Protein serine/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities DWC Li, JP Liu, PC Schmid, R Schlosser, H Feng, WB Liu, Q Yan, L Gong, ... Oncogene 25 (21), 3006-3022, 2006 | 131 | 2006 |
Protein phosphatase-1 regulates Akt1 signal transduction pathway to control gene expression, cell survival and differentiation L Xiao, LL Gong, D Yuan, M Deng, XM Zeng, LL Chen, L Zhang, Q Yan, ... Cell Death & Differentiation 17 (9), 1448-1462, 2010 | 117 | 2010 |
Sumoylation activates the transcriptional activity of Pax-6, an important transcription factor for eye and brain development Q Yan, L Gong, M Deng, L Zhang, S Sun, J Liu, H Ma, D Yuan, PC Chen, ... Proceedings of the National Academy of Sciences 107 (49), 21034-21039, 2010 | 114 | 2010 |
Sumoylation Differentially Regulates Sp1 to Control Cell Differentiation 3** Lili Gong1,2*, Wei-Ke Ji1*, Xiao-Hui Hu1,3*, Wen Proceedings of the National Academy of Sciences of the United States of America, 2014 | 86* | 2014 |
αA-and αB-crystallins interact with caspase-3 and Bax to guard mouse lens development WF Hu, L Gong, Z Cao, H Ma, W Ji, M Deng, M Liu, XH Hu, P Chen, Q Yan, ... Current molecular medicine 12 (2), 177-187, 2012 | 76 | 2012 |
Protein phosphatase-1 modulates the function of Pax-6, a transcription factor controlling brain and eye development Q Yan, WB Liu, J Qin, J Liu, HG Chen, X Huang, L Chen, S Sun, M Deng, ... Journal of biological chemistry 282 (19), 13954-13965, 2007 | 62 | 2007 |
Nuclear PTEN Tumor-Suppressor Functions Through Maintaining Heterochromatin Structure GBMSYL Lili Gong, Jeane M. Govan, Elizabeth B. Evans, Hui Dai, Edward Wang ... Cell Cycle, 2015 | 53 | 2015 |
Paeoniflorin suppresses pancreatic cancer cell growth by upregulating HTRA3 expression Y Li, L Gong, R Qi, Q Sun, X Xia, H He, J Ren, O Zhu, D Zhuo Drug Design, Development and Therapy, 2481-2491, 2017 | 45 | 2017 |
hTERT extends proliferative lifespan and prevents oxidative stress-induced apoptosis in human lens epithelial cells XQ Huang, J Wang, JP Liu, H Feng, WB Liu, Q Yan, Y Liu, SM Sun, ... Investigative ophthalmology & visual science 46 (7), 2503-2513, 2005 | 45 | 2005 |
Apoptosis: its functions and control in the ocular lens L Zhang, Q Yan, JP Liu, LJ Zou, J Liu, S Sun, M Deng, L Gong, WK Ji, ... Current molecular medicine 10 (9), 864-875, 2010 | 43 | 2010 |
Human telomerase reverse transcriptase immortalizes bovine lens epithelial cells and suppresses differentiation through regulation of the ERK signaling pathway J Wang, H Feng, XQ Huang, H Xiang, YW Mao, JP Liu, Q Yan, WB Liu, ... Journal of Biological Chemistry 280 (24), 22776-22787, 2005 | 37 | 2005 |
Knockdown of Akt1 promotes Akt2 upregulation and resistance to oxidative-stress-induced apoptosis through control of multiple signaling pathways L Zhang, S Sun, J Zhou, J Liu, JH Lv, XQ Yu, C Li, L Gong, Q Yan, M Deng, ... Antioxidants & redox signaling 15 (1), 1-17, 2011 | 36 | 2011 |
Transcriptional regulation of PP2A-Aα is mediated by multiple factors including AP-2α, CREB, ETS-1, and SP-1 HG Chen, WJ Han, M Deng, J Qin, D Yuan, JP Liu, L Xiao, L Gong, ... PLoS One 4 (9), e7019, 2009 | 36 | 2009 |
Inhibition of cGAS-STING by JQ1 alleviates oxidative stress-induced retina inflammation and degeneration M Zou, Q Ke, Q Nie, R Qi, X Zhu, W Liu, X Hu, Q Sun, JL Fu, X Tang, Y Liu, ... Cell Death & Differentiation 29 (9), 1816-1833, 2022 | 35 | 2022 |
Heterochromatin protects retinal pigment epithelium cells from oxidative damage by silencing p53 target genes L Gong, F Liu, Z Xiong, R Qi, Z Luo, X Gong, Q Nie, Q Sun, YF Liu, W Qing, ... Proceedings of the National Academy of Sciences 115 (17), E3987-E3995, 2018 | 32 | 2018 |
The tumor suppressor p53 regulates c-Maf and Prox-1 to control lens differentiation F Y Liu, X C Tang, M Deng, P Chen, W Ji, X Zhang, L Gong, Z Woodward, ... Current molecular medicine 12 (8), 917-928, 2012 | 30 | 2012 |
The small heat shock protein αA-crystallin is expressed in pancreas and acts as a negative regulator of carcinogenesis M Deng, PC Chen, S Xie, J Zhao, L Gong, J Liu, L Zhang, S Sun, J Liu, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1802 (7-8 …, 2010 | 30 | 2010 |
The p53-Bak apoptotic signaling axis plays an essential role in regulating differentiation of the ocular lens M Deng, P Chen, F Liu, S Fu, H Tang, Y Fu, Z Xiong, S Hui, W Ji, X Zhang, ... Current molecular medicine 12 (8), 901-916, 2012 | 29 | 2012 |
Alpha-crystallins and tumorigenesis P Chen, W Ji, FY Liu, HZ Tang, S Fu, X Zhang, M Liu, L Gong, M Deng, ... Current molecular medicine 12 (9), 1164-1173, 2012 | 26 | 2012 |
Sumoylation in cellular senescence and aging L Gong, Q Sun, D W-C Li Current molecular medicine 16 (10), 871-876, 2016 | 23 | 2016 |