alsford, K Ersfeld
Trends in microbiology 6 (8), 319-323, 1998
Cyclic AMP effectors in African trypanosomes revealed by genome-scale RNA interference library screening for resistance to the phosphodiesterase inhibitor CpdA
MK Gould, S Bachmaier, JAM Ali, S Alsford, DNA Tagoe, JC Munday, ...
Antimicrobial agents and chemotherapy 57 (10), 4882-4893, 2013
Genome-scale RNAi screens for high-throughput phenotyping in bloodstream-form African trypanosomes
L Glover, S Alsford, N Baker, DJ Turner, A Sanchez-Flores, S Hutchinson, ...
nature protocols 10 (1), 106-133, 2015
Deletion of a trypanosome telomere leads to loss of silencing and progressive loss of terminal DNA in the absence of cell cycle arrest
L Glover, S Alsford, C Beattie, D Horn
Nucleic acids research 35 (3), 872-880, 2007
Diversity and dynamics of the minichromosomal karyotype in Trypanosoma brucei
S Alsford, B Wickstead, K Ersfeld, K Gull
Molecular and biochemical parasitology 113 (1), 79-88, 2001
Nicotinic acetylcholine receptors on the surface of the blood fluke Schistosoma
M Camacho, S Alsford, A Jones, A Agnew
Molecular and biochemical parasitology 71 (1), 127-134, 1995
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