| Investigation of a Bicyclo[1.1.1]pentane as a Phenyl Replacement within an LpPLA2 Inhibitor ND Measom, KD Down, DJ Hirst, C Jamieson, ES Manas, VK Patel, ... ACS Medicinal Chemistry Letters 8 (1), 43-48, 2017 | 186 | 2017 |
| Recent advances in the synthetic chemistry of bicyclo [1.1. 1] pentane J Kanazawa, M Uchiyama Synlett 30 (01), 1-11, 2019 | 135 | 2019 |
| Optimization of novel indazoles as highly potent and selective inhibitors of phosphoinositide 3-kinase δ for the treatment of respiratory disease K Down, A Amour, IR Baldwin, AWJ Cooper, AM Deakin, LM Felton, ... Journal of medicinal chemistry 58 (18), 7381-7399, 2015 | 130 | 2015 |
| 4-carboxamide indazole derivatives useful as inhibitors of PI3-kinases IR Baldwin, KD Down, P Faulder, S Gaines, JN Hamblin, KL Jones, J Le, ... US Patent 8,163,743, 2012 | 58 | 2012 |
| Novel Compounds IR Baldwin, KD Down, P Faulder, S Gaines, JN Hamblin, J Le, CJ Lunniss, ... US Patent App. 12/994,253, 2011 | 40 | 2011 |
| Ozonolysis of some complex organic substrates in flow MD Roydhouse, WB Motherwell, A Constantinou, A Gavriilidis, R Wheeler, ... RSC advances 3 (15), 5076-5082, 2013 | 37 | 2013 |
| Discovery of 6-Aryl-7-alkoxyisoquinoline Inhibitors of IκB Kinase-β (IKK-β) JA Christopher, P Bamborough, C Alder, A Campbell, GJ Cutler, K Down, ... Journal of medicinal chemistry 52 (9), 3098-3102, 2009 | 37 | 2009 |
| Novel compounds IR Baldwin, KD Down, P Faulder, S Gaines, JN Hamblin, J Le, CJ Lunniss, ... US Patent App. 13/513,048, 2012 | 36 | 2012 |
| Optimization of orally bioavailable PI3Kδ inhibitors and identification of Vps34 as a key selectivity target ZA Henley, A Amour, N Barton, M Bantscheff, G Bergamini, SM Bertrand, ... Journal of Medicinal Chemistry 63 (2), 638-655, 2019 | 20 | 2019 |
| Benzpyrazole derivatives as inhibitors of pi3 kinases IR Baldwin, KD Down, P Faulder, S Gaines, JN Hamblin, KL Jones, ... US Patent App. 13/513,063, 2012 | 19 | 2012 |
| Novel Compounds IR Baldwin, KD Down, P Faulder, S Gaines, JN Hamblin, PS Jones, J Le, ... US Patent App. 12/994,254, 2011 | 18 | 2011 |
| The discovery and initial optimisation of pyrrole-2-carboxamides as inhibitors of p38α MAP kinase K Down, P Bamborough, C Alder, A Campbell, JA Christopher, M Gerelle, ... Bioorganic & medicinal chemistry letters 20 (13), 3936-3940, 2010 | 18 | 2010 |
| Discovery of potent, efficient, and selective inhibitors of phosphoinositide 3-kinase δ through a deconstruction and regrowth approach N Barton, M Convery, AWJ Cooper, K Down, JN Hamblin, G Inglis, ... Journal of Medicinal Chemistry 61 (24), 11061-11073, 2018 | 14 | 2018 |
| Indazole derivatives as pi 3-kinase IR Baldwin, KD Down, P Faulder, S Gaines, JN Hamblin, KL Jones, J Le, ... US Patent App. 13/513,079, 2012 | 14 | 2012 |
| Investigating the effects of the core nitrogen atom configuration on the thermodynamic solubility of 6, 5-bicyclic heterocycles B Cosgrove, K Down, S Bertrand, NCO Tomkinson, MD Barker Bioorganic & Medicinal Chemistry Letters 33, 127752, 2021 | 8 | 2021 |
| Discovery of GSK251: a highly potent, highly selective, orally bioavailable inhibitor of PI3Kδ with a novel binding mode K Down, A Amour, NA Anderson, N Barton, S Campos, EP Cannons, ... Journal of Medicinal Chemistry 64 (18), 13780-13792, 2021 | 3 | 2021 |
| Compounds IR Baldwin, KD Down, P Faulder, S Gaines, J Le, NJ Parr, TJ Ritchie, ... US Patent 8,536,169, 2013 | 2 | 2013 |
| Novel Use IR Baldwin, KD Down, P Faulder, S Gaines, JN Hamblin, ZA Harrison, ... US Patent App. 13/821,594, 2013 | 2 | 2013 |
| Compounds IR Baldwin, KD Down, P Faulder, S Gaines, JN Hamblin, J Le, CJ Lunniss, ... US Patent 8,765,743, 2014 | 1 | 2014 |
| Substituted pyrazolo [1, 5-a] pyrimidines as PI4K inhibitors NP Barton, SM Bertrand, KD Down, M Gray US Patent 11,649,238, 2023 | | 2023 |
