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Rooma Desai
Rooma Desai
Verified email at mgh.harvard.edu
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Cited by
Year
GABAA receptor signalling mechanisms revealed by structural pharmacology
S Masiulis, R Desai, T Uchański, I Serna Martin, D Laverty, D Karia, ...
Nature 565 (7740), 454-459, 2019
4812019
Cryo-EM structure of the human α1β3γ2 GABAA receptor in a lipid bilayer
D Laverty, R Desai, T Uchański, S Masiulis, WJ Stec, T Malinauskas, ...
Nature 565 (7740), 516-520, 2019
2992019
Extracellular K+ and Opening of Voltage-Gated Potassium Channels Activate T Cell Integrin Function: Physical and Functional Association between Kv1.3 …
M Levite, L Cahalon, A Peretz, R Hershkoviz, A Sobko, A Ariel, R Desai, ...
The Journal of experimental medicine 191 (7), 1167-1176, 2000
2552000
Slack and Slick KNa channels regulate the accuracy of timing of auditory neurons
B Yang, R Desai, LK Kaczmarek
Journal of Neuroscience 27 (10), 2617-2627, 2007
1222007
Tryptophan mutations at azi-etomidate photo-incorporation sites on α1 or β2 subunits enhance GABAA receptor gating and reduce etomidate modulation
D Stewart, R Desai, Q Cheng, A Liu, SA Forman
Molecular Pharmacology 74 (6), 1687-1695, 2008
872008
Regulation of the timing of MNTB neurons by short-term and long-term modulation of potassium channels
LK Kaczmarek, A Bhattacharjee, R Desai, L Gan, P Song, CAA von Hehn, ...
Hearing research 206 (1-2), 133-145, 2005
732005
Ca2+-activated K+ channels in human leukemic Jurkat T cells: molecular cloning, biochemical and functional characterization
R Desai, A Peretz, H Idelson, P Lazarovici, B Attali
Journal of Biological Chemistry 275 (51), 39954-39963, 2000
712000
Kv3. 3 channels bind Hax-1 and Arp2/3 to assemble a stable local actin network that regulates channel gating
Y Zhang, XF Zhang, MR Fleming, A Amiri, L El-Hassar, AA Surguchev, ...
Cell 165 (2), 434-448, 2016
692016
γ-Amino butyric acid type A receptor mutations at β2N265 alter etomidate efficacy while preserving basal and agonist-dependent activity
R Desai, D Ruesch, SA Forman
The Journal of the American Society of Anesthesiologists 111 (4), 774-784, 2009
602009
Protein kinase C modulates inactivation of Kv3. 3 channels
R Desai, J Kronengold, J Mei, SA Forman, LK Kaczmarek
Journal of biological chemistry 283 (32), 22283-22294, 2008
522008
High‐level expression and purification of Cys‐loop ligand‐gated ion channels in a tetracycline‐inducible stable mammalian cell line: GABAA and serotonin receptors
Z Dostalova, A Liu, X Zhou, SL Farmer, ES Krenzel, E Arevalo, R Desai, ...
Protein Science 19 (9), 1728-1738, 2010
462010
Differential assembly diversifies GABAA receptor structures and signalling
A Sente, R Desai, K Naydenova, T Malinauskas, Y Jounaidi, J Miehling, ...
Nature 604 (7904), 190-194, 2022
442022
Requirement of Voltage-Gated Calcium Channel β4 Subunit for T Lymphocyte Functions
A Badou, S Basavappa, R Desai, YQ Peng, D Matza, WZ Mehal, ...
Science 307 (5706), 117-121, 2005
442005
Human α1β3γ2L gamma‐aminobutyric acid type A receptors: high‐level production and purification in a functional state
Z Dostalova, X Zhou, A Liu, X Zhang, Y Zhang, R Desai, SA Forman, ...
Protein Science 23 (2), 157-166, 2014
332014
Cysteine substitutions define etomidate binding and gating linkages in the α-M1 domain of γ-aminobutyric acid type A (GABAA) receptors
DS Stewart, M Hotta, G Li, R Desai, DC Chiara, RW Olsen, SA Forman
Journal of Biological Chemistry 288 (42), 30373-30386, 2013
332013
p-Trifluoromethyldiazirinyl-etomidate: A Potent Photoreactive General Anesthetic Derivative of Etomidate That Is Selective for Ligand-Gated Cationic Ion Channels
SS Husain, D Stewart, R Desai, AK Hamouda, SGD Li, E Kelly, ...
Journal of medicinal chemistry 53 (17), 6432-6444, 2010
302010
Positive and negative allosteric modulation of an α1β3γ2 γ-aminobutyric acid type A (GABAA) receptor by binding to a site in the transmembrane domain at the γ+-β− interface
SS Jayakar, X Zhou, PY Savechenkov, DC Chiara, R Desai, KS Bruzik, ...
Journal of Biological Chemistry 290 (38), 23432-23446, 2015
292015
Positive and negative allosteric modulation of an α1β3γ2 γ-aminobutyric acid type A (GABAA) receptor by binding to a site in the transmembrane domain at the γ+-β− interface
SS Jayakar, X Zhou, PY Savechenkov, DC Chiara, R Desai, KS Bruzik, ...
Journal of Biological Chemistry 290 (38), 23432-23446, 2015
292015
State-dependent etomidate occupancy of its allosteric agonist sites measured in a cysteine-substituted GABAA receptor
DS Stewart, M Hotta, R Desai, SA Forman
Molecular pharmacology 83 (6), 1200-1208, 2013
252013
Synthesis and pharmacological evaluation of neurosteroid photoaffinity ligands
PY Savechenkov, DC Chiara, R Desai, AT Stern, X Zhou, AM Ziemba, ...
European journal of medicinal chemistry 136, 334-347, 2017
162017
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