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anthony lagnado
anthony lagnado
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Year
Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease
LTJ Hickson, LGPL Prata, SA Bobart, TK Evans, N Giorgadze, SK Hashmi, ...
EBioMedicine 47, 446-456, 2019
8172019
Length‐independent telomere damage drives post‐mitotic cardiomyocyte senescence
R Anderson, A Lagnado, D Maggiorani, A Walaszczyk, E Dookun, ...
The EMBO journal 38 (5), e100492, 2019
3652019
Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence
MG Vizioli, T Liu, KN Miller, NA Robertson, K Gilroy, AB Lagnado, ...
Genes & development 34 (5-6), 428-445, 2020
2202020
NFκB1 is a suppressor of neutrophil-driven hepatocellular carcinoma
CL Wilson, D Jurk, N Fullard, P Banks, A Page, S Luli, AM Elsharkawy, ...
Nature communications 6 (1), 6818, 2015
1702015
Senescent human melanocytes drive skin ageing via paracrine telomere dysfunction
S Victorelli, A Lagnado, J Halim, W Moore, D Talbot, K Barrett, J Chapman, ...
The EMBO journal 38 (23), e101982, 2019
1582019
Neutrophils induce paracrine telomere dysfunction and senescence in ROS‐dependent manner
A Lagnado, J Leslie, MH Ruchaud‐Sparagano, S Victorelli, P Hirsova, ...
The EMBO journal 40 (9), e106048, 2021
1132021
Corrigendum to ‘Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease …
LTJ Hickson, LGPL Prata, SA Bobart, TK Evans, N Giorgadze, SK Hashmi, ...
EBioMedicine 52, 2020
912020
Targeted reduction of senescent cell burden alleviates focal radiotherapy‐related bone loss
A Chandra, AB Lagnado, JN Farr, DG Monroe, S Park, C Hachfeld, ...
Journal of Bone and Mineral Research 35 (6), 1119-1131, 2020
862020
Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk
LD Cassidy, ARJ Young, CNJ Young, EJ Soilleux, E Fielder, BM Weigand, ...
Nature communications 11 (1), 307, 2020
732020
Rapamycin improves healthspan but not inflammaging in nfκb1−/− mice
C Correia‐Melo, J Birch, E Fielder, D Rahmatika, J Taylor, J Chapman, ...
Aging cell 18 (1), e12882, 2019
682019
Accelerated osteocyte senescence and skeletal fragility in mice with type 2 diabetes
BA Eckhardt, JL Rowsey, BS Thicke, DG Fraser, KL O’Grady, OP Bondar, ...
JCI insight 5 (9), 2020
672020
Characterization of cellular senescence in aging skeletal muscle
X Zhang, L Habiballa, Z Aversa, YE Ng, AE Sakamoto, DA Englund, ...
Nature aging 2 (7), 601-615, 2022
632022
Targeted clearance of p21‐ but not p16‐positive senescent cells prevents radiation‐induced osteoporosis and increased marrow adiposity
A Chandra, AB Lagnado, JN Farr, M Doolittle, T Tchkonia, JL Kirkland, ...
Aging Cell 21 (5), e13602, 2022
422022
Apoptotic stress causes mtDNA release during senescence and drives the SASP
S Victorelli, H Salmonowicz, J Chapman, H Martini, MG Vizioli, JS Riley, ...
Nature 622 (7983), 627-636, 2023
322023
Cytoplasmic innate immune sensing by the caspase-4 non-canonical inflammasome promotes cellular senescence
I Fernández-Duran, A Quintanilla, N Tarrats, J Birch, P Hari, FR Millar, ...
Cell Death & Differentiation 29 (6), 1267-1282, 2022
192022
Spatial mapping of cellular senescence: emerging challenges and opportunities
AU Gurkar, AA Gerencser, AL Mora, AC Nelson, AR Zhang, AB Lagnado, ...
Nature aging 3 (7), 776-790, 2023
182023
Bone marrow adiposity in models of radiation‐and aging‐related bone loss is dependent on cellular senescence
A Chandra, AB Lagnado, JN Farr, M Schleusner, DG Monroe, D Saul, ...
Journal of Bone and Mineral Research 37 (5), 997-1011, 2020
162020
Local senolysis in aged mice only partially replicates the benefits of systemic senolysis
JN Farr, D Saul, ML Doolittle, J Kaur, JL Rowsey, SJ Vos, MN Froemming, ...
The Journal of clinical investigation 133 (8), 2023
152023
Cellular senescence is increased in airway smooth muscle cells of elderly persons with asthma
A Aghali, L Khalfaoui, AB Lagnado, LY Drake, JJ Teske, CM Pabelick, ...
American Journal of Physiology-Lung Cellular and Molecular Physiology 323 (5 …, 2022
132022
Length-independent telomere damage drives cardiomyocyte senescence
R Anderson, A Lagnado, D Maggiorani, A Walaszczyk, E Dookun, ...
bioRxiv, 394809, 2018
62018
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