Andreas C. Joerger

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Alan FershtEmeritus Group Leader, MRC Laboratory of Molecular Biology, University of CambridgeVerified email at cam.ac.uk
Frank M. BoecklerUniv. Professor, Lab for Molecular Design & Pharm. Biophysics, Eberhard Karls University TuebingenVerified email at uni-tuebingen.de
Rainer WilckenFlare TherapeuticsVerified email at flaretx.com
Dmitry VeprintsevProfessor of Molecular and Cellular Pharmacology, University of NottinghamVerified email at nottingham.ac.uk
Stefan KnappUniversity of FrankfurtVerified email at pharmchem.uni-frankfurt.de
Markus Oliver ZimmermannUniversity of TuebingenVerified email at uni-tuebingen.de
Matthias R. BauerNovartis Institutes for BioMedical ResearchVerified email at novartis.com
John SpencerChemistry, University of SussexVerified email at sussex.ac.uk
Andreas LangeUniversity of MuensterVerified email at uni-muenster.de
Andreas KraemerGroup Leader, Structural Genomics ConsortiumVerified email at pharmchem.uni-frankfurt.de
Dimitrios-Ilias BalourdasStructural Genomics Consortium (SGC), Goethe-Universität Frankfurt am MainVerified email at pharmchem.uni-frankfurt.de
Eviatar NatanVerified email at mrc-lmb.cam.ac.uk
Matthias BaudUniversity of SouthamptonVerified email at soton.ac.uk
Carol V RobinsonProfessor of Chemistry University of OxfordVerified email at chem.ox.ac.uk
Mark D AllenIneos Oxford Institute (Oxford Chemistry Dept.)Verified email at chem.ox.ac.uk
Giovanni SettanniFaculty of Physics and Astronomy, Ruhr University BochumVerified email at rub.de
Xiangrui LiuZhejiang UniversityVerified email at zju.edu.cn
Joel KaarProfessor of Chemical and Biological Engineering, University of Colorado BoulderVerified email at colorado.edu
Sjors ScheresMRC Laboratory of Molecular BiologyVerified email at mrc-lmb.cam.ac.uk
Ravi Ramesh PathakTakeda PharmaceuticalsVerified email at takeda.com

Andreas C. Joerger

Structural Genomics Consortium (SGC), Institute of Pharmaceutical Chemistry, Goethe University

Verified email at pharmchem.uni-frankfurt.de

structural biology x-ray crystallography protein evolution p53 drug discovery


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Principles and applications of halogen bonding in medicinal chemistry and chemical biology R Wilcken, MO Zimmermann, A Lange, AC Joerger, FM Boeckler Journal of medicinal chemistry 56 (4), 1363-1388, 2013	1235	2013
Structural biology of the tumor suppressor p53 AC Joerger, AR Fersht Annu. Rev. Biochem. 77 (1), 557-582, 2008	808	2008
The p53 pathway: origins, inactivation in cancer, and emerging therapeutic approaches AC Joerger, AR Fersht Annual review of biochemistry 85 (1), 375-404, 2016	652	2016
Structure–function–rescue: the diverse nature of common p53 cancer mutants AC Joerger, AR Fersht Oncogene 26 (15), 2226-2242, 2007	544	2007
The tumor suppressor p53: from structures to drug discovery AC Joerger, AR Fersht Cold Spring Harbor perspectives in biology 2 (6), a000919, 2010	469	2010
Targeted rescue of a destabilized mutant of p53 by an in silico screened drug FM Boeckler, AC Joerger, G Jaggi, TJ Rutherford, DB Veprintsev, ... Proceedings of the National Academy of Sciences 105 (30), 10360-10365, 2008	441	2008
Structural basis for understanding oncogenic p53 mutations and designing rescue drugs AC Joerger, HC Ang, AR Fersht Proceedings of the National Academy of Sciences 103 (41), 15056-15061, 2006	381	2006
Pathological unfoldomics of uncontrolled chaos: intrinsically disordered proteins and human diseases VN Uversky, V Davé, LM Iakoucheva, P Malaney, SJ Metallo, RR Pathak, ... Chemical reviews 114 (13), 6844-6879, 2014	293	2014
Small molecule induced reactivation of mutant p53 in cancer cells X Liu, R Wilcken, AC Joerger, IS Chuckowree, J Amin, J Spencer, ... Nucleic acids research 41 (12), 6034-6044, 2013	257	2013
Halogen-enriched fragment libraries as leads for drug rescue of mutant p53 R Wilcken, X Liu, MO Zimmermann, TJ Rutherford, AR Fersht, AC Joerger, ... Journal of the American Chemical Society 134 (15), 6810-6818, 2012	248	2012
Crystal structure of a superstable mutant of human p53 core domain: insights into the mechanism of rescuing oncogenic mutations AC Joerger, MD Allen, AR Fersht Journal of Biological Chemistry 279 (2), 1291-1296, 2004	203	2004
Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations AC Joerger, HC Ang, DB Veprintsev, CM Blair, AR Fersht Journal of Biological Chemistry 280 (16), 16030-16037, 2005	199	2005
Effects of common cancer mutations on stability and DNA binding of full-length p53 compared with isolated core domains HC Ang, AC Joerger, S Mayer, AR Fersht Journal of Biological Chemistry 281 (31), 21934-21941, 2006	173	2006
Structural evolution of p53, p63, and p73: implication for heterotetramer formation AC Joerger, S Rajagopalan, E Natan, DB Veprintsev, CV Robinson, ... Proceedings of the National Academy of Sciences 106 (42), 17705-17710, 2009	167	2009
Structural biology of the tumor suppressor p53 and cancer‐associated mutants AC Joerger, AR Fersht Advances in cancer research 97, 1-23, 2007	147	2007
Toward the rational design of p53-stabilizing drugs: probing the surface of the oncogenic Y220C mutant N Basse, JL Kaar, G Settanni, AC Joerger, TJ Rutherford, AR Fersht Chemistry & biology 17 (1), 46-56, 2010	142	2010
Design of a molecular support for cryo-EM structure determination TG Martin, TAM Bharat, AC Joerger, X Bai, F Praetorius, AR Fersht, ... Proceedings of the National Academy of Sciences 113 (47), E7456-E7463, 2016	122	2016
2-Sulfonylpyrimidines: Mild alkylating agents with anticancer activity toward p53-compromised cells MR Bauer, AC Joerger, AR Fersht Proceedings of the National Academy of Sciences 113 (36), E5271-E5280, 2016	115	2016
Interaction of the p53 DNA-binding domain with its n-terminal extension modulates the stability of the p53 tetramer E Natan, C Baloglu, K Pagel, SMV Freund, N Morgner, CV Robinson, ... Journal of molecular biology 409 (3), 358-368, 2011	112	2011
Acetylation of lysine 120 of p53 endows DNA-binding specificity at effective physiological salt concentration E Arbely, E Natan, T Brandt, MD Allen, DB Veprintsev, CV Robinson, ... Proceedings of the National Academy of Sciences 108 (20), 8251-8256, 2011	105	2011

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