Louise J. Barber
Louise J. Barber
Research Scientist, Institute of Cancer Research
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RTEL1 maintains genomic stability by suppressing homologous recombination
LJ Barber, JL Youds, JD Ward, MJ McIlwraith, NJ O'Neil, MIR Petalcorin, ...
Cell 135 (2), 261-271, 2008
Secondary mutations in BRCA2 associated with clinical resistance to a PARP inhibitor
LJ Barber, S Sandhu, L Chen, J Campbell, I Kozarewa, K Fenwick, ...
The Journal of pathology 229 (3), 422-429, 2013
A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination
GY Zhao, E Sonoda, LJ Barber, H Oka, Y Murakawa, K Yamada, T Ikura, ...
Molecular cell 25 (5), 663-675, 2007
FANCJ is a structure-specific DNA helicase associated with the maintenance of genomic G/C tracts
TBC London, LJ Barber, G Mosedale, GP Kelly, S Balasubramanian, ...
Journal of biological chemistry 283 (52), 36132-36139, 2008
Cancer evolution and the limits of predictability in precision cancer medicine
KA Lipinski, LJ Barber, MN Davies, M Ashenden, A Sottoriva, M Gerlinger
Trends in cancer 2 (1), 49-63, 2016
Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2
SA Martin, A McCarthy, LJ Barber, DJ Burgess, S Parry, CJ Lord, ...
EMBO molecular medicine 1 (6‐7), 323-337, 2009
Efficacy of chemotherapy in BRCA1/2 mutation carrier ovarian cancer in the setting of PARP inhibitor resistance: a multi-institutional study
JE Ang, C Gourley, CB Powell, H High, R Shapira-Frommer, ...
Clinical Cancer Research 19 (19), 5485-5493, 2013
HCLK2 is essential for the mammalian S-phase checkpoint and impacts on Chk1 stability
SJ Collis, LJ Barber, AJ Clark, JS Martin, JD Ward, SJ Boulton
Nature cell biology 9 (4), 391, 2007
Genomic and transcriptomic determinants of therapy resistance and immune landscape evolution during anti-EGFR treatment in colorectal cancer
A Woolston, K Khan, G Spain, LJ Barber, B Griffiths, R Gonzalez-Exposito, ...
Cancer cell 36 (1), 35-50. e9, 2019
Inhibitors of the proteasome suppress homologous DNA recombination in mammalian cells
Y Murakawa, E Sonoda, LJ Barber, W Zeng, K Yokomori, H Kimura, ...
Cancer research 67 (18), 8536-8543, 2007
DOG-1 is the Caenorhabditis elegans BRIP1/FANCJ homologue and functions in interstrand cross-link repair
JL Youds, LJ Barber, JD Ward, SJ Collis, NJ O'Neil, SJ Boulton, AM Rose
Molecular and cellular biology 28 (5), 1470-1479, 2008
Replication blocking lesions present a unique substrate for homologous recombination
JD Ward, LJ Barber, MIR Petalcorin, J Yanowitz, SJ Boulton
The EMBO journal 26 (14), 3384-3396, 2007
Poly (ADP-ribose) polymerase (PARP) inhibitors for the treatment of advanced germline BRCA2 mutant prostate cancer
SK Sandhu, A Omlin, L Hylands, S Miranda, LJ Barber, R Riisnaes, ...
Annals of oncology 24 (5), 1416-1418, 2013
DNA interstrand cross-link repair in the Saccharomyces cerevisiae cell cycle: overlapping roles for PSO2 (SNM1) with MutS factors and EXO1 during S phase
LJ Barber, TA Ward, JA Hartley, PJ McHugh
Molecular and cellular biology 25 (6), 2297-2309, 2005
C. elegans FANCD2 responds to replication stress and functions in interstrand cross-link repair
SJ Collis, LJ Barber, JD Ward, JS Martin, SJ Boulton
DNA repair 5 (11), 1398-1406, 2006
Human SNM1A suppresses the DNA repair defects of yeast pso2 mutants
A Hazrati, M Ramis-Castelltort, S Sarkar, LJ Barber, CJ Schofield, ...
DNA repair 7 (2), 230-238, 2008
Dissecting cancer evolution at the macro-heterogeneity and micro-heterogeneity scale
LJ Barber, MN Davies, M Gerlinger
Current opinion in genetics & development 30, 1-6, 2015
CEA expression heterogeneity and plasticity confer resistance to the CEA-targeting bispecific immunotherapy antibody cibisatamab (CEA-TCB) in patient-derived colorectal cancer …
R Gonzalez-Exposito, M Semiannikova, B Griffiths, K Khan, LJ Barber, ...
Journal for immunotherapy of cancer 7 (1), 101, 2019
The MRT‐1 nuclease is required for DNA crosslink repair and telomerase activity in vivo in Caenorhabditis elegans
B Meier, LJ Barber, Y Liu, L Shtessel, SJ Boulton, A Gartner, S Ahmed
The EMBO journal 28 (22), 3549-3563, 2009
Schizosaccharomyces pombe checkpoint response to DNA interstrand cross-links
S Lambert, SJ Mason, LJ Barber, JA Hartley, JA Pearce, AM Carr, ...
Molecular and cellular biology 23 (13), 4728-4737, 2003
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