|RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF|
PI Poulikakos, C Zhang, G Bollag, KM Shokat, N Rosen
Nature 464 (7287), 427-430, 2010
|RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF (V600E)|
PI Poulikakos, Y Persaud, M Janakiraman, X Kong, C Ng, G Moriceau, ...
Nature 480 (7377), 387-390, 2011
|Targeting RAS–ERK signalling in cancer: promises and challenges|
AA Samatar, PI Poulikakos
Nature reviews Drug discovery 13 (12), 928-942, 2014
|The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner|
EW Joseph, CA Pratilas, PI Poulikakos, M Tadi, W Wang, BS Taylor, ...
Proceedings of the National Academy of Sciences 107 (33), 14903-14908, 2010
|Relief of profound feedback inhibition of mitogenic signaling by RAF inhibitors attenuates their activity in BRAFV600E melanomas|
P Lito, CA Pratilas, EW Joseph, M Tadi, E Halilovic, M Zubrowski, ...
Cancer cell 22 (5), 668-682, 2012
|mTOR kinase inhibition causes feedback-dependent biphasic regulation of AKT signaling|
VS Rodrik-Outmezguine, S Chandarlapaty, NC Pagano, PI Poulikakos, ...
Cancer discovery 1 (3), 248-259, 2011
|Mutually exclusive recurrent somatic mutations in MAP2K1 and BRAF support a central role for ERK activation in LCH pathogenesis|
R Chakraborty, OA Hampton, X Shen, SJ Simko, A Shih, H Abhyankar, ...
Blood, The Journal of the American Society of Hematology 124 (19), 3007-3015, 2014
|RAD001 inhibits human ovarian cancer cell proliferation, enhances cisplatin-induced apoptosis, and prolongs survival in an ovarian cancer model|
S Mabuchi, DA Altomare, M Cheung, L Zhang, PI Poulikakos, HH Hensley, ...
Clinical cancer research 13 (14), 4261-4270, 2007
|BRAF mutants evade ERK-dependent feedback by different mechanisms that determine their sensitivity to pharmacologic inhibition|
Z Yao, NM Torres, A Tao, Y Gao, L Luo, Q Li, E de Stanchina, ...
Cancer cell 28 (3), 370-383, 2015
|Mutant BRAF melanomas—dependence and resistance|
PI Poulikakos, N Rosen
Cancer cell 19 (1), 11-15, 2011
|Positive feedback regulation between AKT activation and fatty acid synthase expression in ovarian carcinoma cells|
HQ Wang, DA Altomare, KL Skele, PI Poulikakos, FP Kuhajda, ...
Oncogene 24 (22), 3574-3582, 2005
|New perspectives for targeting RAF kinase in human cancer|
Z Karoulia, E Gavathiotis, PI Poulikakos
Nature Reviews Cancer 17 (11), 676-691, 2017
|Re-expression of the tumor suppressor NF2/merlin inhibits invasiveness in mesothelioma cells and negatively regulates FAK|
PI Poulikakos, GH Xiao, R Gallagher, S Jablonski, SC Jhanwar, JR Testa
Oncogene 25 (44), 5960-5968, 2006
|Enhanced inhibition of ERK signaling by a novel allosteric MEK inhibitor, CH5126766, that suppresses feedback reactivation of RAF activity|
N Ishii, N Harada, EW Joseph, K Ohara, T Miura, H Sakamoto, Y Matsuda, ...
Cancer research 73 (13), 4050-4060, 2013
|Human follicle-stimulating hormone (FSH) receptor interacts with the adaptor protein APPL1 in HEK 293 cells: potential involvement of the PI3K pathway in FSH signaling|
CA Nechamen, RM Thomas, BD Cohen, G Acevedo, PI Poulikakos, ...
Biology of reproduction 71 (2), 629-636, 2004
|Resistance to MEK inhibitors: should we co-target upstream?|
PI Poulikakos, DB Solit
Science signaling 4 (166), pe16-pe16, 2011
|An integrated model of RAF inhibitor action predicts inhibitor activity against oncogenic BRAF signaling|
Z Karoulia, Y Wu, TA Ahmed, Q Xin, J Bollard, C Krepler, X Wu, C Zhang, ...
Cancer cell 30 (3), 485-498, 2016
|Growth inhibition and induction of apoptosis in mesothelioma cells by selenium and dependence on selenoprotein SEP15 genotype|
S Apostolou, JO Klein, Y Mitsuuchi, JN Shetler, PI Poulikakos, ...
Oncogene 23 (29), 5032-5040, 2004
|Personalized preclinical trials in BRAF inhibitor–resistant patient-derived xenograft models identify second-line combination therapies|
C Krepler, M Xiao, K Sproesser, PA Brafford, B Shannan, M Beqiri, Q Liu, ...
Clinical Cancer Research 22 (7), 1592-1602, 2016
|Alternative genetic mechanisms of BRAF activation in Langerhans cell histiocytosis|
R Chakraborty, TM Burke, OA Hampton, DJ Zinn, KPH Lim, H Abhyankar, ...
Blood, The Journal of the American Society of Hematology 128 (21), 2533-2537, 2016