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Giovanna Mallucci
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Depleting neuronal PrP in prion infection prevents disease and reverses spongiosis
G Mallucci, A Dickinson, J Linehan, PC Klohn, S Brandner, J Collinge
Science 302 (5646), 871-874, 2003
7732003
Sustained translational repression by eIF2α-P mediates prion neurodegeneration
JA Moreno, H Radford, D Peretti, JR Steinert, N Verity, MG Martin, ...
Nature 485 (7399), 507-511, 2012
5852012
Sustained translational repression by eIF2α-P mediates prion neurodegeneration
JA Moreno, H Radford, D Peretti, JR Steinert, N Verity, MG Martin, ...
Nature 485 (7399), 507-511, 2012
5852012
Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice
JA Moreno, M Halliday, C Molloy, H Radford, N Verity, JM Axten, CA Ortori, ...
Science translational medicine 5 (206), 206ra138-206ra138, 2013
5442013
Post‐natal knockout of prion protein alters hippocampal CA1 properties, but does not result in neurodegeneration
GR Mallucci, S Ratte, EA Asante, J Linehan, I Gowland, JGR Jefferys, ...
The EMBO journal 21 (3), 202-210, 2002
4812002
Targeting cellular prion protein reverses early cognitive deficits and neurophysiological dysfunction in prion-infected mice
GR Mallucci, MD White, M Farmer, A Dickinson, H Khatun, AD Powell, ...
Neuron 53 (3), 325-335, 2007
2962007
Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing
B Boland, WH Yu, O Corti, B Mollereau, A Henriques, E Bezard, ...
Nature reviews Drug discovery 17 (9), 660-688, 2018
2812018
Partial restoration of protein synthesis rates by the small molecule ISRIB prevents neurodegeneration without pancreatic toxicity
M Halliday, H Radford, Y Sekine, J Moreno, N Verity, J Le Quesne, ...
Cell death & disease 6 (3), e1672-e1672, 2015
2422015
PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia
H Radford, JA Moreno, N Verity, M Halliday, GR Mallucci
Acta neuropathologica 130 (5), 633-642, 2015
2202015
Repurposed drugs targeting eIF2α-P-mediated translational repression prevent neurodegeneration in mice
M Halliday, H Radford, KAM Zents, C Molloy, JA Moreno, NC Verity, ...
Brain 140 (6), 1768-1783, 2017
2112017
Single treatment with RNAi against prion protein rescues early neuronal dysfunction and prolongs survival in mice with prion disease
MD White, M Farmer, I Mirabile, S Brandner, J Collinge, GR Mallucci
Proceedings of the National Academy of Sciences 105 (29), 10238-10243, 2008
2092008
Nerve Injury Induces Robust Allodynia and Ectopic Discharges in Nav1.3 Null Mutant Mice
MA Nassar, MD Baker, A Levato, R Ingram, G Mallucci, SB McMahon, ...
Molecular pain 2, 1744-8069-2-33, 2006
1872006
RBM3 mediates structural plasticity and protective effects of cooling in neurodegeneration
D Peretti, A Bastide, H Radford, N Verity, C Molloy, MG Martin, JA Moreno, ...
Nature 518 (7538), 236-239, 2015
1782015
Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson’s disease
I Celardo, AC Costa, S Lehmann, C Jones, N Wood, NE Mencacci, ...
Cell death & disease 7 (6), e2271-e2271, 2016
1282016
Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson’s disease
R Tufi, S Gandhi, IP De Castro, S Lehmann, PR Angelova, D Dinsdale, ...
Nature cell biology 16 (2), 157-166, 2014
1252014
Targeting the unfolded protein response in neurodegeneration: a new approach to therapy
M Halliday, GR Mallucci
Neuropharmacology 76, 169-174, 2014
1102014
The unfolded protein response: mechanisms and therapy of neurodegeneration
HL Smith, GR Mallucci
Brain 139 (8), 2113-2121, 2016
1082016
The unfolded protein response in neurodegenerative disorders–therapeutic modulation of the PERK pathway
D Hughes, GR Mallucci
The FEBS journal 286 (2), 342-355, 2019
1022019
Rational targeting for prion therapeutics
G Mallucci, J Collinge
Nature Reviews Neuroscience 6 (1), 23-34, 2005
1002005
Astrocyte unfolded protein response induces a specific reactivity state that causes non-cell-autonomous neuronal degeneration
HL Smith, OJ Freeman, AJ Butcher, S Holmqvist, I Humoud, T Schätzl, ...
Neuron 105 (5), 855-866. e5, 2020
862020
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