| Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity SD Brydges, JL Mueller, MD McGeough, CA Pena, A Misaghi, C Gandhi, ... Immunity 30 (6), 875-887, 2009 | 345 | 2009 |
| C9orf72 ablation causes immune dysregulation characterized by leukocyte expansion, autoantibody production and glomerulonephropathy in mice A Atanasio, V Decman, D White, M Ramos, B Ikiz, HC Lee, CJ Siao, ... Scientific reports 6 (1), 23204, 2016 | 277 | 2016 |
| Divergence of IL-1, IL-18, and cell death in NLRP3 inflammasomopathies SD Brydges, L Broderick, MD McGeough, CA Pena, JL Mueller, ... The Journal of clinical investigation 123 (11), 4695-4705, 2013 | 230 | 2013 |
| Combination cancer immunotherapy targeting PD-1 and GITR can rescue CD8+ T cell dysfunction and maintain memory phenotype B Wang, W Zhang, V Jankovic, J Golubov, P Poon, EM Oswald, C Gurer, ... Science immunology 3 (29), eaat7061, 2018 | 156 | 2018 |
| Constitutively activated NLRP3 inflammasome causes inflammation and abnormal skeletal development in mice SL Bonar, SD Brydges, JL Mueller, MD McGeough, C Pena, D Chen, ... PloS one 7 (4), e35979, 2012 | 115 | 2012 |
| The systemic autoinflammatory diseases: inborn errors of the innate immune system S Brydges, DL Kastner Current Concepts in Autoimmunity and Chronic Inflammation, 127-160, 2006 | 102 | 2006 |
| Genetic and molecular basis of inflammasome-mediated disease HM Hoffman, SD Brydges Journal of Biological Chemistry 286 (13), 10889-10896, 2011 | 98 | 2011 |
| Cutting edge: IL-6 is a marker of inflammation with no direct role in inflammasome-mediated mouse models MD McGeough, CA Pena, JL Mueller, DA Pociask, L Broderick, ... The Journal of Immunology 189 (6), 2707-2711, 2012 | 95 | 2012 |
| Molecular characterization of TgMIC5, a proteolytically processed antigen secreted from the micronemes of Toxoplasma gondii SD Brydges, GD Sherman, S Nockemann, A Loyens, W Däubener, ... Molecular and biochemical parasitology 111 (1), 51-66, 2000 | 86 | 2000 |
| Pyrin modulates the intracellular distribution of PSTPIP1 AL Waite, P Schaner, N Richards, B Balci-Peynircioglu, SL Masters, ... PloS one 4 (7), e6147, 2009 | 69 | 2009 |
| Dissolution of Xylose Metabolism inLactococcus lactis KA Erlandson, JH Park, Wissam, E Khal, HH Kao, P Basaran, S Brydges, ... Applied and environmental microbiology 66 (9), 3974-3980, 2000 | 59 | 2000 |
| Mutations in topoisomerase IIβ result in a B cell immunodeficiency L Broderick, S Yost, D Li, MD McGeough, LM Booshehri, M Guaderrama, ... Nature communications 10 (1), 3644, 2019 | 46 | 2019 |
| Mutation of an unusual mitochondrial targeting sequence of SODB2 produces multiple targeting fates in Toxoplasma gondii SD Brydges, VB Carruthers Journal of cell science 116 (22), 4675-4685, 2003 | 46 | 2003 |
| Monoallelic BMP2 variants predicted to result in haploinsufficiency cause craniofacial, skeletal, and cardiac features overlapping those of 20p12 deletions TY Tan, C Gonzaga-Jauregui, EJ Bhoj, KA Strauss, K Brigatti, ... The American Journal of Human Genetics 101 (6), 985-994, 2017 | 44 | 2017 |
| A transient forward‐targeting element for microneme‐regulated secretion in Toxoplasma gondii SD Brydges, JM Harper, F Parussini, I Coppens, VB Carruthers Biology of the Cell 100 (4), 253-264, 2008 | 42 | 2008 |
| Autoinflammation: translating mechanism to therapy TA Doherty, SD Brydges, HM Hoffman Journal of leukocyte biology 90 (1), 37-47, 2011 | 40 | 2011 |
| Targeted Deletion of MIC5 Enhances Trimming Proteolysis of Toxoplasma Invasion Proteins SD Brydges, XW Zhou, MH Huynh, JM Harper, J Mital, KDZ Adjogble, ... Eukaryotic cell 5 (12), 2174-2183, 2006 | 29 | 2006 |
| Activin A does not drive post-traumatic heterotopic ossification C Hwang, CA Pagani, N Das, S Marini, AK Huber, LQ Xie, J Jimenez, ... Bone 138, 115473, 2020 | 28 | 2020 |
| Anti-ACVR1 antibodies exacerbate heterotopic ossification in fibrodysplasia ossificans progressiva (FOP) by activating FOP-mutant ACVR1 S Aykul, L Huang, L Wang, NM Das, S Reisman, Y Ray, Q Zhang, ... The Journal of Clinical Investigation 132 (12), 2022 | 24 | 2022 |
| Neospora caninum expresses an unusual single-domain Kazal protease inhibitor that is discharged into the parasitophorous vacuole MT Morris, WC Cheng, XW Zhou, SD Brydges, VB Carruthers International journal for parasitology 34 (6), 693-701, 2004 | 23 | 2004 |
