David Thornton
David Thornton
Verified email at manchester.ac.uk - Homepage
Cited by
Cited by
Structure and function of the polymeric mucins in airways mucus
DJ Thornton, K Rousseau, MA McGuckin
Annu. Rev. Physiol. 70, 459-486, 2008
Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis
CK Heazlewood, MC Cook, R Eri, GR Price, SB Tauro, D Taupin, ...
PLoS medicine 5 (3), e54, 2008
Muc5b is required for airway defence
MG Roy, A Livraghi-Butrico, AA Fletcher, MM McElwee, SE Evans, ...
Nature 505 (7483), 412-416, 2014
Heterogeneity of airways mucus: variations in the amounts and glycoforms of the major oligomeric mucins MUC5AC and MUC5B
S Kirkham, JK Sheehan, D Knight, PS Richardson, DJ Thornton
Biochemical Journal 361 (3), 537-546, 2002
From mucins to mucus: toward a more coherent understanding of this essential barrier
DJ Thornton, JK Sheehan
Proceedings of the American Thoracic Society 1 (1), 54-61, 2004
Muc5ac: a critical component mediating the rejection of enteric nematodes
SZ Hasnain, CM Evans, M Roy, AL Gallagher, KN Kindrachuk, L Barron, ...
The Journal of experimental medicine 208 (5), 893-900, 2011
Respiratory mucins: identification of core proteins and glycoforms
DJ Thornton, I Carlstedt, M Howard, PL Devine, MR Price, JK Sheehan
Biochemical Journal 316 (3), 967-975, 1996
Identification of two glycoforms of the MUC5B mucin in human respiratory mucus: evidence for a cysteine-rich sequence repeated within the molecule
DJ Thornton, M Howard, N Khan, JK Sheehan
Journal of Biological Chemistry 272 (14), 9561-9566, 1997
Mucin gene deficiency in mice impairs host resistance to an enteric parasitic infection
SZ Hasnain, H Wang, JE Ghia, N Haq, Y Deng, A Velcich, RK Grencis, ...
Gastroenterology 138 (5), 1763-1771. e5, 2010
Tracheobronchial air-liquid interface cell culture: a model for innate mucosal defense of the upper airways?
M Kesimer, S Kirkham, RJ Pickles, AG Henderson, NE Alexis, G DeMaria, ...
American Journal of Physiology-Lung Cellular and Molecular Physiology 296 (1 …, 2009
Salivary mucin MG1 is comprised almost entirely of different glycosylated forms of the MUC5B gene product
DJ Thornton, N Khan, R Mehrotra, M Howard, JK Sheehan, E Veerman, ...
Glycobiology 9 (3), 293-302, 1999
Calcium-dependent protein interactions in MUC5B provide reversible cross-links in salivary mucus
BDE Raynal, TE Hardingham, JK Sheehan, DJ Thornton
Journal of Biological Chemistry 278 (31), 28703-28710, 2003
Mucus glycoproteins from ‘normal’human tracheobronchial secretion
DJ Thornton, JR Davies, M Kraayenbrink, PS Richardson, JK Sheehan, ...
Biochemical Journal 265 (1), 179-186, 1990
Identification in vitreous and molecular cloning of opticin, a novel member of the family of leucine-rich repeat proteins of the extracellular matrix
AJ Reardon, M Le Goff, MD Briggs, D McLeod, JK Sheehan, DJ Thornton, ...
Journal of Biological Chemistry 275 (3), 2123-2129, 2000
Quantitation of mucus glycoproteins blotted onto nitrocellulose membranes
DJ Thornton, DF Holmes, JK Sheehan, I Carlstedt
Analytical biochemistry 182 (1), 160-164, 1989
Analysis of respiratory mucus glycoproteins in asthma: a detailed study from a patient who died in status asthmaticus.
JK Sheehan, PS Richardson, DC Fung, M Howard, DJ Thornton
American journal of respiratory cell and molecular biology 13 (6), 748-756, 1995
MUC5B is the major mucin in the gel phase of sputum in chronic obstructive pulmonary disease
S Kirkham, U Kolsum, K Rousseau, D Singh, J Vestbo, DJ Thornton
American journal of respiratory and critical care medicine 178 (10), 1033-1039, 2008
Targeted induction of endoplasmic reticulum stress induces cartilage pathology
MH Rajpar, B McDermott, L Kung, R Eardley, L Knowles, M Heeran, ...
PLoS genetics 5 (10), e1000691, 2009
Physical characterization of a low-charge glycoform of the MUC5B mucin comprising the gel-phase of an asthmatic respiratory mucous plug
Biochemical Journal 338 (2), 507-513, 1999
Regulation of MUC5AC mucin secretion and airway surface liquid metabolism by IL-1β in human bronchial epithelia
T Gray, R Coakley, A Hirsh, D Thornton, S Kirkham, JS Koo, L Burch, ...
American Journal of Physiology-Lung Cellular and Molecular Physiology 286 (2 …, 2004
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