The oncogenic and clinical implications of lactate induced immunosuppression in the tumour microenvironment C Hayes, CL Donohoe, M Davern, NE Donlon Cancer letters 500, 75-86, 2021 | 100 | 2021 |
Radiotherapy, immunotherapy, and the tumour microenvironment: Turning an immunosuppressive milieu into a therapeutic opportunity NE Donlon, R Power, C Hayes, JV Reynolds, J Lysaght Cancer letters 502, 84-96, 2021 | 93 | 2021 |
Cellular immunotherapies for cancer C Hayes Irish Journal of Medical Science (1971-) 190 (1), 41-57, 2021 | 68 | 2021 |
The tumour immune microenvironment in oesophageal cancer M Davern, NE Donlon, R Power, C Hayes, R King, MR Dunne, ... British Journal of Cancer 125 (4), 479-494, 2021 | 24 | 2021 |
Chemotherapy regimens induce inhibitory immune checkpoint protein expression on stem-like and senescent-like oesophageal adenocarcinoma cells M Davern, NE Donlon, A Sheppard, F O’Connell, C Hayes, A Bhardwaj, ... Translational Oncology 14 (6), 101062, 2021 | 17 | 2021 |
Hypoxia and its impact on the tumour microenvironment of gastroesophageal cancers R King, C Hayes, CL Donohoe, MR Dunne, M Davern, NE Donlon World Journal of Gastrointestinal Oncology 13 (5), 312, 2021 | 12 | 2021 |
Radiation and immunotherapy in upper gastrointestinal cancers: the current state of play NE Donlon, R Power, C Hayes, M Davern, JV Reynolds, J Lysaght International Journal of Molecular Sciences 22 (3), 1071, 2021 | 12 | 2021 |
The impact of esophageal oncological surgery on perioperative immune function; implications for adjuvant immune checkpoint inhibition NE Donlon, M Davern, AD Sheppard, F O’Connell, MR Dunne, C Hayes, ... Frontiers in Immunology 13, 823225, 2022 | 8 | 2022 |
The immune response to major gastrointestinal cancer surgery and potential implications for adjuvant immunotherapy NE Donlon, M Davern, C Hayes, R Power, AD Sheppard, CL Donohoe, ... Critical Reviews in Oncology/Hematology 175, 103729, 2022 | 7 | 2022 |
Impact of COVID-19 on the diagnosis and surgical treatment of colorectal cancer: a national perspective NE Donlon, C Hayes, M Davern, JC Bolger, SC Irwin, WT Butt, ... Diseases of the Colon & Rectum 64 (11), 1305-1309, 2021 | 6 | 2021 |
Cooperation between chemotherapy and immune checkpoint blockade to enhance anti-tumour T cell immunity in oesophageal adenocarcinoma M Davern, NE Donlon, F O’Connell, AD Sheppard, C Hayes, R King, ... Translational Oncology 20, 101406, 2022 | 5 | 2022 |
PD-1 and TIGIT blockade differentially affect tumour cell survival under hypoxia and glucose deprived conditions in oesophageal adenocarcinoma; implications for overcoming … M Davern, MC Fitzgerald, CE Buckley, AB Heeran, NE Donlon, J McGrath, ... Translational oncology 19, 101381, 2022 | 5 | 2022 |
The prognostic value of the lymph node in oesophageal adenocarcinoma; incorporating clinicopathological and immunological profiling NE Donlon, M Davern, A Sheppard, R Power, F O’Connell, AB Heeran, ... Cancers 13 (16), 4005, 2021 | 4 | 2021 |
Nutrient deprivation and hypoxia alter T cell immune checkpoint expression: potential impact for immunotherapy M Davern, NE Donlon, F O’Connell, C Gaughan, C O’Donovan, J McGrath, ... Journal of Cancer Research and Clinical Oncology 149 (8), 5377-5395, 2023 | 3 | 2023 |
FLOT and CROSS chemotherapy regimens alter the frequency of CD27+ and CD69+ T cells in oesophagogastric adenocarcinomas: implications for combination … M Davern, NE Donlon, AS Sheppard, KD Majcher, FO Connell, ... Journal of Cancer Research and Clinical Oncology 149 (7), 3753-3774, 2023 | 2 | 2023 |
PD-1 and TIGIT blockade differentially affect tumour cell survival under hypoxia and glucose deprived conditions in oesophageal adenocarcinoma; implications for overcoming … F O'Connell, J MacDonald, AD Sheppard, JV Reynolds, SG Maher, ... | | 2022 |
Immune Checkpoint Blockade Limits the Immunosuppressive Effects of The Oesophageal Adenocarcinoma Tumour Microenvironment On T-Cells M Davern, N Donlon, C Butler, N Ravi, JV Reynolds, J Lysaght, ... IRISH JOURNAL OF MEDICAL SCIENCE 190 (SUPPL 6), S264-S264, 2021 | | 2021 |
P09. 04 Impact of major oncologic surgery on immune responses in the immediate post-operative setting in oesophageal adenocarcinoma patients; a guide to harnessing the double … NE Donlon, M Davern, A Sheppard, F O’Connell, S Ramjit, C Hayes, ... Journal for ImmunoTherapy of Cancer 9 (Suppl 1), 2021 | | 2021 |
Immune checkpoint blockade limits the immunosuppressive effects exerted by key features of the hostile tumour microenvironment on T cells in oesophageal adenocarcinoma M Davern, NE Donlon, A Sheppard, FO Connell, R King, C Hayes, ... EUROPEAN JOURNAL OF IMMUNOLOGY 51, 189-189, 2021 | | 2021 |
AB107. SOH21AS190. Timing is everything; manipulating the surgery induced immunosuppressive milieu into a therapeutic target NE Donlon, M Davern, A Sheppard, M McClean, S Ramjit, R Power, ... Mesentery and Peritoneum 5, 2021 | | 2021 |