jayakanth kankanala
jayakanth kankanala
Center for drug design, University of Minnesota
Verified email at umn.edu
Title
Cited by
Cited by
Year
Design, synthesis, biochemical, and antiviral evaluations of C6 benzyl and C6 biarylmethyl substituted 2-hydroxylisoquinoline-1, 3-diones: dual inhibition against HIV reverse…
SKV Vernekar, Z Liu, E Nagy, L Miller, KA Kirby, DJ Wilson, J Kankanala, ...
Journal of medicinal chemistry 58 (2), 651-664, 2015
802015
Structure‐guided design affirms inhibitors of hepatitis C virus p7 as a viable class of antivirals targeting virion release
TL Foster, GS Thompson, AP Kalverda, J Kankanala, M Bentham, ...
Hepatology 59 (2), 408-422, 2014
572014
5′-Silylated 3′-1, 2, 3-triazolyl thymidine analogues as inhibitors of West Nile virus and dengue virus
SKV Vernekar, L Qiu, J Zhang, J Kankanala, H Li, RJ Geraghty, Z Wang
Journal of medicinal chemistry 58 (9), 4016-4028, 2015
482015
Design, synthesis, and biological evaluations of hydroxypyridonecarboxylic acids as inhibitors of HIV reverse transcriptase associated RNase H
J Kankanala, KA Kirby, F Liu, L Miller, E Nagy, DJ Wilson, MA Parniak, ...
Journal of medicinal chemistry 59 (10), 5051-5062, 2016
452016
Isoquinoline-1, 3-diones as selective inhibitors of tyrosyl DNA phosphodiesterase II (TDP2)
J Kankanala, C Marchand, M Abdelmalak, H Aihara, Y Pommier, Z Wang
Journal of medicinal chemistry 59 (6), 2734-2746, 2016
362016
A combinatorial in silico and cellular approach to identify a new class of compounds that target VEGFR2 receptor tyrosine kinase activity and angiogenesis
J Kankanala, AM Latham, AP Johnson, S Homer‐Vanniasinkam, ...
British journal of pharmacology 166 (2), 737-748, 2012
312012
3-Hydroxypyrimidine-2,4-dione-5-N-benzylcarboxamides Potently Inhibit HIV-1 Integrase and RNase H
B Wu, J Tang, DJ Wilson, AD Huber, MC Casey, J Ji, J Kankanala, J Xie, ...
Journal of medicinal chemistry 59 (13), 6136-6148, 2016
302016
Double-winged 3-hydroxypyrimidine-2, 4-diones: potent and selective inhibition against HIV-1 RNase H with significant antiviral activity
SKV Vernekar, J Tang, B Wu, AD Huber, MC Casey, N Myshakina, ...
Journal of medicinal chemistry 60 (12), 5045-5056, 2017
262017
Deazaflavin inhibitors of tyrosyl-DNA phosphodiesterase 2 (TDP2) specific for the human enzyme and active against cellular TDP2
C Marchand, M Abdelmalak, J Kankanala, S Huang, E Kiselev, K Fesen, ...
ACS chemical biology 11 (7), 1925-1933, 2016
222016
Design, synthesis and biological evaluations of N-Hydroxy thienopyrimidine-2, 4-diones as inhibitors of HIV reverse transcriptase-associated RNase H
J Kankanala, KA Kirby, AD Huber, MC Casey, DJ Wilson, SG Sarafianos, ...
European journal of medicinal chemistry 141, 149-161, 2017
202017
Indolinones and anilinophthalazines differentially target VEGF‐A‐and basic fibroblast growth factor‐mediated responses in primary human endothelial cells
AM Latham, AF Bruns, J Kankanala, AP Johnson, CWG Fishwick, ...
British journal of pharmacology 165 (1), 245-259, 2012
162012
6-Biphenylmethyl-3-hydroxypyrimidine-2, 4-diones potently and selectively inhibited HIV reverse transcriptase-associated RNase H
L Wang, J Tang, AD Huber, MC Casey, KA Kirby, DJ Wilson, J Kankanala, ...
European journal of medicinal chemistry 156, 680-691, 2018
142018
Inhibition of human cytomegalovirus pUL89 terminase subunit blocks virus replication and genome cleavage
Y Wang, L Mao, J Kankanala, Z Wang, RJ Geraghty
Journal of virology 91 (3), 2017
142017
In silico design and biological evaluation of a dual specificity kinase inhibitor targeting cell cycle progression and angiogenesis
AM Latham, J Kankanala, GW Fearnley, MC Gage, MT Kearney, ...
PloS one 9 (11), e110997, 2014
122014
Bimetallic (Cu/Pd) catalytic cascade reactions to 3, 3-disubstituted oxindole analogues
G Packer, K Lepre, J Kankanala, V Sridharan
RSC Advances 4 (7), 3457-3460, 2014
122014
6-Arylthio-3-hydroxypyrimidine-2, 4-diones potently inhibited HIV reverse transcriptase-associated RNase H with antiviral activity
L Wang, J Tang, AD Huber, MC Casey, KA Kirby, DJ Wilson, J Kankanala, ...
European journal of medicinal chemistry 156, 652-665, 2018
112018
Triazolopyrimidine and triazolopyridine scaffolds as TDP2 inhibitors
CJA Ribeiro, J Kankanala, J Xie, J Williams, H Aihara, Z Wang
Bioorganic & medicinal chemistry letters 29 (2), 257-261, 2019
102019
Toward structurally novel and metabolically stable HIV-1 capsid-targeting small molecules
SKV Vernekar, RL Sahani, MC Casey, J Kankanala, L Wang, KA Kirby, ...
Viruses 12 (4), 452, 2020
92020
New fluorescence-based high-throughput screening assay for small molecule inhibitors of tyrosyl-DNA phosphodiesterase 2 (TDP2)
CJA Ribeiro, J Kankanala, K Shi, K Kurahashi, E Kiselev, A Ravji, ...
European Journal of Pharmaceutical Sciences 118, 67-79, 2018
92018
The substrate-binding cap of the UDP-diacylglucosamine pyrophosphatase LpxH is highly flexible, enabling facile substrate binding and product release
TE Bohl, P Ieong, JK Lee, T Lee, J Kankanala, K Shi, Demir, ...
Journal of Biological Chemistry 293 (21), 7969-7981, 2018
92018
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Articles 1–20