| The value of sonography in the detection of bone erosions in patients with rheumatoid arthritis: a comparison with conventional radiography RJ Wakefield, WW Gibbon, PG Conaghan, P O'Connor, D McGonagle, ... Arthritis & Rheumatism 43 (12), 2762-2770, 2000 | 1061 | 2000 |
| Genome-wide association study of CNVs in 16,000 cases of eight common diseases and 3,000 shared controls Nature 464 (7289), 713-720, 2010 | 931 | 2010 |
| Human CD4+CD25+ cells: a naturally occurring population of regulatory T cells WF Ng, PJ Duggan, F Ponchel, G Matarese, G Lombardi, AD Edwards, ... Blood, The Journal of the American Society of Hematology 98 (9), 2736-2744, 2001 | 800 | 2001 |
| Real-time PCR based on SYBR-Green I fluorescence: an alternative to the TaqMan assay for a relative quantification of gene rearrangements, gene amplifications and micro gene … F Ponchel, C Toomes, K Bransfield, FT Leong, SH Douglas, SL Field, ... BMC biotechnology 3, 1-13, 2003 | 594 | 2003 |
| Cytokines in rheumatoid arthritis—shaping the immunological landscape IB McInnes, CD Buckley, JD Isaacs Nature Reviews Rheumatology 12 (1), 63-68, 2016 | 542 | 2016 |
| Updated consensus statement on the use of rituximab in patients with rheumatoid arthritis MH Buch, JS Smolen, N Betteridge, FC Breedveld, G Burmester, T Dörner, ... Annals of the rheumatic diseases 70 (6), 909-920, 2011 | 514 | 2011 |
| Tofacitinib in combination with nonbiologic disease-modifying antirheumatic drugs in patients with active rheumatoid arthritis: a randomized trial J Kremer, ZG Li, S Hall, R Fleischmann, M Genovese, E Martin-Mola, ... Annals of internal medicine 159 (4), 253-261, 2013 | 504 | 2013 |
| Efficacy and safety of secukinumab, a fully human anti-interleukin-17A monoclonal antibody, in patients with moderate-to-severe psoriatic arthritis: a 24-week, randomised … IB McInnes, J Sieper, J Braun, P Emery, D van der Heijde, JD Isaacs, ... Annals of the rheumatic diseases 73 (2), 349-356, 2014 | 463 | 2014 |
| Elucidation of the relationship between synovitis and bone damage: a randomized magnetic resonance imaging study of individual joints in patients with early rheumatoid arthritis PG Conaghan, P O'Connor, D McGonagle, P Astin, RJ Wakefield, ... Arthritis & Rheumatism 48 (1), 64-71, 2003 | 462 | 2003 |
| Adult human fibroblasts are potent immunoregulatory cells and functionally equivalent to mesenchymal stem cells MA Haniffa, XN Wang, U Holtick, M Rae, JD Isaacs, AM Dickinson, ... The Journal of Immunology 179 (3), 1595-1604, 2007 | 457 | 2007 |
| Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: cross-sectional findings from the Newcastle 85+ Study J Collerton, C Martin-Ruiz, K Davies, CM Hilkens, J Isaacs, C Kolenda, ... Mechanisms of ageing and development 133 (6), 456-466, 2012 | 441 | 2012 |
| Efficacy and safety of different doses and retreatment of rituximab: a randomised, placebo-controlled trial in patients who are biological naive with active rheumatoid … P Emery, A Deodhar, WF Rigby, JD Isaacs, B Combe, AJ Racewicz, ... Annals of the rheumatic diseases 69 (9), 1629-1635, 2010 | 438 | 2010 |
| Integrated safety in tocilizumab clinical trials MH Schiff, JM Kremer, A Jahreis, E Vernon, JD Isaacs, ... Arthritis research & therapy 13, 1-13, 2011 | 408 | 2011 |
| Mechanism of action of methotrexate in rheumatoid arthritis, and the search for biomarkers PM Brown, AG Pratt, JD Isaacs Nature Reviews Rheumatology 12 (12), 731-742, 2016 | 396 | 2016 |
| Humanised monoclonal antibody therapy for rheumatoid arthritis JD Isaacs, G Hale, SP Cobbold, H Waldmann, RA Watts, BL Hazleman, ... The Lancet 340 (8822), 748-752, 1992 | 385 | 1992 |
| Novel therapies for immune-mediated inflammatory diseases: what can we learn from their use in rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, psoriasis … KF Baker, JD Isaacs Annals of the rheumatic diseases 77 (2), 175-187, 2018 | 382 | 2018 |
| Mechanism of first-dose cytokine-release syndrome by CAMPATH 1-H: involvement of CD16 (FcgammaRIII) and CD11a/CD18 (LFA-1) on NK cells. MG Wing, T Moreau, J Greenwood, RM Smith, G Hale, J Isaacs, ... The Journal of clinical investigation 98 (12), 2819-2826, 1996 | 358 | 1996 |
| Early rheumatoid arthritis is associated with a deficit in the CD4 + CD25 high regulatory T cell population in peripheral blood CA Lawson, AK Brown, V Bejarano, SH Douglas, CH Burgoyne, ... Rheumatology 45 (10), 1210-1217, 2006 | 341 | 2006 |
| Biologic therapies in rheumatology: lessons learned, future directions V Strand, R Kimberly, JD Isaacs Nature Reviews Drug Discovery 6 (1), 75-92, 2007 | 338 | 2007 |
| Autologous tolerogenic dendritic cells for rheumatoid and inflammatory arthritis GM Bell, AE Anderson, J Diboll, R Reece, O Eltherington, RA Harry, ... Annals of the rheumatic diseases 76 (1), 227-234, 2017 | 310 | 2017 |
