Martijn H. Brugman
Martijn H. Brugman
GlaxoSmithKline, LUMC, Hannover Medical School, ErasmusMC
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Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients
SJ Howe, MR Mansour, K Schwarzwaelder, C Bartholomae, M Hubank, ...
The Journal of clinical investigation 118 (9), 2008
Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors
U Modlich, S Navarro, D Zychlinski, T Maetzig, S Knoess, MH Brugman, ...
Molecular Therapy 17 (11), 1919-1928, 2009
Stimulation of Id1 expression by bone morphogenetic protein is sufficient and necessary for bone morphogenetic protein–induced activation of endothelial cells
G Valdimarsdottir, MJ Goumans, A Rosendahl, M Brugman, S Itoh, ...
Circulation 106 (17), 2263-2270, 2002
Multipotent stromal cells induce human regulatory T cells through a novel pathway involving skewing of monocytes toward anti‐inflammatory macrophages
SM Melief, E Schrama, MH Brugman, MM Tiemessen, MJ Hoogduijn, ...
Stem Cells 31 (9), 1980-1991, 2013
Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion
TC Luis, BAE Naber, PPC Roozen, MH Brugman, EFE de Haas, ...
Cell stem cell 9 (4), 345-356, 2011
Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy
A Deichmann, S Hacein-Bey-Abina, M Schmidt, A Garrigue, MH Brugman, ...
The Journal of clinical investigation 117 (8), 2225-2232, 2007
Lentiviral vector design and imaging approaches to visualize the early stages of cellular reprogramming
E Warlich, J Kuehle, T Cantz, MH Brugman, T Maetzig, M Galla, ...
Molecular Therapy 19 (4), 782-789, 2011
Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo
K Schwarzwaelder, SJ Howe, M Schmidt, MH Brugman, A Deichmann, ...
The Journal of clinical investigation 117 (8), 2241-2249, 2007
Resistance of mature T cells to oncogene transformation
S Newrzela, K Cornils, Z Li, C Baum, MH Brugman, M Hartmann, J Meyer, ...
Blood, The Journal of the American Society of Hematology 112 (6), 2278-2286, 2008
Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development
TC Luis, M Ichii, MH Brugman, P Kincade, FJT Staal
Leukemia 26 (3), 414-421, 2012
Somatic mutations found in the healthy blood compartment of a 115-yr-old woman demonstrate oligoclonal hematopoiesis
H Holstege, W Pfeiffer, D Sie, M Hulsman, TJ Nicholas, CC Lee, T Ross, ...
Genome research 24 (5), 733-742, 2014
Human thymus contains multipotent progenitors with T/B lymphoid, myeloid, and erythroid lineage potential
F Weerkamp, MRM Baert, MH Brugman, WA Dik, EFE de Haas, TP Visser, ...
Blood 107 (8), 3131-3137, 2006
Next‐generation sequencing for minimal residual disease monitoring in acute myeloid leukemia patients with FLT3‐ITD or NPM1 mutations
F Thol, B Kölking, F Damm, K Reinhardt, JH Klusmann, D Reinhardt, ...
Genes, Chromosomes and Cancer 51 (7), 689-695, 2012
Leukemia induction after a single retroviral vector insertion in Evi1 or Prdm16
U Modlich, A Schambach, MH Brugman, DC Wicke, S Knoess, Z Li, ...
Leukemia 22 (8), 1519-1528, 2008
Retroviral vector insertion sites associated with dominant hematopoietic clones mark “stemness” pathways
OS Kustikova, H Geiger, Z Li, MH Brugman, SM Chambers, CA Shaw, ...
Blood 109 (5), 1897-1907, 2007
Ectopic retroviral expression of LMO2, but not IL2R γ, blocks human T-cell development from CD34+ cells: implications for leukemogenesis in gene therapy
K Pike-Overzet, D de Ridder, F Weerkamp, MRM Baert, MMA Verstegen, ...
Leukemia 21 (4), 754-763, 2007
Cell-intrinsic and vector-related properties cooperate to determine the incidence and consequences of insertional mutagenesis
OS Kustikova, B Schiedlmeier, MH Brugman, M Stahlhut, S Bartels, Z Li, ...
Molecular therapy 17 (9), 1537-1547, 2009
The nuclear effector of Wnt-signaling, Tcf1, functions as a T-cell–specific tumor suppressor for development of lymphomas
MM Tiemessen, MRM Baert, T Schonewille, MH Brugman, F Famili, ...
PLoS biology 10 (11), e1001430, 2012
Alpharetroviral self-inactivating vectors: long-term transgene expression in murine hematopoietic cells and low genotoxicity
JD Suerth, T Maetzig, MH Brugman, N Heinz, JU Appelt, KB Kaufmann, ...
Molecular therapy 20 (5), 1022-1032, 2012
Is IL2RG oncogenic in T-cell development?
K Pike-Overzet, D de Ridder, F Weerkamp, MRM Baert, MM Verstegen, ...
Nature 443 (7109), E5-E5, 2006
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