| Pan-cancer analysis of whole genomes Nature 578 (7793), 82-93, 2020 | 1662* | 2020 |
| An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers K Chan, SA Roberts, LJ Klimczak, JF Sterling, N Saini, EP Malc, J Kim, ... Nature genetics 47 (9), 1067-1072, 2015 | 404 | 2015 |
| Migrating bubble during break-induced replication drives conservative DNA synthesis N Saini, S Ramakrishnan, R Elango, S Ayyar, Y Zhang, A Deem, G Ira, ... Nature 502 (7471), 389-392, 2013 | 349 | 2013 |
| Molecular evolution of early-onset prostate cancer identifies molecular risk markers and clinical trajectories C Gerhauser, F Favero, T Risch, R Simon, L Feuerbach, Y Assenov, ... Cancer cell 34 (6), 996-1011. e8, 2018 | 231 | 2018 |
| The impact of environmental and endogenous damage on somatic mutation load in human skin fibroblasts N Saini, SA Roberts, LJ Klimczak, K Chan, SA Grimm, S Dai, DC Fargo, ... PLoS genetics 12 (10), 2016 | 101 | 2016 |
| Genomic and evolutionary classification of lung cancer in never smokers T Zhang, P Joubert, N Ansari-Pour, W Zhao, PH Hoang, R Lokanga, ... Nature genetics 53 (9), 1348-1359, 2021 | 99 | 2021 |
| When secondary comes first–the importance of non-canonical DNA structures N Saini, Y Zhang, K Usdin, KS Lobachev Biochimie 95 (2), 117-123, 2013 | 81 | 2013 |
| Genome-wide screen identifies pathways that govern GAA/TTC repeat fragility and expansions in dividing and nondividing yeast cells Y Zhang, AA Shishkin, Y Nishida, D Marcinkowski-Desmond, N Saini, ... Molecular cell 48 (2), 254-265, 2012 | 65 | 2012 |
| Infectious vaccine-derived rubella viruses emerge, persist, and evolve in cutaneous granulomas of children with primary immunodeficiencies L Perelygina, M Chen, S Suppiah, A Adebayo, E Abernathy, M Dorsey, ... PLoS pathogens 15 (10), e1008080, 2019 | 60 | 2019 |
| Similarity between mutation spectra in hypermutated genomes of rubella virus and in SARS-CoV-2 genomes accumulated during the COVID-19 pandemic LJ Klimczak, TA Randall, N Saini, JL Li, DA Gordenin PLoS One 15 (10), e0237689, 2020 | 58 | 2020 |
| APOBEC3B cytidine deaminase targets the non-transcribed strand of tRNA genes in yeast N Saini, SA Roberts, JF Sterling, EP Malc, PA Mieczkowski, DA Gordenin DNA repair 53, 4-14, 2017 | 50 | 2017 |
| Repair of multiple simultaneous double-strand breaks causes bursts of genome-wide clustered hypermutation CJ Sakofsky, N Saini, LJ Klimczak, K Chan, EP Malc, PA Mieczkowski, ... PLoS Biology 17 (9), e3000464, 2019 | 38 | 2019 |
| Mutational signatures of redox stress in yeast single-strand DNA and of aging in human mitochondrial DNA share a common feature NP Degtyareva, N Saini, JF Sterling, VC Placentra, LJ Klimczak, ... PLoS biology 17 (5), e3000263, 2019 | 35 | 2019 |
| Hypermutation in single-stranded DNA N Saini, DA Gordenin DNA repair 91, 102868, 2020 | 34 | 2020 |
| Germline determinants of the somatic mutation landscape in 2,642 cancer genomes SM Waszak, G Tiao, B Zhu, T Rausch, F Muyas, B Rodriguez-Martin, ... BioRxiv, 208330, 2017 | 34 | 2017 |
| UV-exposure, endogenous DNA damage, and DNA replication errors shape the spectra of genome changes in human skin N Saini, CK Giacobone, LJ Klimczak, BN Papas, AB Burkholder, JL Li, ... PLoS genetics 17 (1), e1009302, 2021 | 33 | 2021 |
| Mutation signatures specific to DNA alkylating agents in yeast and cancers N Saini, JF Sterling, CJ Sakofsky, CK Giacobone, LJ Klimczak, ... Nucleic acids research 48 (7), 3692-3707, 2020 | 32 | 2020 |
| Genome-wide screen reveals replication pathway for quasi-palindrome fragility dependent on homologous recombination Y Zhang, N Saini, Z Sheng, KS Lobachev PLoS genetics 9 (12), e1003979, 2013 | 31 | 2013 |
| Fragile DNA Motifs Trigger Mutagenesis at Distant Chromosomal Loci in Saccharomyces cerevisiae N Saini, Y Zhang, Y Nishida, Z Sheng, S Choudhury, P Mieczkowski, ... PLoS genetics 9 (6), e1003551, 2013 | 30 | 2013 |
| Somatic mutation load and spectra: A record of DNA damage and repair in healthy human cells N Saini, DA Gordenin Environmental and molecular mutagenesis 59 (8), 672-686, 2018 | 25 | 2018 |
Dmitry GordeninPI, Mechanisms of Genome Dynamics Group, NIEHSVerified email at niehs.nih.gov
