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James Birtley
James Birtley
Post-doctoral researcher.
Verified email at umassmed.edu
Title
Cited by
Cited by
Year
Regulatory R region of the CFTR chloride channel is a dynamic integrator of phospho-dependent intra-and intermolecular interactions
Z Bozoky, M Krzeminski, R Muhandiram, JR Birtley, A Al-Zahrani, ...
Proceedings of the National Academy of Sciences 110 (47), E4427-E4436, 2013
1762013
Crystal structure of foot-and-mouth disease virus 3C protease: new insights into catalytic mechanism and cleavage specificity
JR Birtley, SR Knox, AM Jaulent, P Brick, RJ Leatherbarrow, S Curry
Journal of Biological Chemistry 280 (12), 11520-11527, 2005
1692005
Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses
E Zervoudi, E Saridakis, JR Birtley, SS Seregin, E Reeves, P Kokkala, ...
Proceedings of the National Academy of Sciences 110 (49), 19890-19895, 2013
1352013
The crystal structure of human endoplasmic reticulum aminopeptidase 2 reveals the atomic basis for distinct roles in antigen processing
JR Birtley, E Saridakis, E Stratikos, IM Mavridis
Biochemistry 51 (1), 286-295, 2012
1162012
Structural insights into the transcriptional and translational roles of Ebp1
TP Monie, AJ Perrin, JR Birtley, TR Sweeney, I Karakasiliotis, Y Chaudhry, ...
The EMBO journal 26 (17), 3936-3944, 2007
1152007
Structural and mutagenic analysis of foot-and-mouth disease virus 3C protease reveals the role of the β-ribbon in proteolysis
TR Sweeney, N Roqué-Rosell, JR Birtley, RJ Leatherbarrow, S Curry
Journal of virology 81 (1), 115-124, 2007
1052007
Role of RNA structure and RNA binding activity of foot-and-mouth disease virus 3C protein in VPg uridylylation and virus replication
A Nayak, IG Goodfellow, KE Woolaway, J Birtley, S Curry, GJ Belsham
Journal of virology 80 (19), 9865-9875, 2006
962006
A common single nucleotide polymorphism in endoplasmic reticulum aminopeptidase 2 induces a specificity switch that leads to altered antigen processing
I Evnouchidou, J Birtley, S Seregin, A Papakyriakou, E Zervoudi, ...
The Journal of Immunology 189 (5), 2383-2392, 2012
952012
Architecture of the cystic fibrosis transmembrane conductance regulator protein and structural changes associated with phosphorylation and nucleotide binding
L Zhang, LA Aleksandrov, Z Zhao, JR Birtley, JR Riordan, RC Ford
Journal of structural biology 167 (3), 242-251, 2009
722009
Structures of the compact helical core domains of feline calicivirus and murine norovirus VPg proteins
EN Leen, KYR Kwok, JR Birtley, PJ Simpson, CV Subba-Reddy, ...
Journal of virology 87 (10), 5318-5330, 2013
532013
Crystallization of foot-and-mouth disease virus 3C protease: surface mutagenesis and a novel crystal-optimization strategy
JR Birtley, S Curry
Acta Crystallographica Section D: Biological Crystallography 61 (5), 646-650, 2005
522005
Shigella depends on SepA to destabilize the intestinal epithelial integrity via cofilin activation
A Maldonado-Contreras, JR Birtley, E Boll, Y Zhao, KL Mumy, J Toscano, ...
Gut Microbes 8 (6), 544-560, 2017
512017
In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls
W Jiang, JR Birtley, SC Hung, W Wang, SH Chiou, C Macaubas, ...
Nature communications 10 (1), 5247, 2019
492019
The allosteric modulation of complement C5 by knob domain peptides
A Macpherson, M Laabei, Z Ahdash, MA Graewert, JR Birtley, ...
Elife 10, e63586, 2021
252021
A continuous assay for foot-and-mouth disease virus 3C protease activity
AM Jaulent, AS Fahy, SR Knox, JR Birtley, N Roqué-Rosell, S Curry, ...
Analytical biochemistry 368 (2), 130-137, 2007
252007
Inactivating mutations and X-ray crystal structure of the tumor suppressor OPCML reveal cancer-associated functions
JR Birtley, M Alomary, E Zanini, J Antony, Z Maben, GC Weaver, ...
Nature communications 10 (1), 3134, 2019
152019
CFTR three-dimensional structure
RC Ford, J Birtley, MF Rosenberg, L Zhang
Cystic Fibrosis: Diagnosis and Protocols, Volume I: Approaches to Study and …, 2011
152011
Emerging roles for the GPI-anchored tumor suppressor OPCML in cancers
J Antony, E Zanini, JR Birtley, H Gabra, C Recchi
Cancer Gene Therapy 28 (1), 18-26, 2021
142021
The chemical synthesis of knob domain antibody fragments
A Macpherson, JR Birtley, RJ Broadbridge, K Brady, MSED Schulze, ...
ACS Chemical Biology 16 (9), 1757-1769, 2021
112021
SepA Enhances Shigella Invasion of Epithelial Cells by Degrading Alpha-1 Antitrypsin and Producing a Neutrophil Chemoattractant
M Meza-Segura, JR Birtley, A Maldonado-Contreras, C Mueller, KJ Simin, ...
MBio 12 (6), e02833-21, 2021
102021
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