Ian Slaymaker
Ian Slaymaker
Broad Institute
Verified email at broadinstitute.org
Title
Cited by
Cited by
Year
Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system
B Zetsche, JS Gootenberg, OO Abudayyeh, IM Slaymaker, KS Makarova, ...
Cell 163 (3), 759-771, 2015
27922015
Rationally engineered Cas9 nucleases with improved specificity
IM Slaymaker, L Gao, B Zetsche, DA Scott, WX Yan, F Zhang
Science 351 (6268), 84-88, 2016
17822016
C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector
OO Abudayyeh, JS Gootenberg, S Konermann, J Joung, IM Slaymaker, ...
Science 353 (6299), 2016
11042016
Crystal structure of Cpf1 in complex with guide RNA and target DNA
T Yamano, H Nishimasu, B Zetsche, H Hirano, IM Slaymaker, Y Li, ...
Cell 165 (4), 949-962, 2016
4302016
Cas13b is a type VI-B CRISPR-associated RNA-guided RNase differentially regulated by accessory proteins Csx27 and Csx28
AA Smargon, DBT Cox, NK Pyzocha, K Zheng, IM Slaymaker, ...
Molecular cell 65 (4), 618-630. e7, 2017
3302017
CRISPR enzymes and systems
F Zhang, B Zetsche, I Slaymaker, J Gootenberg, OO Abudayyeh
US Patent 9,790,490, 2017
1932017
Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits
RJ Platt, Y Zhou, IM Slaymaker, AS Shetty, NR Weisbach, JA Kim, ...
Cell reports 19 (2), 335-350, 2017
1232017
Directed evolution of adenine base editors with increased activity and therapeutic application
NM Gaudelli, DK Lam, HA Rees, NM Solá-Esteves, LA Barrera, DA Born, ...
Nature biotechnology 38 (7), 892-900, 2020
892020
High-resolution structure of Cas13b and biochemical characterization of RNA targeting and cleavage
IM Slaymaker, P Mesa, MJ Kellner, S Kannan, E Brignole, J Koob, ...
Cell reports 26 (13), 3741-3751. e5, 2019
342019
MCM structure and mechanics: what we have learned from archaeal MCM
IM Slaymaker, XS Chen
The Eukaryotic Replisome: a Guide to Protein Structure and Function, 89-111, 2012
302012
Base editing: advances and therapeutic opportunities
EM Porto, AC Komor, IM Slaymaker, GW Yeo
Nature Reviews Drug Discovery 19 (12), 839-859, 2020
272020
Mini-chromosome maintenance complexes form a filament to remodel DNA structure and topology
IM Slaymaker, Y Fu, DB Toso, N Ranatunga, A Brewster, SL Forsburg, ...
Nucleic acids research 41 (5), 3446-3456, 2013
262013
Mutational analysis of an archaeal minichromosome maintenance protein exterior hairpin reveals critical residues for helicase activity and DNA binding
AS Brewster, IM Slaymaker, SA Afif, XS Chen
BMC molecular biology 11 (1), 1-8, 2010
222010
CRISPR enzyme mutations reducing off-target effects
F Zhang, L Gao, B Zetsche, I Slaymaker
US Patent 10,876,100, 2020
142020
The 1.8-Ĺ crystal structure of the N-terminal domain of an archaeal MCM as a right-handed filament
Y Fu, IM Slaymaker, J Wang, G Wang, XS Chen
Journal of molecular biology 426 (7), 1512-1523, 2014
132014
Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein fatty acid amide hydrolase
IM Slaymaker, M Bracey, M Mileni, J Garfunkle, BF Cravatt, DL Boger, ...
Bioorganic & medicinal chemistry letters 18 (22), 5847-5850, 2008
122008
CRISPR enzymes and systems
F Zhang, B Zetsche, I Slaymaker, J Gootenberg, OO Abudayyeh
US Patent 10,669,540, 2020
102020
CRISPR–Cas9 mediated DNA unwinding detected using site-directed spin labeling
NS Tangprasertchai, R Di Felice, X Zhang, IM Slaymaker, ...
ACS chemical biology 12 (6), 1489-1493, 2017
102017
Rationally designed base editors for precise editing of the sickle cell disease mutation
SH Chu, M Packer, H Rees, D Lam, Y Yu, J Marshall, LI Cheng, D Lam, ...
The CRISPR Journal 4 (2), 169-177, 2021
82021
Novel crispr enzymes and systems
F Zhang, B Zetsche, JS Gootenberg, OO Abudayyeh, I Slaymaker
US Patent App. 16/400,026, 2019
52019
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