Martijn H. Brugman
Martijn H. Brugman
GlaxoSmithKline, LUMC, Hannover Medical School, ErasmusMC
No verified email
Title
Cited by
Cited by
Year
Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients
SJ Howe, MR Mansour, K Schwarzwaelder, C Bartholomae, M Hubank, ...
The Journal of clinical investigation 118 (9), 2008
11832008
Insertional transformation of hematopoietic cells by self-inactivating lentiviral and gammaretroviral vectors
U Modlich, S Navarro, D Zychlinski, T Maetzig, S Knoess, MH Brugman, ...
Molecular Therapy 17 (11), 1919-1928, 2009
3952009
Stimulation of Id1 expression by bone morphogenetic protein is sufficient and necessary for bone morphogenetic protein–induced activation of endothelial cells
G Valdimarsdottir, MJ Goumans, A Rosendahl, M Brugman, S Itoh, ...
Circulation 106 (17), 2263-2270, 2002
3482002
Multipotent stromal cells induce human regulatory T cells through a novel pathway involving skewing of monocytes toward anti‐inflammatory macrophages
SM Melief, E Schrama, MH Brugman, MM Tiemessen, MJ Hoogduijn, ...
Stem Cells 31 (9), 1980-1991, 2013
3342013
Canonical wnt signaling regulates hematopoiesis in a dosage-dependent fashion
TC Luis, BAE Naber, PPC Roozen, MH Brugman, EFE de Haas, ...
Cell stem cell 9 (4), 345-356, 2011
2922011
Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy
A Deichmann, S Hacein-Bey-Abina, M Schmidt, A Garrigue, MH Brugman, ...
The Journal of clinical investigation 117 (8), 2225-2232, 2007
2742007
Lentiviral vector design and imaging approaches to visualize the early stages of cellular reprogramming
E Warlich, J Kuehle, T Cantz, MH Brugman, T Maetzig, M Galla, ...
Molecular Therapy 19 (4), 782-789, 2011
2512011
Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo
K Schwarzwaelder, SJ Howe, M Schmidt, MH Brugman, A Deichmann, ...
The Journal of clinical investigation 117 (8), 2241-2249, 2007
2272007
Resistance of mature T cells to oncogene transformation
S Newrzela, K Cornils, Z Li, C Baum, MH Brugman, M Hartmann, J Meyer, ...
Blood, The Journal of the American Society of Hematology 112 (6), 2278-2286, 2008
2152008
Wnt signaling strength regulates normal hematopoiesis and its deregulation is involved in leukemia development
TC Luis, M Ichii, MH Brugman, P Kincade, FJT Staal
Leukemia 26 (3), 414-421, 2012
1942012
Somatic mutations found in the healthy blood compartment of a 115-yr-old woman demonstrate oligoclonal hematopoiesis
H Holstege, W Pfeiffer, D Sie, M Hulsman, TJ Nicholas, CC Lee, T Ross, ...
Genome research 24 (5), 733-742, 2014
1602014
Human thymus contains multipotent progenitors with T/B lymphoid, myeloid, and erythroid lineage potential
F Weerkamp, MRM Baert, MH Brugman, WA Dik, EFE de Haas, TP Visser, ...
Blood 107 (8), 3131-3137, 2006
1192006
Next‐generation sequencing for minimal residual disease monitoring in acute myeloid leukemia patients with FLT3‐ITD or NPM1 mutations
F Thol, B Kölking, F Damm, K Reinhardt, JH Klusmann, D Reinhardt, ...
Genes, Chromosomes and Cancer 51 (7), 689-695, 2012
1162012
Leukemia induction after a single retroviral vector insertion in Evi1 or Prdm16
U Modlich, A Schambach, MH Brugman, DC Wicke, S Knoess, Z Li, ...
Leukemia 22 (8), 1519-1528, 2008
1032008
Retroviral vector insertion sites associated with dominant hematopoietic clones mark “stemness” pathways
OS Kustikova, H Geiger, Z Li, MH Brugman, SM Chambers, CA Shaw, ...
Blood 109 (5), 1897-1907, 2007
982007
Ectopic retroviral expression of LMO2, but not IL2R γ, blocks human T-cell development from CD34+ cells: implications for leukemogenesis in gene therapy
K Pike-Overzet, D de Ridder, F Weerkamp, MRM Baert, MMA Verstegen, ...
Leukemia 21 (4), 754-763, 2007
842007
Cell-intrinsic and vector-related properties cooperate to determine the incidence and consequences of insertional mutagenesis
OS Kustikova, B Schiedlmeier, MH Brugman, M Stahlhut, S Bartels, Z Li, ...
Molecular therapy 17 (9), 1537-1547, 2009
822009
The nuclear effector of Wnt-signaling, Tcf1, functions as a T-cell–specific tumor suppressor for development of lymphomas
MM Tiemessen, MRM Baert, T Schonewille, MH Brugman, F Famili, ...
PLoS biology 10 (11), e1001430, 2012
752012
Alpharetroviral self-inactivating vectors: long-term transgene expression in murine hematopoietic cells and low genotoxicity
JD Suerth, T Maetzig, MH Brugman, N Heinz, JU Appelt, KB Kaufmann, ...
Molecular therapy 20 (5), 1022-1032, 2012
692012
Is IL2RG oncogenic in T-cell development?
K Pike-Overzet, D de Ridder, F Weerkamp, MRM Baert, MM Verstegen, ...
Nature 443 (7109), E5-E5, 2006
692006
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